Intralipid infusion is seen as a popular supplemental option to treat implantation failure or recurrent miscarriage. It is a good example of how hype preceded scientific validation. Intralipid is a fat emulsion that is essentially used as parenteral nutrition. Following the observation that the infusion of Intralipid may modulate the expression of NK cells, its use began in the treatment of implantation failure in IVF treatment. Its adoption into clinical practice was not dissimilar to many other unproven treatments that become popular because they are available and considered to be low risk. However, Intralipid seems to have escaped any rigorous randomised controlled trial (RCT). Despite a demonstrable lack of efficacy in observational data, and two low-powered RCTs, it continues to be used in practice. In the interest of maintaining scientific credibility, the use of Intralipid should be restricted only in the realms of research.