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4 - Healthy research: study designs for public health

Penny Webb  and
Chris Bain
Penny Webb
Affiliation:
Queensland Institute of Medical Research
Chris Bain
Affiliation:
University of Queensland
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Summary

Box 4.1 Oranges and lemons

In 1747, James Lind conducted an experiment to test six different cures for scurvy. While at sea, he identified 12 patients with scurvy whose ‘cases were as similar as I could find them’ and prescribed a different treatment to each pair of patients. After a few days he found that the two patients fortunate enough to have been prescribed oranges and lemons were almost fully recovered whilst no improvement was seen in the other ten, who had been subjected to various regimens including sea-water, gruel, cider and various elixirs. From this, Lind inferred that inclusion of citrus fruit in the diet of sailors would not only cure, but also prevent scurvy. Limes or lime juice thus became a part of the diet on ships, earning British sailors their nickname of ‘limeys’

(Lind, 1753).

When we discussed what epidemiologists do in Chapter 1, we touched on some of the different types of study that we use to collect the information we need to answer questions about health. In Chapter 3 we looked at the descriptive studies that provide the ‘bread-and-butter’ information of public health; in this chapter we will look at the analytic studies that are our main tools for identifying the causes of disease and evaluating health interventions. Unlike descriptive epidemiology, analytic studies involve planned comparisons between people with and without disease, or between people with and without exposures thought to cause disease.

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Essential Epidemiology
An Introduction for Students and Health Professionals
 , pp. 94 - 124
Publisher: Cambridge University Press
Print publication year: 2010

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References

,45 and Up Study Collaborators. (2008). Cohort profile: the 45 and Up Study. International Journal of Epidemiology, 37: 941–947.Google Scholar
Ast, D. B. and Schlesinger, E. R. (1956). The conclusion of a ten-year study of water fluoridation. American Journal of Public Health, 46: 265–271.Google Scholar
Beaglehole, R., Bonita, R. and Kjellström, T. (1993). Basic Epidemiology. Geneva: World Health Organization.
Beecher, H. K. (1966). Ethics and clinical research. New England Journal of Medicine, 274: 1354–1360.Google Scholar
Coogan, P. F., Rosenberg, L. and Strom, B. L. (2007). Statin use and the risk of 10 cancers. Epidemiology, 18: 213–219.Google Scholar
Dawber, T. R. (1980). The Framingham Study. The Epidemiology of Atherosclerotic Disease. Harvard: Harvard University Press.CrossRef
Doll, R. and Hill, A. B. (1964). Mortality in relation to smoking: ten years' observations of British doctors. British Medical Journal, 1: 1399–1410, 1460–1467.Google Scholar
Francis, Jr T., Korns, R. F., Voight, R. B. et al. (1955). An evaluation of the 1954 poliomyelitis vaccine trials: summary report. American Journal of Public Health, 45: 1–65.Google Scholar
Frankel, S., Gunnell, D. J., Peters, T. J., Maynard, M. and Davey, Smith G. (1998). Childhood energy intake and adult mortality from cancer: the Boyd Orr cohort study. British Medical Journal, 316: 499–504.Google Scholar
Golding, J., Pembrey, M., Jones, R. and the ALSPAC Study Team. (2001). ALSPAC – the Avon Longitudinal Study of Parents and Children. I. Study methodology. Paediatric and Perinatal Epidemiology, 15: 74–87.Google Scholar
Hennekens, C. H. and Eberlein, K. (1985). A randomised trial of aspirin and b-carotene among U.S. physicians. Preventive Medicine, 14: 165–168.Google Scholar
,ISIS-2 Collaborative Group. (1988). Randomised trial of intravenous streptokinase, oral aspirin, both or neither among 17187 cases of suspected acute myocardial infarction: ISIS-2. Lancet, 2: 349–360.Google Scholar
Jordan, S. J., Green, A. C., Whiteman, D. C. et al. (2008). Serous ovarian, fallopian tube and primary peritoneal cancers: a comparative epidemiological analysis. International Journal of Cancer, 122: 1598–1603.Google Scholar
Kelman, C. W., Bass, A. J. and Holman, C. D. J. (2002). Research use of linked data – a best practice protocol. Australian and New Zealand Journal of Public Health, 26: 251–255.Google Scholar
Lawlor, D. A. and Stone, T. (2001). Public health and data protection: an inevitable collision or potential for a meeting of minds? International Journal of Epidemiology, 30: 1221–1225.Google Scholar
Lind, J. (1753). A Treatise of the Scurvy. A Bicentenary Volume. Edinburgh: Sands, Murray and Cochran.
Maclure, M. (1991). The case–crossover design: a method for studying transient effects on the risk of acute events. American Journal of Epidemiology, 133: 144–153.Google Scholar
Mellin, G. W. and Katzenstein, M. (1962). The saga of thalidomide: neuropathy to embryopathy, with case reports of congenital anomalies. New England Journal of Medicine, 267: 1184–1193, 1238–1244.Google Scholar
Nagle, C. M., Purdie, D. M., Webb, P. M. et al. (2003). Dietary influences on survival following ovarian cancer. International Journal of Cancer, 106: 264–269.Google Scholar
PaffenbargerJr, R. S., Hyde, R. T., Wing, A. L. and Hsieh, C. C. (1986). Physical activity, all-cause mortality, and longevity of college alumni. New England Journal of Medicine, 314: 605–613.Google Scholar
Pillai, A., Andrews, T. and Patel, V. (2009). Violence, psychological distress and the risk of suicidal behaviour in young people in India. International Journal of Epidemiology, 38: 459–469.Google Scholar
Ponsonby, A. L., Dwyer, T., Gibbons, L. E., Cochrane, J. A. and Wang, Y-G. (1993). Factors potentiating the risk of sudden death syndrome associated with the prone position. New England Journal of Medicine, 329: 377–382.Google Scholar
Rockhill, B., Willett, W. C., Hunter, D. J. et al. (1998). Physical activity and breast cancer risk in a cohort of young women. Journal of the National Cancer Institute, 90: 1155–1160.Google Scholar
Sandler, D. P., Smith, J. C., Weinberg, C. R. et al. (1989). Analgesic use and chronic renal disease. New England Journal of Medicine, 320: 1238–1243.Google Scholar
Sommer, A., Tarwotjo, I., Djunaedi, E. et al. (1986). Impact of vitamin A supplementation on childhood mortality. A randomised controlled community trial. The Lancet, 327: 1169–1173.Google Scholar
Stampfer, M. J., Willett, W. C., Colditz, G. A., Speizer, F. E. and Hennekens, C. H. (1988). A prospective study of past use of oral contraceptive agents and risk of cardiovascular diseases. New England Journal of Medicine, 319: 1313–1317.Google Scholar
,The EUROGAST Study Group. (1993). An international association between Helicobacter pylori infection and gastric cancer. Lancet, 341: 1359–1362.Google Scholar
,The Million Women Study Collaborative Group. (1999). The Million Women Study: design and characteristics of the study population. Breast Cancer Research, 1: 73–80.Google Scholar
Zendehdel, K., Nyrén, O., Östenson, C.-G. et al. (2003). Cancer incidence in patients with type 1 diabetes: a population-based cohort study in Sweden. Journal of the National Cancer Institute, 95: 1797–1800.Google Scholar
Zhang, M., Holman, C. D. J., Price, S. D. et al. (2009). Comorbidity and repeat admission to hospital for adverse drug reactions in older adults: retrospective cohort study. British Medical Journal, 338: a2752 doi: 10.1136/bmj.a2752.Google Scholar

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