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Drug use among young women in Pakistan: A qualitative study of socioeconomic and psychological perspectives

Published online by Cambridge University Press:  13 October 2025

Muhammad Suhail Khan*
Affiliation:
Department of Sociology, School of Sociology and Political Science, Anhui University , Hefei, P.R. China
Yao Dewei
Affiliation:
Department of Sociology, School of Sociology and Political Science, Anhui University , Hefei, P.R. China
Wu Zongyou
Affiliation:
Department of Sociology, School of Sociology and Political Science, Anhui University , Hefei, P.R. China
Aman Khan
Affiliation:
Department of Sociology, School of Public Administration, Hohai University , Nanjing, P.R. China
Ibrahim
Affiliation:
Department of Sociology, University of Malakand, Khyber Pakhtunkhwa, Pakistan
Anastasiia Pavlova
Affiliation:
Department of International Trade, School of Economics, Anhui University , Hefei, P.R. China
*
Corresponding author: Muhammad Suhail Khan; Email: sohail.khattak1@yahoo.com
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Abstract

Drug use among young women has severe consequences for their mental health, increases their developmental vulnerability and highlights the global problem of drug addiction. The purpose of this study was to investigate the socioeconomic and psychological factors influencing drug use among young women in Khyber Pakhtunkhwa, Pakistan. The study used a qualitative research design. We collected data from 12 women aged 18–21 years via in-depth qualitative interviews conducted in Mardan and Peshawar from March to June 2022. Research shows that young women frequently use drugs due to peer pressure, emotional challenges and financial concerns, which significantly impact their lives. The study emphasizes the value of cultural intervention programs for young women, concentrating on the region’s mental health services, economic empowerment and gender-specific peer support networks.

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Type
Research Article
Creative Commons
Creative Common License - CCCreative Common License - BY
This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0), which permits unrestricted re-use, distribution and reproduction, provided the original article is properly cited.
Copyright
© The Author(s), 2025. Published by Cambridge University Press

Impact statement

In this study, we examine the drug use among young women and their socioeconomic status, psychological characteristics and cultural influences in the Khyber Pakhtunkhwa province of Pakistan. The call for culturally sensitive and gender-sensitive approaches lays the foundation for the development of targeted treatment and public health programs. The results point to the need for comprehensive mental health care, community outreach and educational programs targeting youth in patriarchal societies. This approach challenges the stigma surrounding drug use and contributes to a more profound understanding of drug dependence as a multifaceted public health problem. This study contributes to global debates on gender, drug policy and health equity, and it suggests that similar strategies should be applied in other conservative contexts.

Introduction

Drug use and addiction represent significant public health issues, with extensive consequences for people, families and communities. The World Health Organization states that drug use results in millions of deaths each year, facilitates the transmission of infectious diseases such as human immunodeficiency virus and hepatitis C, and aggravates chronic health conditions (Lemahieu and Me, Reference Lemahieu and Me2014; Lanini et al., Reference Lanini, Easterbrook, Zumla and Ippolito2016; World Health Organization, 2018; Scheibe et al., Reference Scheibe, Young, Versfeld, Spearman, Sonderup, Prabdial-Sing, Puren and Hausler2020; Verma et al., Reference Verma, Kumar, Saha, Dutta and Singh2020). Women are more prone to relapse, withdrawal symptoms and negative social consequences than men (Sun, Reference Sun2007; Catalano et al., Reference Catalano, Fagan, Gavin, Greenberg, Irwin, Ross and Shek2012). Socioeconomic and cultural determinants affect drug use, leading to marginalization and restricted access to healthcare (Khan, Reference Khan2011; Farrington et al., Reference Farrington, Roderick, Allensworth, Nagaoka, Keyes, Johnson and Beechum2012; Carpenter, Reference Carpenter2015).

