The Default Mode Network and Language Impairment in Stroke and Neurodegeneration

doi:10.1017/9781009202336.010

7 - The Default Mode Network and Language Impairment in Stroke and Neurodegeneration

from Part III - Language and Cognitive Plasticity and Processing

Published online by Cambridge University Press: 12 December 2025

E. Susan Duncan ,

Aswathy Anakkathil Pradeep ,

Juhi Kidwai and

Adam Buchwald

Edited by

Edna Andrews and

Swathi Kiran

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Edna Andrews: Affiliation:
Duke University, North Carolina
Swathi Kiran: Affiliation:
Boston University

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Summary

This chapter discusses the default mode network (DMN), a set of anatomically distinct and functionally correlated brain regions robustly active during the resting state. Once considered the “task negative” network, the DMN is now appreciated as integral to a variety of higher-level, goal-directed skills that are bidirectionally linked to language. Such abilities are dependent on optimal interaction of the DMN with other brain networks. We first review the DMN’s association with cognition and language in the healthy brain, as well as how these change with aging, stroke, and neurodegeneration. Next, we survey existing research describing changes in DMN activation and functional connectivity in post-stroke and primary progressive aphasia as they relate to language impairment. While this connection remains poorly elaborated, we propose that current evidence supports a potential therapeutic role for the DMN, such as through offering targets for noninvasive brain stimulation that support domain-general skills and are also better structurally preserved in post-stroke and primary progressive aphasias compared to the language regions primarily impacted by these disorders. Greater understanding of the DMN’s role in language disruption, decline, maintenance, and recovery could ultimately help to improve outcomes for individuals with aphasia due to stroke or neurodegeneration.

Keywords

default mode network language network stroke neurodegeneration functional connectivity resting state noninvasive brain stimulation

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Type: Chapter
Information: The Cambridge Handbook of Language and Brain , pp. 147 - 170

DOI: https://doi.org/10.1017/9781009202336.010 [Opens in a new window]

Publisher: Cambridge University Press

Print publication year: 2025

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