Evidence-based psychotherapeutic approaches for personality disorders are in general lengthy and intensive and rely heavily on access to extensively trained and highly skilled therapists. Since these are resource requirements that can often not be met by treatment providers in the average routine clinical setting, many attempts have been made to develop brief interventions or abbreviated versions of existing approaches to the treatment of personality disorders. Despite these attempts, knowledge is still limited.This commentary discusses some of the knowledge that is lacking and questions and challenges that seem to remain for the task of developing and validating brief interventions for personality disorders.