The increasing frequency of drug use, especially among the youth in Pakistan, is a substantial health risk to the country. Over 6.7 million individuals in Pakistan are involved in drug use. The most common drugs are cannabis, heroin and amphetamines (Farooq et al., Reference Farooq, Rasooly, Abidi, Modjarrad and Ali2017; Zada et al., Reference Zada, Shah, Saleem, Ashraf, Hameed and Yousaf2022). Approximately 25% of teenagers consistently use cannabis, while growing tendencies such as crystal methamphetamine and sheesha smoking are prevalent in metropolitan areas and among middle-class demographics (Masood and Us Sahar, Reference Masood and Us Sahar2014; Atif et al., Reference Atif, Malik, Asif, Qamar-Uz-Zaman, Ahmad and Scahill2020). Unmanaged peer pressure, financial and mental health issues increase the likelihood of young individuals becoming drug addicts (Ahmed et al., Reference Ahmed, Wassan, Qadri and Ahmed2022). Cultural restrictions and gender norms in conservative regions impede drug use prevention and treatment efforts, requiring culturally tailored treatments for young women (van Solinge, Reference van Solinge2007; Khan et al., Reference Khan, Zongyou, Dewei, Khan and Pavlova2024).

According to Khan et al. (Reference Khan, Naz, Hu and Hussain2017), over a quarter of Pakistani teenagers are unaware of the harmful consequences of psychoactive drugs. The commencement of drug use among young individuals is influenced by several variables, including ignorance, social pressure, cultural expectations, familial relationships and feelings of isolation (Wolfe et al., Reference Wolfe, Jaffe and Crooks2008). The use of legal tobacco and alcohol often normalizes drug use among young individuals, with a notable correlation between alcohol intake and chronic illnesses, mental health issues and familial discord (Rose and Cherpitel, Reference Rose and Cherpitel2011). These patterns show that a mix of social and knowledge gaps makes young individuals more likely to engage in dangerous behavior. In this regard, the public’s education and problem-avoidance skills are of utmost importance (Khan et al., Reference Khan, Ding, Khan and Épiphanie2025).

The increase in drug availability in Pakistan, particularly in Khyber Pakhtunkhwa, can be attributed to the nation’s closeness to Afghanistan, which is recognized as the top opium producer globally (Ward and Byrd, Reference Ward and Byrd2004; Malik and Sarfaraz, Reference Malik and Sarfaraz2011). Pakistan exhibits one of the highest national rates of drug consumption globally, with more than 6.7 million individuals engaging in drug use (Zubair, Reference Zubair2015; Zada et al., Reference Zada, Shah, Saleem, Ashraf, Hameed and Yousaf2022). Earlier investigations (Ali, Reference Ali1999) demonstrated a typical pattern of cannabis usage, which persists in affecting the ongoing issue. It is alarming that nearly 700 individuals lose their lives each day in Pakistan due to drug-related problems (Dawn News, 2015). The report emphasizes the gravity of the drug issue and highlights the necessity of conducting studies within the community to develop targeted strategies for treatment and prevention.

Factors influencing youth substance use

The mental health of young individuals, their cognitive growth, social connections, familial relationships and socioeconomic status all contribute to their patterns of drug use (Preston et al., Reference Preston, O’Neal, Talaga and Moore2021). Drug use often escalates as a response to stress and emotional turmoil, influenced by socioeconomic factors like poverty, financial insecurity and inadequate education (Kandel et al., Reference Kandel, Kessler and Margulies1978; Ghate and Hazel, Reference Ghate and Hazel2002). Substance use serves as a means of coping for individuals facing poverty due to the limited social and educational opportunities available. The prevalence of drug use is heightened among individuals who experience inadequate emotional support from carers or come from families with a history of substance use (Farrell and White, Reference Farrell and White1998). Kilpatrick et al. (Reference Kilpatrick, Acierno, Saunders, Resnick, Best and Schnurr2000) indicate that young individuals often engage in substance use due to dysfunctional families, which are characterized by ineffective communication, parental discord and inadequate oversight.

