Although the Mixteca region has witnessed a long period of human occupation from before village societies were established to the present, traditional archaeological narratives tend to simplify this history by emphasizing singular points of origin and radical moments of change. Based on decolonial perspectives, we examine how persistence may be a more suitable framework for understanding the long history of human occupation in the region. Using information from three archaeological projects, this article analyzes the enduring histories of household practices at the site of Etlatongo in the Nochixtlan Valley. We focus on the construction of domestic spaces over three different periods in the long occupation of the site: during the latter half of the Early Formative (1400–1000 BC), the late Middle Formative (500–300 BC), and the Postclassic (AD 900–1500s). By analyzing the changing continuities of domestic practices at Etlatongo, this study contributes to scholarship examining the persistence of Indigenous communities in Mesoamerica.