HIV/AIDS posed a significant health threat in Denmark from the early 1980s until the end of the 1990s, claiming approximately 2,000 lives. Gay men, hemophiliacs, drug users, sex workers and migrants were overwhelmingly among the victims of the disease. They also constituted the groups most associated with it. This led to a raised level of public attention to these groups; a heightened visibility that ambiguously resulted both in improving the life conditions of some while also increasing the stigma of others. This article analyses the roles of different cross-sector actors in shaping the responses to HIV/AIDS in Denmark, with each group influencing and being influenced by the epidemic. Yet despite the clear connection between HIV/AIDS and the minoritized, often marginalized, groups, the article argues that the overarching and dominant response objective during the crisis in Denmark was to prevent a heterosexual epidemic. Throughout the crisis, other responses, aims and objectives concerning the groups most affected by HIV/AIDS could be, and did become, contingent with this dominant objective. The strengths and positions of those subresponses depended on, however, the perceptions of them as logical and tangible means to the primary end of preventing the heterosexual epidemic. Pulling together different and changing responses from different and changing actors serves to crystallize what objectives or logics are the mutual ones, and the significance of this analysis is that what appeared to be a very heterogeneous set of responses to the disease in Denmark, was in fact rooted in the same objective. Notably, the perceived pertinence of preventing the heterosexual epidemic was not rooted in actual rates of infection or spread of the disease.