Peer influence, family relationships and economic circumstances significantly shape the trends of substance use among young individuals (Marshall and Werb, Reference Marshall and Werb2010). Substance use and various risky behaviors are often encouraged within peer groups among young individuals to achieve social acceptance and a sense of belonging (Prinstein et al., Reference Prinstein, Boergers and Spirito2001). Many young individuals resort to substance use like alcohol and narcotics to manage stress, despair, anxiety and other mental health issues (Wills, Reference Wills1990; Khantzian and Albanese, Reference Khantzian and Albanese2008). The prefrontal cortex is crucial in young individuals for regulating impulses and making decisions. Individuals in development often engage in hazardous activities like substance use due to a lack of understanding of their consequences (Evans and Stanovich, Reference Evans and Stanovich2013; Giedd, Reference Giedd2015). Various factors influence the rise in drug usage, necessitating the use of targeted therapies to tackle these challenges (Sinha, Reference Sinha2001).

Methods

The study investigates the factors influencing drug use among young women in Khyber Pakhtunkhwa, Pakistan, focusing on social, psychological and economic factors. It aims to understand how these factors affect their drug use and contribute to their addiction.

Research questions

We pursued the following research questions: (1) How do social factors influence young women’s drug use? (2) How do psychological factors lead to drug use among young women? (3) How do economic factors contribute to drug addiction among young women?

Research design

The study utilized a qualitative research design. We recruited participants through snowball sampling. Data were collected from 12 in-depth qualitative interviews conducted in the cities of Mardan and Peshawar between March and June 2022.

Sampling and participant selection

Eligibility criteria included (1) identifying as a woman, (2) being between 18 and 21 years of age, (3) having a history of drug use (current, in recovery or ceased) and (4) demonstrating willingness and ability to share personal experiences in an interview setting. The evaluation of the screening process involved posing targeted questions to prospective participants, including inquiries like, “Are you at ease discussing your personal experiences with drug use?” And “Do you believe you are ready to speak candidly about the challenges you’ve encountered concerning substance use?”

The enthusiasm shown by participants in the study indicated their preparedness, as they expressed a desire to engage in the interview process. Participants were required to uphold both mental and physical stability to engage in the interview without facing immediate distress. At each stage of the interview, we assessed the participants to determine their readiness to proceed. We prompted the interview participants to share their experiences of feeling overwhelmed, anxious or physically uncomfortable. We provided the opportunity for individuals exhibiting signs of distress, such as panic attacks, severe anxiety or physical discomfort, to pause the interview and take a break. We ended the interview and removed the participant from the study to prioritize their well-being if they showed signs of distress. Participants had to reside in Mardan or Peshawar, and all participants were required to provide informed consent before participating in the study. Participants were required to be prepared to share their experiences and maintain mental and physical stability to avoid distress during an interview.

The original intention for the final sample size did not include getting 12 people to participate. The sample size was determined continually, according to the concept of data saturation. We continued to hire people until we reached saturation, and after each session, we reviewed the interviews. Data gathering stopped when no new themes or important insights came up. The research team assessed theoretical saturation throughout the data collection phase by analyzing transcripts from each interview and evaluating the feasibility of integrating further material. The method included evaluating both recognized topics, such as socioeconomic variables influencing drug use, and emergent themes that arose during interviews, including emotional coping techniques and social support systems. Recruiting participants for the study proved challenging due to the sensitive nature of the issue, forcing the researchers to rely on snowball sampling through local networks. The study drew in 12 participants, thereby presenting a diverse range of perspectives.

We identified our first participants by networking with individuals we knew who worked in addiction treatment, community health and social work. The study involved rehabilitation centers, local non-governmental organizations (NGOs) and community health clinics that assist individuals dealing with drug use issues. We examined the institutions’ direct engagement with individuals struggling with addiction and the effectiveness of their treatment programs. These organizations and our team successfully collaborated due to our professional connections, past partnerships and discussions with specialists in the field. Social workers and healthcare professionals identified individuals who met the criteria and expressed a willingness to take part in the study. In this study, the snowball sampling method was employed. Scholars may connect with marginalized communities and gather a rich array of qualitative data through the snowball sampling method (Dusek et al., Reference Dusek, Yurova and Ruppel2015). Employing snowball sampling methods tends to increase individuals’ engagement in social networks (Cohen and Arieli, Reference Cohen and Arieli2011).

