We made a mistake in Fig. 4 due to an abnormality in the order of the statistical parameters in the software (Stata 12.0 with ado-file metan)
Our statistician used an incorrect calculation by mistake:
(N_treat/(N_treat+N_contr)) : (event_treat/(event_treat + event_contr)
instead of:
(event_treat/N_treat) : (event_contr/N_contr)
The error does not have any impact on the results, but
Fig. 4(a), (b) did not show the correct data. Here are the recalculated correct figures(Reference Doege, Grajecki and Zyriax1).

Fig. 4(a)

Fig. 4(b)