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from Section III - The Best Policy
Published online by Cambridge University Press: 25 November 2021
Uterine fibroids may cause infertility, depending on their size and their location [1]. The mechanisms linking uterine fibroids and infertility are numerous: uterine cavity distortion according to the FIGO classification; impaired endometrial and myometrial blood supply; increased uterine contractility; hormonal, paracrine and molecular changes; impaired endometrial receptivity and gene expression (decrease in homeobox 10 [HOXA-10] expression); and thicker capsule. The effect on infertility of fibroids distorting the cavity is easy to understand. We will also review the influence of non-cavity-distorting intramural fibroids.
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