(Table 1): A sample of 12 participants (n = 12) was available during the interview. Seven participants (n = 7) were interviewed in Mardan, while five (n = 5) were interviewed in Peshawar. Due to participant availability and accessibility, Mardan had a slightly higher number of participants, which was attributed to stronger connections with local healthcare practitioners and social workers who assisted in the recruitment process. All the participants were women. The participants varied in age, ranging from 18 to 21 years. Participants’ educational backgrounds varied, with some having completed primary or middle school and others being illiterate. This pattern reflects national trends, with female literacy rates lower in Pakistan, especially in Khyber Pakhtunkhwa. Out of the total, four participants (n = 4) had completed primary school, six (n = 6) had finished middle school and two (n = 2) were illiterate. Four participants (n = 4) were students, seven (n = 7) were unemployed and one (n = 1) had a job. Most participants came from low socioeconomic backgrounds, characterized by financial instability, limited educational opportunities and high unemployment rates.

Table 1. Demographic and drug use status of participants

Table 2: During the interviews, two individuals (n = 2) reported that they had ceased drug use; one had maintained abstinence for 6 months, while the other had done so for nearly a year. Both individuals have a history of using cannabis and crystal methamphetamine, with one also having previously used opioids. Four (n = 4) were currently undergoing a recovery treatment program at community-based centers, where they received counseling, medical support and behavioral therapy for detoxification, relapse prevention and psychological counseling. Meanwhile, six participants (n = 6) were still using drugs. Individuals reported using various substances, including cannabis, crystal methamphetamine and heroin, and often engaged in the simultaneous use of multiple substances, influenced by factors such as availability, peer pressure and personal coping strategies. The individuals involved were residents of Khyber Pakhtunkhwa, particularly from Mardan and Peshawar, two cities located in Pakistan.

Table 2. Types of substances used by participants (N = 12)

The interview protocols

After explaining the nature of the research project to potential participants and undergoing a thorough ethical review process that emphasized the sensitivity of the data and the sample size, we successfully obtained the required approvals from the study participants in the cities of Mardan and Peshawar. Using snowball sampling, we identified more potential participants who met the study’s data collection criteria through referrals from our initial contacts. For this reason, we conducted interviews with these individuals to verify that they were familiar with the project’s rules and goals. We maintained high ethical standards by promising to keep their information private throughout the research. Given their safety and comfort for attendees, locations such as private schools and community centers were chosen. The intention behind selecting this location was to foster cross-cultural understanding and ensure that all participants felt at ease expressing themselves openly.

Interview process

It is important to note that cultural norms and traditions in Khyber Pakhtunkhwa, combined with the segregated society, restrict male individuals from directly engaging with female participants. In this regard, female assistants, equipped with a profound understanding of qualitative analysis and data collection, helped carry out the interviews. We selected these female assistants due to their relationships with the participants and their insight into the cultural context. Research assistants fluent in both English and Pashto ensured the accuracy of the translation and transcription of participants’ work. Interviewers demonstrated exceptional competence in discussing sensitive topics such as substance use and gender dynamics in public health. The interview guides for the study were developed based on a thorough review of the existing literature. We consulted experts in gender studies, public health and psychology to ensure that questions were appropriate, culturally sensitive and reflective of the participants’ experiences. Guides were first written in English and then translated into Pashto for improved comprehension and clarity.

We created a series of cross-questions to investigate the backgrounds of individuals who are struggling with substance use. Through open-ended interviews, we examined the social, economic and psychological factors contributing to drug addiction among young women. We investigated the participants’ drug usage, behaviors and choices. The qualitative data collected through this method highlighted the various factors contributing to drug addiction in this context. We divided the interviews into four distinct sections. In the initial section, we inquired about factors such as age, educational attainment, family structure and living arrangements. The second section explored the various societal factors that influence drug use in young women. The third section discusses the intricacies of substance use and its underlying mental causes. The fourth section explored the field of economics.

