In the first years of the twenty-first century, Presidents Vladimir Putin and George W. Bush sought to develop a strategic and economic partnership. Yet by 2007 US–Russian relations were marked by friction, and after 2012 they deteriorated into bitter enmity. This chapter argues that blaming the degeneration of relations on the KGB background, paranoia, and imperial ambitions of Putin is too simple and one-sided. It shows that the United States also spurred the decline by supporting “color revolutions” in countries around Russia, promoting NATO membership for Georgia and Ukraine, pushing regime change in countries such as Syria, Libya, and Venezuela, and placing missile defense systems in Eastern Europe. Although Russia and the United States cooperated on a strategic arms reduction treaty, Russian entry into the World Trade Organization, and restrictions on Iran’s nuclear program, conflict increasingly overshadowed such collaboration. That outcome was not inevitable. Instead, unwise policy choices led to clashes, dishonest statements eroded trust, needlessly provocative rhetoric exacerbated tensions, and media sensationalism inflamed antipathies between Americans and Russians.