Let N be a closed s-Hopfian n-manifold with residually finite, torsion free π1 (N) and finite H1(N). Suppose that either πk(N) is finitely generated for all k ≥ 2, or πk(N) ≅ 0 for 1 < k < n – 1, or n ≤ 4. We show that if N fails to be a co-dimension 2 fibrator, then N cyclically covers itself, up to homotopy type.