Every 3-h interview was recorded with the participant’s consent. We ensured the accuracy of the data by carefully transcribing the recordings and conducting a thorough probing. The questions were simple, which facilitated a more in-depth exploration of emotions and reflections. We conducted additional probes to expand our understanding of drug addiction and our questions. Before the interviews began, each participant reviewed a detailed consent form with the interviewer. Each participant voluntarily signed the consent form, confirming that they understood the objectives of the study and felt comfortable with their participation. Participants were assured of confidentiality to encourage open and honest discussion. Interviews were initially conducted in Pashto, the participants’ native language, and then translated into English. No study participant received any specific compensation. Participants were thanked for their time and effort in the form of refreshments and reimbursement of travel expenses.

Data analysis

We used a grounded-theoretic approach to social theory and social structure to examine the interview data, following Merton’s (Reference Merton1968) suggestion, by searching for repeating themes. The interviews were transcribed verbatim by trained research assistants who were fluent in both Pashto and English. Transcriptions of the Pashto interviews were subsequently translated into English for research. Two researchers double-checked the transcripts against the original audio recordings to ensure their accuracy before completing the data for coding. Both individuals independently classified each transcript to ensure consistency and remove any potential for bias. The coding technique was followed by comparing codes and resolving any differences. A third senior member reviewed the transcript and attempted to resolve any disagreements among the team. We built a framework that efficiently structured all the data by using codes and categories.

We then employed inquiry questions, methodological design and field observations to create a thematic framework for the data. The interview transcripts were systematically coded in alignment with the pre-identified themes. We undertook a thorough analysis and interpretation of the structured data, carefully categorizing variables including age, gender and occupation. A comprehensive study was conducted on the categories, featuring an in-depth review of the insightful quotes shared by the respondents to verify the authenticity of the interviews. Prominent themes that surfaced include the backgrounds of the participants, the impact of peer groups, challenges related to mental health and issues surrounding financial difficulties or unemployment. We engaged with the participants and examined elements influencing their substance dependence through the lens of social identity theory (Hogg, Reference Hogg2016), social learning theory (Bandura and Walters, Reference Bandura and Walters1977), cognitive dissonance theory (Morvan and O’Connor, Reference Morvan and O’Connor2017), self-medication theory (Khantzian, Reference Khantzian1987) and strain theory (Agnew, Reference Agnew1992). We conduct a thorough analysis, literature review and theoretical frameworks to explore the experiences of young women in drug use.

Ethics consideration

We ensured confidentiality of interview transcripts by assigning unique study IDs, removing personally identifiable information during transcription, securely storing data in a password-protected database and deleting audio recordings post-transcription, ensuring participants’ responses were only used for research purposes.

Findings

The findings reveal the influence of peer groups, mental health issues, financial difficulties or unemployment, followed by social, economic and psychological factors. Thematic analysis of interview data reveals the following findings, with several participants sharing their experiences.

The influence of peer groups

Participants frequently emphasized the role of peers in initiating and sustaining substance use. Social gatherings, peer pressure and group activities often created pressure to experiment with drugs, particularly when refusal risked weakening relationships.

During my first experience at a social gathering with a friend and her colleagues, I made the unwise decision to take ice (crystal meth) in an attempt to fit in with the prevailing atmosphere, as it seemed many others were behaving similarly.” (Participant 2)

My best friend started using different drugs and constantly offered it to me." After a few instances of saying “no,” it became more challenging to deny without experiencing discomfort. I felt we wouldn’t be as close if I didn’t join.” (Participant 5)

My friends’ seemingly pleasurable experiences under the influence of substances piqued my interest. Their laughter and carefree demeanor gave the experience an appealing look, making me curious about the effects firsthand. This curiosity sparked a desire within me to give it a try, to see if it could provide me with the same feeling of euphoria and escape that they appeared to be experiencing.” (Participant 8)

A friend of mine introduced me to vaping, which started my journey into addiction. We regularly participate in events together, and over time, the habit became increasingly crucial to both of us.” (Participant 9)

Our friendship began with minor issues and evolved into a complex relationship. As we became more daring, we experimented with harder drugs, heightened our connection to substance use, and complicated our relationship with risky behaviors.” (Participant 11)

The narratives emphasize the significant role of peer pressure and social influence on drug use. Individuals often imitate their peers’ behaviors to avoid rejection and maintain relationships. Social identity theory suggests that individuals may use drugs to conform to a group’s identity, while cognitive dissonance theory suggests that individuals may change their attitudes.

