This essay traces the rise of ginseng as a crucial commodity in the Qing Dynasty, focusing on its integration into the empire’s administrative and economic structures. Central to this transformation was Pierre Jartoux’s influential identification of ginseng, which reoriented its trade from inland markets to maritime routes. This shift not only enhanced its global circulation but also broadened its accessibility to diverse consumers. The essay speaks to multiple fields of study. It contributes to global commodity history by highlighting how ginseng’s changing trade routes shaped early modern commerce. It also emphasizes the entangled nature of cultural and economic exchanges across regions. Additionally, it advances scholarship in the history of medicine by examining how ginseng’s therapeutic uses and meanings developed as it moved across different social and geographic contexts.