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5 results

  • Morphological evidence of biofilm in chronic obstructive sialadenitis

  • S A Schrøder, S Eickhardt, T Bjarnsholt, T Nørgaard, P Homøe
  • Journal:
    The Journal of Laryngology & Otology / Volume 132 / Issue 7 / July 2018
    Published online by Cambridge University Press:
    10 July 2018, pp. 611-614
    Print publication:
    July 2018
  • Objective

    Bacterial infection is a common finding in acute sialadenitis and may play a role in the chronicity of the condition. This study investigated if bacterial biofilm is present in submandibular chronic obstructive sialadenitis.

    Methods

    A descriptive case–control study was conducted that compared 10 histological sections of submandibular glands with chronic obstructive sialadenitis, to 10 histological sections of the healthy part of submandibular glands with pleomorphic adenoma. Fluorescence in situ hybridisation and confocal laser scanning microscopy visualised evidence of bacterial biofilm.

    Results

    In the chronic obstructive sialadenitis group, 5 out of 10 histological sections showed morphological evidence of bacterial biofilm. In the control group, there was no sign of bacterial biofilm formation.

    Conclusion

    Morphological evidence of bacterial biofilm was found in the submandibular gland sections from patients with chronic sialadenitis and suggests a role in the chronicity of submandibular chronic obstructive sialadenitis.

  • Does saliva composition affect the formation of sialolithiasis?

  • S A Schrøder, P Homøe, N Wagner, A Bardow
  • Journal:
    The Journal of Laryngology & Otology / Volume 131 / Issue 2 / February 2017
    Published online by Cambridge University Press:
    15 December 2016, pp. 162-167
    Print publication:
    February 2017
  • Objective:

    Saliva composition may affect sialolithiasis formation; thus, this study compared the salivary inorganic composition of sialolithiasis patients with that of healthy controls, and determined whether salivary inorganic composition changes after sialolithiasis surgery.

    Methods:

    The study included 40 patients with sialolithiasis and 40 matched healthy controls. Patients were examined before and after sialolithiasis surgery; controls were examined once. Flow rate and the inorganic saliva composition in unstimulated whole saliva were assessed.

    Results:

    Patients’ salivary flow prior to surgery was significantly lower compared to that of healthy controls, but equalised after surgery. Prior to surgery, patients’ saliva exhibited higher concentrations of calcium, magnesium, phosphorous compared to that of healthy controls. The concentration of most ions remained high after sialolithiasis surgery.

    Conclusion:

    Sialolithiasis patients had increased salivary concentrations of the ions that constitute the main inorganic phase of most sialoliths, and this may confer a risk for developing sialolithiasis.

  • Pulsed dye laser lithotripsy of submandibular gland salivary calculus

  • Hirotaka Ito, Shunkichi Baba
  • Journal:
    The Journal of Laryngology & Otology / Volume 110 / Issue 10 / October 1996
    Published online by Cambridge University Press:
    29 June 2007, pp. 942-946
    Print publication:
    October 1996

  • An in vivo study was performed to evaluate the use of pulsed-dye laser beam for the fragmentation of salivary calculus. In accordance with the absorption and reflection spectra of sections of salivary stones, optimal fragmentation was achieved with a pulsed-dye laser with a pulse width of 1.4 μm and tuned to a wavelength of 504 nm. Further studies on particle size were conducted, and a new “sialoendoscope” technique was developed. Fifteen patients with sialolithiasis of the submandibular gland were treated. Under continuous endoscopic monitoring laser-induced shock wave lithotripsy was performed. In six patients complete fragmentation and removal of the salivary stones was achieved and in another patient 50 per cent fragmentation was sufficient to restore salivary flow. Laser lithotripsy of salivary stones with endoscopic monitoring permits treatment on an outpatient basis with little inconvenience to the patient, and this is a breakthrough in otolaryngology.