Mental health issues

Participants frequently described using substances to cope with anxiety, stress and emotional struggles. Drugs and medications were seen as temporary solutions that provided immediate relief, even if the effects were short-lived.

I had a hard time coping with the pressure of school, especially the days before exams. It was a considerable sum. I started taking drugs that someone had given me at a party to help me deal with my anxiety and control my emotions.” (Participant 3)

Every day, the very act of thinking about the day ahead made me anxious. Smoking seemed to help ease that anxiety, if only for a few hours.” (Participant 4)

Whenever I experienced anxiety attacks, they were truly debilitating. Even though they were not prescribed to me, I found that some medications gave me immediate comfort. I just continued to rely on them to get through the day.” (Participant 7)

Coping with the daily demands, I found myself constantly on edge. A friend who found out about this offered me a joint. At first it was helpful, but soon I was smoking every day to feel normal.” (Participant 8)

My despair was only compounded by the loneliness I felt, which led me to turn to drugs as a means of short-term escape when I had no one else to turn to. They gave me a short-term boost to my mood and a sense of friendship, which helped to fill the emptiness I felt inside. Even though I knew it was harmful, I couldn’t resist the short-term comfort they offered.” (Participant 10)

My mood swings were unpredictable; they would soar high one minute and crash the next. Even though I was aware of the potential consequences, I resorted to medication to restore balance. Because I tended to act impulsively, I regularly made hasty choices, and medication was no exception. It gave me an easy way out of overwhelming feelings, but I often regretted my decision when the consequences began to take their toll.” (Participant 11)

The interviews reveal a rise in substance use as a coping mechanism for anxiety and stress, especially academic pressure, leading to a harmful addiction cycle. They point out that there must be interventions focusing on emotional regulation and impulse control to address underlying anxiety and stress.

Financial difficulties or unemployment

Participants reported financial hardship, unemployment and unfulfilled ambitions as factors contributing to substance use, often presenting drugs as a temporary escape from poverty and job loss.

After I was laid off, I began to feel depressed as my expenses continued to mount, leaving me feeling trapped. Even if it were only for a short period, I would turn to drugs to escape my money worries. Growing up in a time of constant scarcity, I found myself drawn to people who used drugs to find pleasure despite the hardships they were experiencing. Soon, I began using drugs myself, seeking a similar escape from the unrelenting weight of financial constraints.” (Participant 4)

I could not afford college and witnessed my friends depart for further education. My sadness and frustration at being abandoned and not achieving my goals drove me to drugs. The immense stress and instability I experienced at home due to both my parents losing their jobs during the recession further pushed me to use drugs as a means of coping.” (Participant 8)

My self-esteem plummeted after a year of unemployment, and I turned to drugs as my only source of happiness. Losing my job felt like losing part of myself, and to numb the pain of feeling worthless, I began using drugs more frequently. What started as an escape quickly became a daily necessity as my unemployment dragged on.” (Participant 9)

I experienced constant financial instability, reverting to old patterns after setbacks. Drugs became my coping mechanism, providing a temporary sense of control and relief from uncertainty.” (Participant 12)

Narratives show individuals coping with emotional and financial challenges through substance use, resource reduction or a combination of both, emphasizing the need to address economic and social factors to reduce drug use.

