Queer and trans of color critique engages the ways sexuality and gender themselves gain meaning in the context of systems of racial differentiation and, reciprocally, how struggles for justice, abolition, freedom, and decolonization must attend to sexuality and gender as both vectors of domination and sites of liberatory imagination and expression. This chapter considers how attributions of savagery, criminality, and inassimilable alienness to racialized populations in the United States are shaped by narratives of these groups’ inability to enact proper gender and sexuality. The chapter further considers how queer and trans of color critique addresses the specificities in how particular racialized groups are defined through systems of sexual and gender normativity and how they have engaged those systems in multidimensional ways, attending to queer and trans work in Black studies, Latinx studies, Asian American studies, and Indigenous studies. It traces differences and disagreements within those fields and tracks dialogues among/across them.