This article examines a case of phonological opacity in Uyghur resulting from an interaction between backness harmony and a vowel reduction process that converts harmonic vowels into transparent vowels. A large-scale corpus study shows that although opaque harmony with the underlying form of a reduced vowel is the dominant pattern, cases of surface-apparent harmony also occur. The rate of surface-apparent harmony varies across roots and is correlated with a number of factors, including root frequency. These data pose problems for standard accounts of opacity, which do not predict such variation. I propose an analysis where variation emerges from conflict between a paradigm uniformity constraint mandating that the harmonising behaviour of a root remains consistent, and surface phonotactic constraints. This is implemented in a parallel model by scaling constraint violations according to certainty in a root’s harmonic class. This aligns with past work suggesting some opacity is driven by paradigm uniformity.