Discussions

This study illuminates the complex interactions of socioeconomic, psychological and social factors that affect drug use among young women in Khyber Pakhtunkhwa. Given that individuals frequently come across substances through their social circles and interactions, relationships with peers significantly influence the onset of drug use. Resistance can result in social marginalization or diminished social connections (Steinberg et al., Reference Steinberg, Fletcher and Darling1994; Farrington et al., Reference Farrington, Roderick, Allensworth, Nagaoka, Keyes, Johnson and Beechum2012). Reports from young women regarding changes in behavior aimed at alleviating social stress align with cognitive dissonance theory (Morvan and O’Connor, Reference Morvan and O’Connor2017) and social learning theory (Bandura and Walters, Reference Bandura and Walters1977), which suggests that behaviors are acquired through observation and imitation. Research by Henneberger et al. (Reference Henneberger, Mushonga and Preston2021), Piña et al. (Reference Piña, Namba, Leyrer-Jackson, Cabrera-Brown and Gipson2018) and Prinstein et al. (Reference Prinstein, Boergers and Spirito2001) shows that peer influence significantly predicts drug use among young individuals. This highlights the importance of preventive initiatives that incorporate peer groups, such as those educating on refusal skills and providing peer-led information.

Psychological distress has been acknowledged as a significant factor influencing drug use behaviors (Hawkins et al., Reference Hawkins, Catalano and Miller1992; Goldberg, Reference Goldberg2012; Carpenter, Reference Carpenter2015). Participants reported that they used drugs to manage stress, worry, schoolwork, loneliness and mood swings. These narratives align with the self-medication theory (Khantzian, Reference Khantzian1987; Kaminer et al., Reference Kaminer, Bukstein and Bukstein2011), which posits that individuals use drugs as an ineffective means to alleviate psychological pain (Wills, Reference Wills2013; Seaward, Reference Seaward2017). Narratives elucidating impulsive behavior amid mood variations further substantiate the correlation between impulsivity and addiction risk (World Health Organization, 2004; Perry and Carroll, Reference Perry and Carroll2008; Smith and Cyders, Reference Smith and Cyders2016). These results underscore the need to integrate mental health services into both preventative and treatment programs, highlighting treatments that promote stress management, emotional regulation and impulse control. This discovery is essential in traditional contexts where mental health services are difficult to come by and negative ideas about mental health persist.

The prevalence of drug use was notably higher among individuals facing economic difficulties and unemployment. Participants indicated that they resorted to drugs as a temporary means to cope with financial instability, job loss, and unmet educational aspirations (Henkel, Reference Henkel2011; Khan, Reference Khan2011; Frasquilho et al., Reference Frasquilho, Matos, Salonna, Guerreiro, Storti, Gaspar and Caldas-de-Almeida2015). These events exemplify a theoretical framework that suggests individuals might resort to antisocial behaviors as a coping mechanism for the disappointment experienced when their aspirations and dreams are unfulfilled (Henkel, Reference Henkel2011; Frasquilho et al., Reference Frasquilho, Matos, Salonna, Guerreiro, Storti, Gaspar and Caldas-de-Almeida2015). This viewpoint aligns with stress theory (Agnew, Reference Agnew1992), which posits that economically disadvantaged cultures tend to depend more on maladaptive behaviors such as substance use due to a deficiency in effective coping strategies (Lazarus and Folkman, Reference Lazarus and Folkman1986). In Khyber Pakhtunkhwa, young women encounter significant economic challenges and gender-related barriers to both education and employment. As a result, some may resort to drug use as a means of coping or seeking empowerment.

Familial relationships, in addition to these features, significantly shape the emergence of susceptibility. Attachment theory, as proposed by Bowlby (Reference Bowlby1979), emphasizes the significance of early emotional bonds in shaping future behaviors. Research suggests that young individuals are more likely to use drugs due to parental substance use and dysfunctional interactions between parents and children (Farrell and White, Reference Farrell and White1998). The dual-process theory of decision-making (Evans and Stanovich, Reference Evans and Stanovich2013) provides an understanding of the participants’ impulsivity. Giedd (Reference Giedd2015) notes that the immature prefrontal cortex in youngsters increases their propensity for risky behaviors, such as experimenting with drugs. When considered collectively, these concepts illustrate the multitude of factors that interplay, particularly the social, relational and developmental contexts of young girls and young women, which collectively shape drug use behaviors.

