Greenhouse and field experiments were conducted in Kansas to test various postemergence herbicides for crop safety and weed control in pearl millet. Five pearl millet hybrids were used in greenhouse experiments and three hybrids (Hyb1, Hyb-2k, Hyb-3k) were used in field experiments at two sites. All herbicides were found to be safe (1% to 5% injury) for use on all pearl millet hybrids in both greenhouse and field experiments at 28 d after application (DAA), except imazamox and nicosulfuron, which were noted to cause 22% to 35% injury. At Site 1 at 42 DAA, 2,4-D, dicamba, bromoxynil + pyrasulfotole, 2,4-D + bromoxynil + fluroxypyr, and dicamba + 2,4-D effectively controlled Palmer amaranth by 88% to 91%, and density was reduced to 2 to 4 plants m−2 compared with 18 plants m−2 in nontreated control plots. The least control (60% to 65%) and greatest density (8 plants m−2) of Palmer amaranth was observed after applications of imazamox and nicosulfuron. In contrast, green foxtail was effectively controlled by 91% to 92%, and density was reduced to just 2 plants m−2 when imazamox and nicosulfuron were applied, whereas 13 plants m−2 were recorded in a nontreated control plot at 42 DAA. No weed emergence was observed at Site 2 regardless of treatment, including nontreated plots. High grain yields were recorded (Hyb1, 3,866 to 4,619 kg ha−1; Hyb-2k, 2,222 to 3,699 kg ha−1; and Hyb-3k, 822 to 1,315 kg ha−1) at both sites after applications of 2,4-D + bromoxynil + fluroxypyr. These results highlight that the postemergence herbicides tested in this study, except imazamox and nicosulfuron, can be safely used for weed control in fields of pearl millet.