This chapter brings the book to a close by reflecting the complexity of contemporary local–global relations, focusing on questions of positive relationality, sustainability, productivity, and vitality. It responds to the compounding crisis of our time, a manifold crisis which encompasses processes of ecological, economic, political, and cultural unsettling. The argument presented here is that a manifesto for positive local–global relations needs to confront the contemporary human condition in all its interconnected crises and wonders. It needs to be able to project into the future as well as provide guidance for present activities. And it needs to remain a heuristic and negotiable framework for continuing dialogue over principles rather be fixed as a set of edicts or targets. Rather than providing a blueprint for change, the chapter presents manifesto making as a method. Nevertheless, it presents a series of fundamental principles that are suggestive for rethinking the present human condition.