An experimental study of the equation of state for metallic powders under impact loading was carried out at a high-energy laser facility. A laser-ablatable micro-target was obtained to satisfy the laser equation of state for experimental study, and the precise characterization of the initial density was realized. The technique boosts the pressure of copper powder to 1400 GPa. The data consistency can effectively distinguish the data trends under different initial densities (~4.05 and 4.50 g/cm3). Experimental data can effectively distinguish the differences between the high-pressure Thomas–Fermi model and the Thomas–Fermi–Kirzhnits model, providing strong support for the WEOS-Pα model of the Institute of Applied Physics and Computational Mathematics, which is more in line with the actual state description of the material. This experimental technique can be extended to study the high-pressure physical properties of other powder particles.