In her contribution, Valerie J. Bradley explores the unique and powerful importance of the right to science for people with intellectual, physical and mental health disabilities. The human rights of people with disabilities articulated in the Convention on the Rights of People with Disabilities (CRPD) (2006) directly connect to the principles and aspirations of the right to science. As noted in the 2014 meeting of the American Association for the Advancement of Science on Disability Rights and Accessing the Benefits of Scientific Progress and Its Applications, access to science and technology can have both a positive and negative impact on the rights of people with disabilities. Bradley begins with a review of the human rights of people with disabilities both in the CRPD and articulated and reinforced in public policy and judicial rulings. Those rights, which have specific affinities to the right to science, include the ability to live independently, to be employed, to enjoy health and well-being, to receive adequate education, to have access to habilitation and rehabilitation, and to be free from degrading treatment. The intersection of the right to science and its applications and the realization – or abridgement – of these rights are explored. Further, the unique vulnerability of people with disabilities as subjects of scientific research and experimentation, including a history of exploitation and the application of now discredited interventions, are described, just as the barriers, physical as well as educational, to people with disabilities as students and practitioners of science are examined. Finally, for people with disabilities, access to technology holds the promise of more independent functioning, a re-examination of the construct of disability, and increased community participation.