During wartime, the Constitution requires the president to lead the nation as commander-in-chief. But what about first ladies? As wives, mothers, and co-equal partners, these “first ladies-in-chief” have found themselves serving as field companion to the commander-in-chief, mother-in-chief to sons on combat duty, steward of national resources, and caretakers to the nation’s wounded. This chapter considers six prominent first ladies during major American conflicts: Martha Washington and the Revolutionary War, Dolley Madison and the War of 1812, Mary Todd Lincoln and the Civil War, Edith Wilson and World War I, Eleanor Roosevelt and World War II, Lady Bird Johnson and Vietnam, and Barbara and Laura Bush during the first and second Gulf Wars. Taken together, they paint the first lady as a vital contributor to the nation’s military efforts who deserve our recognition and respect.