This study assessed the willingness of general dental practices (GDPs) toparticipate in research. All 263 GDPs in South East London that provide dentalcare under National Health Service (NHS) contracts were invited. The surveyinstrument was adapted from previous studies and piloted before administration.Geographical factors and practice characteristics associated with willingness toparticipate in research were explored in logistic regression models. A total of77 responses were received (response rate: 29%). Of them, 40 (53%)expressed interest in being involved in primary care research. They saw theirmain role as collecting data and facilitating access to patients. Time,bureaucracy and lack of energy were the main reasons behind a decision not toengage with research. Those spending more time in NHS services were more likelyto be willing to participate in research. Other possible indicators weresingle-handed GDPs, participation in the dental foundation training programmeand location in more affluent areas.