Primary Progressive Aphasia

doi:10.1017/9781108985055.012

Chapter 12 - Primary Progressive Aphasia

from Section 2 - The Dementias

Published online by Cambridge University Press: aN Invalid Date NaN

Zachary A. Miller ,

Gaia C. Santi and

Maria Luisa Gorno-Tempini

Edited by

Bruce L. Miller and

Bradley F. Boeve

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Bruce L. Miller: Affiliation:
University of California, San Francisco
Bradley F. Boeve: Affiliation:
Mayo Clinic, Minnesota

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Summary

Primary progressive aphasia (PPA) is a neurodegenerative disorder that primarily affects language abilities. There are three main variants of PPA: semantic variant PPA (svPPA), nonfluent variant PPA (nfvPPA), and logopenic variant PPA (lvPPA). Each variant has distinct clinical features, neuroimaging findings, and genetic and pathological associations. However, some cases do not fit neatly into these categories, known as PPA not otherwise specified. Diagnosis of PPA requires a comprehensive evaluation of language and cognitive abilities, along with neuroimaging and biomarker data. Future directions in PPA research include the development of computerized algorithms for speech analysis, the exploration of non-verbal aspects of the disorder, and the investigation of potential therapeutic interventions.

Keywords

primary progressive aphasia semantic variant nonfluent variant logopenic variant language impairment neurodegenerative disorders speech and language deficits diagnostic criteria neuroimaging findings genetic and pathological findings

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Type: Chapter
Information: The Behavioral Neurology of Dementia , pp. 180 - 198

DOI: https://doi.org/10.1017/9781108985055.012 [Opens in a new window]

Publisher: Cambridge University Press

Print publication year: 2025

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