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Edited by
Laurie J. Mckenzie, University of Texas MD Anderson Cancer Center, Houston,Denise R. Nebgen, University of Texas MD Anderson Cancer Center, Houston
Leukemias represent a range of bone marrow disorders that are broadly differentiated into acute and chronic. Acute leukemias, characterized by the proliferation of immature blood cells (blasts) and defined by peripheral blood or bone marrow blast percentage of 20 percent or more, are aggressive hematologic malignancies that are universally fatal without treatment. Chronic leukemias are mature leukemias with differentiated cells. Obstetric and gynecologic complications pose significant risk to the patient. Knowledge regarding uterine bleeding, fertility planning, and the management of the pregnant patient with leukemia are necessary in order to appropriately address these patients. In this chapter, we briefly review both acute and chronic leukemias, epidemiology, diagnosis and management, obstetric and gynecologic complications, teratogenicity of chemotherapies utilized in the treatment of each leukemia and finally detail our approach to the management of these patients.
This chapter discusses the diagnosis, evaluation and management of small bowel obstruction (SBO). It details the specific types of small bowel obstruction. Common causes of small bowel obstruction include hernias, neoplasms, intussusception, and others. Thorough history should be taken, with particular attention paid to prior SBOs, abdominal surgeries, hernias, cancer, and opiate use. The vital signs of SBO are: fever, tachycardia, hypotension, and tachypnea. The examination of the abdomen is performed by visually inspecting the abdomen for scars and distension. Rectal examination is considered with evaluation for occult blood, although diagnostic yield may below and classically the rectal vault will be empty. In laboratory evaluation findings are not specific to bowel obstruction. Results may show evidence of dehydration, acidosis, renal failure, and leukocytosis. Antibiotics are indicated with evidence of ischemia, perforation, or severe disease, although there is no good evidence supporting or refuting the use of empiric broad-spectrum antibiotics.
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