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2 results

  • Effects of whole-body vibration on motor function in patients with Parkinson’s disease: a systematic review and meta-analysis

  • Chuan He, Caixia Su, Wentong Zhang, Qi Wan
  • Journal:
    Brain Impairment / Volume 22 / Issue 2 / September 2021
    Published online by Cambridge University Press:
    04 December 2020, pp. 205-216
  • Objective:

    To review the effects of whole body vibration for patients with Parkinson’s disease.

    Design:

    Randomized clinical trials comparing whole body vibration with no vibration or conventional physical therapy for patients with Parkinson’s disease were searched up to July 31, 2019.

    Results:

    Seven studies with 196 patients were included for quantitative analysis. No significant difference was found between groups in motor score of unified Parkinson’s disease rating scale (UPDRS-III) (WMD [weighted mean difference] = −1.75, 95% CI, −5.40 to 1.90, I2 = 45.8%), functional reach test (SMD [standardized mean difference] = 0.21, 95% CI, −0.29 to 0.71; I2 = 0%), and other balance tests (including Berg balance test and Tinetti score) (SMD = 0.39, 95% CI, −0.01 to 0.80; I2 = 0%). No statistical difference was detected in walking velocity as well (WMD = −0.05, 95% CI, −0.17 to 0.06; I2 = 0%). In contrast, the pooled analysis from four studies on the Time Up and Go test showed favorable results for whole body vibration (WMD = −1.59, 95% CI, −2.90 to −0.28, I2 = 0%).

    Conclusion:

    Whole body vibration may not be beneficial over placebo or conventional physical therapy in overall motor function, balance, and walking velocity in patients with Parkinson’s disease. However, it might have positive effects on sit to stand transitions or turning.

  • Chapter 35 - Teriflunomide to treat multiple sclerosis

  • from Section III - Clinical trials of multiple sclerosis therapies
  • Edited by Jeffrey A. Cohen, Richard A. Rudick
  • Book:
    Multiple Sclerosis Therapeutics
    Published online:
    05 December 2011
    Print publication:
    20 October 2011, pp 410-417

  • Summary

    Glatiramer acetate (GA) seems to affect immune cells in an antigenic specific way, and could be considered as an example of a therapeutic vaccination, as opposed to the prophylactic vaccinations commonly used for infectious diseases. The first human use of GA was in three patients with acute disseminated encephalomyelitis and four in the terminal stages of multiple sclerosis (MS). Cross-sectional analysis of data from the extended, open label follow-up of the US trial investigated the consequences of long-term GA treatment on several magnetic resonance imaging (MRI) markers of MS activity and disease burden. As GA has unique mechanisms of action, which differs from those of other MS disease therapies, use in combination with other agents might produce additive or synergistic therapeutic effects and better efficacy. The effects of oral GA were extensively studied in both rodents and primates in acute and chronic relapsing experimental autoimmune encephalomyelitis (EAE) models.