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33 - Monitoring of pharmaceutical interventions: MR plaque imaging
from Monitoring pharmaceutical interventions
- By Thomas Hatsukami, University of Washington, Seattle WA, USA
Edited by Jonathan Gillard, University of Cambridge, Martin Graves, University of Cambridge, Thomas Hatsukami, University of Washington, Chun Yuan, University of Washington
Book:

Carotid Disease

Published online:

03 December 2009

Print publication:

07 December 2006, pp 464-470
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Summary

Magnetic resonance imaging (MRI) detects significant changes in the morphology of atherosclerotic plaque during the course of lipid-lowering therapy, and demonstrates the promise of this noninvasive imaging modality for use in clinical trials. Images obtained from the placebo-control arm of a five-site carotid MRI study were analyzed to assess the variability of MRI for measuring lesion size and composition, and to provide sample size calculations for a variety of imaging endpoints. MRI is capable of quantifying atherosclerotic lesion size and plaque composition in the setting of a multicenter trial with low interscan variability. Sample-size calculations based on reproducibility data for carotid MRI indicate that clinical trials involving approximately 150 subjects per treatment arm would be sufficiently powered to detect a 5% difference in treatment effect. MRI may provide valuable insight into pathophysiology and mechanisms of pharmacologic activity.

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33 - Monitoring of pharmaceutical interventions: MR plaque imaging

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33 - Monitoring of pharmaceutical interventions: MR plaque imaging

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