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Edited by
Rebecca Leslie, Royal United Hospitals NHS Foundation Trust, Bath,Emily Johnson, Worcester Acute Hospitals NHS Trust, Worcester,Alex Goodwin, Royal United Hospitals NHS Foundation Trust, Bath,Samuel Nava, Severn Deanery, Bristol
This chapter covers drugs affecting the cardiovascular system in three distinct sections. Firstly we discuss antihypertensive agents, those used in anaesthesia and critical care, and those used in the community. We then go on to discuss antiarrhythmic agents and the Vaughan-Williams classification, with additional focus on digoxin and amiodarone. Finally we discuss inotropic and vasopressor drugs, both essential knowledge for the exam and clinical practice.
Edited by
Dharti Patel, Mount Sinai West and Morningside Hospitals, New York,Sang J. Kim, Hospital for Special Surgery, New York,Himani V. Bhatt, Mount Sinai West and Morningside Hospitals, New York,Alopi M. Patel, Rutgers Robert Wood Johnson Medical School, New Jersey
The cardiovascular pharmacology chapter focuses on therapeutic agents utilized by anesthesiologists in the treatment of a myriad of pathologies encountered in the operating room environment and elsewhere. The chapter provides a succinct outline of major classes of cardiovascular drugs that are an integral part of the practice of anesthesiology. The aim of the chapter is to deliver said material in an easy to read format to those preparing for board examinations and as a review for the practicing anesthesiology resident physician
To assess the effectiveness of the use of dobutamine hydrochloride in out-of hospital emergency situations.
Population:
Patients with severe circulatory insufficiency caused by acute illness or injury encountered by the Mobile Intensive Care Unit of Copenhagen (population 467,000) during a 15-month study period.
Methods:
A newly developed dobutamine solution was administered by infusion pump to patients in whom normal emergency treatment failed to restore an acceptable circulatory state.
Results:
A total of 40 patients were treated with 4–48 μg dobutamine/kg/minute. The treatment was judged to be primary life-saving in 15 patients, the condition was improved in 16 patients, and nine patients died. Systolic blood pressures (in those who survived) rose from a mean value of 45 mmHg (range 0–80 mmHg) to 105 mmHg (range 65–180 mmHg). No tachycardia or arrhythmias were noted.
Conclusion:
This newly developed dobutamine solution is very useful in prehospital treatment of patients with circulatory failure and is recommend for use by mobile intensive care unit teams.
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