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2 results

  • 34 - The Role of Sleep in Cognitive Aging

  • from Part V - Later Life and Interventions
  • Edited by Ayanna K. Thomas, Tufts University, Massachusetts, Angela Gutchess, Brandeis University, Massachusetts
  • Book:
    The Cambridge Handbook of Cognitive Aging
    Published online:
    28 May 2020
    Print publication:
    28 May 2020, pp 628-644

  • Summary

    Aging is marked by cognitive decline, which in the case of Alzheimer’s disease is associated with tremendous global economic burden. Identifying modifiable risk factors for cognitive decline is therefore of paramount importance. In this chapter, we describe how aging compromises sleep quality and sleep architecture at a rate that parallels normal age-related cognitive decline. We argue that understanding the neurocognitive functions of sleep – frontal lobe restoration, memory consolidation, and metabolite clearance – and how such functions change in later life will be key to informing why some older individuals maintain healthy cognitive functioning and other older individuals do not. Critically, by investigating how sleep, cognition, and aging interact, researchers and clinicians can develop sleep-related treatments that target preventing, or at least ameliorating, pathologies such as Alzheimer’s disease.

  • Chapter 51 - Functional neuroimaging: sedating medication effects

  • from Section 5 - Neuroimaging of sleep disorders
  • Edited by Eric Nofzinger, University of Pittsburgh, Pierre Maquet, Université de Liège, Belgium, Michael J. Thorpy
  • Book:
    Neuroimaging of Sleep and Sleep Disorders
    Published online:
    05 March 2013
    Print publication:
    07 March 2013, pp 396-405

  • Summary

    This chapter focuses on primary sleep disorders in Parkinson's disease (PD) and multiple system atrophy (MSA) and insights provided by functional neuroimaging research. Specific disorders to be considered include excessive daytime sleepiness (EDS), sleep disordered breathing, restless legs syndrome/periodic limb movements in sleep (RLS/PLMS), and rapid eye movement (REM) sleep behavior disorder (RBD). The chapter reviews the relevant neurochemical pathways in PD and MSA, and discusses specific sleep disorders. It explains the neurotransmitter in more detail, as it relates to PD, MSA, and sleep circuits. The neurotransmitter dopamine may play a role in REM sleep control, but there is limited direct evidence for this. Dopamine may also play a role in regulation of the sleep/wake cycle with a wakefulness promoting effect that is similar to histamine and hypocretin. In the future, a greater focus should be placed on non-dopaminergic pathways to evaluate sleep disorders in PD and MSA.