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In this chapter, we review empirical and conceptual work pertaining to organic changes in the brain and shifting goals as contributors to age-related changes in affective processing. We argue for the need to integrate these two previously isolated lines of research by delineating their crucial interplay toward a comprehensive understanding of affective neuroscience in aging. We present examples of aging trajectories, impacted by organic brain and motivational change, to identify key processes of interest for future research and potent intervention targets to promote successful aging. We conclude with open basic and applied research questions embedded within our integrated conceptual framework to guide future research on affective neuroscience in aging.
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