This study presents three key steps to enable the Business and Human Rights (BHR) research agenda to promote and advance greater applicability to the emerging challenges in the field. Drawing on research conducted on BHR sources (almost exclusively by Brazilian and Spanish-speaking authors), this article aims to demonstrate the need for further BHR scholarship to simultaneously: (i) identify and remedy epistemic biases through reflexive engagement with a victim-centred scholarship from the Global South that recentres BHR research on the perspective of affected communities; (ii) move from consideration to co-production by grounding BHR theory in practice via participatory methodologies and dialogue between communities, researchers and corporations; and (iii) by aligning with steps one and two, recontextualize Human Rights Due Diligence (HRDD) research into an integrated Human Rights and Environmental Due Diligence (HREDD) approach that incorporates environmental and climate dimensions and ensure meaningful, victim-centred engagement with affected communities.