This study aims to identify (1) a core disruptive
behavior disorder (DBD) postulated to
presage a substance use disorder, and (2) the relative
importance of parental DBD
phenotypes, and familial and nonfamilial environmental
factors in the determination of
DBD in male children. DBD symptom counts and measures of
familial and nonfamilial
environmentals were collected from intact families
ascertained through the presence (SA+)
or absence (SA−) of substance dependence in
fathers. Multivariate analyses revealed that
both behavioral symptoms and environmental measures were
significant discriminators of
the families. In SA+ families, the child's score
DBD was best predicted by magnitudes of
parental dyssocial behaviors and by familial environmental
factors. However, in SA−
families only familial environmental factors were
significant predictors of the child's DBD.
These findings suggest that in addition to independent
actions of familial transmissible and
nonfamilial factors, strong genotype-environment
interactions may determine DBD in
children and that may contribute to the liability for a
substance use disorder.
Abbreviations: ADD: attention-deficit/hyperactivity
disorder; ASPD: antisocial personality disorder; CD:
conduct disorder; DBD: disruptive behavior disorder; K-SADS-E;
author to supply; NCI: Neighborhood Cohesion Index;
ODD; oppositional defiant
disorder; PSUD: psychoactive substance dependence disorder;
SA: substance dependence
(+=present, −=absent); SCID: Structured Clinical
Interview for DSM-III-R; SUD; substance use disorders.