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1 results

  • Marrow proliferation as a cause of hearing loss in beta-thalassaemia major

  • D Thio, V Prasad, P Anslow, P Lennox
  • Journal:
    The Journal of Laryngology & Otology / Volume 122 / Issue 11 / November 2008
    Published online by Cambridge University Press:
    12 October 2007, pp. 1253-1256
    Print publication:
    November 2008
  • Objective:

    The aim of this report was to highlight the fact that hearing loss in thalassaemia patients can be related to marrow expansion affecting the ossicles, resulting in a conductive loss.

    Case report:

    A six-year-old boy with transfusion-dependent beta-thalassaemia developed a unilateral hearing loss shortly after commencing desferrioxamine therapy. Otoxicity was assumed, but the deficit was later found to be of a conductive nature, due to marrow proliferation within the ossicular chain as a consequence of the disease process – a phenomenon previously unreported in the literature.

    Conclusion:

    It is important to elucidate the precise nature of new onset hearing loss in patients receiving iron chelation therapy, in order to avoid unnecessary cessation of much needed medication, on the assumption of ototoxicity.