The purpose of this essay is to explore Adam Smith’s work for ideas relevant to modern-day discourse on pluralism (understood as methodological pluralism). It is argued here that the emphasis on difference of perspective in his theory of human nature is potentially foundational for pluralism. I explore Smith’s philosophy of science, where his theory of human nature explains the motivation for building knowledge, the conduct of enquiry, and the appraisal of resulting theories. Finally, I explore exemplars of pluralist practice in Smith’s treatment of alternative approaches to economics to his own as well as in his account of different approaches to history and astronomy.