This ethnographic study reassesses the role of opium in Iran’s economic landscape, challenging dominant narratives that frame opium users as unproductive and burdensome. Based on fieldwork conducted between 2010 and 2018 in the Pars Special Economic Energy Zone (PSEEZ), the research examines how construction workers use opium to endure and enhance productivity under extreme environmental and economic pressures. It critiques a century-long anti-opium discourse—rooted in the Iranian Constitutional Movement (1905–1911) and perpetuated through shifting regimes of criminalization and medicalization—that consistently associates opium use with economic idleness. Through autoethnographic reflection and archival analysis, the article first outlines this dominant discourse, then constructs a counternarrative in which laborers deliberately integrate opium into their daily practices to sustain bodily performance and contribute to Iran’s petroindustrial expansion. Described as “narco-nomad science,” this practice enables the formation of resilient working bodies and repositions opium as an active agent within circuits of capitalist production. Drawing on actor-network theory and assemblage thinking, the study foregrounds the material agency of opium. It offers new analytical frameworks for understanding its role in labor, infrastructure, and the political economy of the PSEEZ.