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The manner of expression of human malaise has changed and evolved a lot over time. With regard to the specific relationship with the body, we can also observe that it has evolved over time in response to some contradictory hypermodern drives. It is therefore appropriate to investigate how people sometimes feel drawn into a social climate that is full of confusing and contradictory messages and dynamics that are often difficult to elaborate, and what the effects of this context are. Human symbolization and mentalization processes therefore seem rooted in the body and relationships, which in turn are rooted in a specific social context that is changing, adding further complexity and transforming the concept of the human body in turn.
Percy’s classic novel grapples self-consciously with the complexities of its relation to a sense of place and its setting in mid-twentieth-century New Orleans. Percy himself was ambivalent about New Orleans, just as the protagonist of his novel is, and chose to live on the north shore of Lake Pontchartrain to avoid the distractions of the city, and his deliberate dislocation vis-à-vis the famous city undergirds his deeply philosophic inquiry into the meaning of place, an inquiry tha, for the main character in the novel is tied to the posttraumatic stress disorder that followed his wounding in the Korean War.
The centrality of decadence to the development of modernism is clear in the work of the major modernist figures James Joyce, Marcel Proust, and Thomas Mann. Joyce expatiates on decadent traits with such encyclopaedic abandon in the ‘Circe’ chapter of Ulysses that they finally evince something absurd and mysterious in human nature, whereas in In Search of Lost Time Proust more tightly aligns decadent traits with the burden of personal character and societal malaise. Mann, in underscoring both medical and metaphysical aspects of decadence, links with Joyce and Proust at many points. These prominent modernists reflect awareness of two basic polarities that first emerged in the decadent era of the fin de siècle: on the one side, concern over disintegrative forces in the modern world and realization of the need to take spiritual and aesthetic shelter; and, on the other, a sense of the aesthetic imperative to harvest the gains which the opportunity of such a moment presented.
From its emergence in the mid-nineteenth century, decadence has been, fundamentally, a socio-cultural response to urban modernity. Indeed, decadence is all but unthinkable outside the borders of the modern metropolis. Hence this chapter treats literature less as a literary critic would and more as an urbanist thinker might. An urbanist reading of a decadent text must perforce pay attention not only to urban geography, including the plan of the city in which the work is set, its dominant architectural styles, socio-economic differences in neighborhoods, and so on, but also to the cultural, social, and psychological meanings that the urban setting produces in a particular decadent text. In this essay, the urbanist approach is brought to bear on three novels whose urban geography is especially significant to their respective narratives: Gabriele D’Annunzio’s Il Piacere [Pleasure] (1889), Oscar Wilde’s The Picture of Dorian Gray (1891), and Thomas Mann’s Der Tod in Venedig [Death in Venice] (1912). These three works illustrate, respectively, the special relationship of the urban scene to cultural, social, and psychological issues germane to the decadent narrative of each novel.
Repeated administration of intravenous immunoglobulin (IVIG) to improve the course of multiple sclerosis (MS) has now been tested in almost all stages of the disease, although to a variable extent and with various study designs. To date, two clinical trials have tested the effects of IVIG on progressive forms of MS. The efficacy of IVIG has been explored in several stages and settings of MS ranging from attempts to ameliorate the acute attack via investigations on the effects of long term immunomodulation to attempts of restoration of fixed deficits. Due to the good tolerability of IVIG, it has been recommended as a possible means to lessen disease activity that may be seen after delivery in some MS patients. The side effects observed at lower dosages of IVIG have been uniformly minor and consisted primarily of headaches, malaise, or a transient rash.
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