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It has been well known that air pollution and sleep deprivation individually have impacts on human health; however, the association between the two has not been well researched. The aim of this study was to investigate this relationship at a community level.
Methods
We collected sleep outcomes from the Korean Community Health Survey between years of 2008 and 2016. The data contained 1 130 080 selected adults aged ⩾ 19 years, from 141 communities. As sleep outcomes, annual chronic sleep deprivation (% of people who sleep ⩽ 5 h per day on average) and average values of daily mean sleep duration were used. Community-specific annual averages of particulate matter with a diameter ⩽ 10 μm (PM10), nitrogen dioxide (NO2) and carbon monoxide (CO) were collected and then applied to a linear mixed effects model to estimate the association between air pollution over the past 4 years and sleep outcomes. Population density, green space, health behaviour, and gross regional domestic product per capita variables were considered as confounders in all mixed effect models.
Results
From the linear mixed effect models, we found that the chronic sleep deprivation % was positively associated with PM10 (0.33% increase with 95% CI 0.05–0.60; per 10 μg/m3) and NO2 (0.68% with 95% CI 0.44–0.92; per 10 ppm). Higher PM10 and NO2 were also associated with shorter sleep duration, with a reduction of 0.37 min (95% CI −0.33 to 1.07 min; per 10 μg/m3) and 2.09 min (95% CI 1.50–2.68 min; per 10 ppm), respectively. The associations between PM10 and sleep outcomes were higher in females than males and in the older age groups (⩾ 60-years) than in younger age groups (19–39 and 40–59 years). However, the association between NO2 and sleep outcomes were more higher in males than in females and in the younger age groups (19–39 years) than other age groups.
Conclusions
Our findings provide epidemiological evidence that long-term interventions to reduce air pollutions are anticipated to provide improvements in sleep deficiency.
This chapter reviews the relative abuse liability of the various stimulant medications used to treat impairments associated with chronic sleep deprivation and how the drugs' potential for abuse impacts their medical usefulness. The abuse liability of a drug is an important consideration during the drug development process, when estimating risk: benefit ratios for approving drugs, and ultimately in the prescription and utilization of a drug by physicians and patients. The physicochemical properties of a drug determine how it may be administered and its pharmacokinetic profile. The mesolimbic dopamine system has been identified as a key pathway involved in mediating the properties of drugs that are responsible for their addictive nature. The behavioral effects of drugs evaluated in abuse liability studies include reinforcing effects and discriminative stimulus effects. Amphetamine is readily self-administered and discriminated by animals, and often used as a positive control drug in studies of abuse liability.
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