The results of the taxonomic, taphonomic, and paleoecological analyses of Late Pleistocene micromammals from the Salto de Piedra paleontological locality are presented in this paper. Our results support the conclusion that the microfaunal remains were mainly accumulated by diurnal raptors in areas close to where the remains were deposited, as there is no evidence of transport. Taxonomically, the recovered micromammals include rodents currently inhabiting the Humid Pampa (Calomys cf. C. musculinus-laucha, Ctenomys sp., and Reithrodon auritus) and species that became extinct during the Late Pleistocene (Microcavia cf. M. robusta) and Holocene (Galea tixiensis). Additionally, remains of the Patagonian marsupial Lestodelphys halli and the amphibious sigmodontine Holochilus brasiliensis were identified. These analyses, along with the paleoecological and malacological studies at Salto de Piedra, confirm a trend toward increased humidity, consistent with the paleoenvironmental evidence documented for the region at the end of the Pleistocene. This study of the central Humid Pampa based on this small mammal record is of particular interest for interpreting the paleoenvironmental and paleoecological scenario, coinciding with the arrival of the first humans in the area and the extinction of the megafauna.