The investigation emphasizes the value of thorough and culturally aware strategies that address multiple facets of susceptibility. Programs should incorporate education that emphasizes peer interaction, provide mental health resources, promote economic empowerment efforts and create nurturing family settings to enhance communication and build resilience. Interventions must be customized to fit the cultural landscape of Khyber Pakhtunkhwa, where distinct challenges stem from patriarchal norms and limitations on women’s mobility. By tackling social, psychological and economic stressors at the same time, prevention and treatment initiatives can more effectively assist young women, diminish dependence on substances as coping strategies and foster healthier, more resilient communities.

Implications for research: This study fills a significant knowledge gap and contributes to the growing body of qualitative research on women’s drug use in conservative countries. Larger multisite studies across Pakistan are needed to examine regional differences, as the limited sample size of this study limits the generalizability of its findings. Longitudinal studies need to explore the impact of social pressures, mental illness and financial instability on drug use and recovery. Comparative studies in South Asia can shed light on cultural norms, gender expectations and socioeconomic constraints. It is critical to include the perspectives of communities, families and service providers in future research.

Implications for policy: The findings emphasize the necessity for drug policies that consider gender in Khyber Pakhtunkhwa, underscoring the susceptibility of young women. The investigation suggests ways to enhance mental health frameworks, promote women’s economic empowerment via education, training and job initiatives, and integrate substance use prevention into youth educational curricula, while pointing out the importance of culturally attuned policies and community involvement.

Implications for practice: The research suggests a multidisciplinary approach for drug use therapy, involving mental health counseling, peer support networks, safe spaces for young women and job counseling and financial literacy training. Collaboration between NGOs, schools, healthcare professionals and local communities is crucial for prevention, treatment and long-term recovery to work.

Conclusion

This study examines factors influencing substance use among young women in Khyber Pakhtunkhwa, Pakistan. The study finds that social influences, psychological stress and economic hardship play a critical role in substance use, which often leads to relapse. The findings suggest that substance use among young women in conservative settings occurs as a response to systemic and interpersonal challenges. The study emphasizes the importance of analyzing substance use from cultural, social and economic perspectives, while also addressing differences in contemporary beliefs about drug addiction among genders. An emphasis on peer-focused prevention, increased access to mental health services and initiatives to promote financial independence can achieve successful drug addiction treatment.

Open peer review

To view the open peer review materials for this article, please visit http://doi.org/10.1017/gmh.2025.10071.

Data availability statement

The study’s data are unavailable to the public or inaccessible upon request, as this information could compromise the privacy of the research participants.

Author contribution

Muhammad Suhail Khan: Conceptualized the study and developed the methodology, conducting a literature review while creating the original draft, performing data analysis and drafting the manuscript. Yao Dewei and Wu Zongyou: Supervised the project. Aman Khan, Ibrahim, and Anastasiia Pavlova: Conducted interviews and contributed to interpreting the results and providing critical revisions.

Financial support

This research received no specific grant from any funding agency, commercial or not-for-profit sectors.

Competing interests

The authors declare none.

Ethics standard

The project was approved by the Ethics Committee of the School of Sociology and Political Science of Anhui University on May 20, 2021. Interviewed participants provided written informed consent with their signatures.

References

Agnew, R (1992) Foundation for a general strain theory of crime and delinquency. Criminology 30(1), 4788.Google Scholar
Ahmed, T, Wassan, R, Qadri, NA and Ahmed, S (2022) Prevalence and determinants of drugs abuse among youth in Hyderabad, Sindh, Pakistan. Journal of Management Practices, Humanities and Social Sciences 6(5), 19.Google Scholar
Ali, DF (1999, October) Drug Abuse in the North-West Frontier Province of Pakistan And its Impact on the National Health System. University of Toronto.Google Scholar
Atif, M, Malik, I, Asif, M, Qamar-Uz-Zaman, M, Ahmad, N and Scahill, S (2020) Drug safety in Pakistan. In Drug Safety in Developing Countries. San Diego, CA: Academic Press, pp. 287325.Google Scholar
Bandura, A and Walters, RH (1977) Social Learning Theory, Vol. 1. Englewood Cliffs, NJ: Prentice hall, pp. 141154.Google Scholar
Bowlby, J (1979) The Bowlby-Ainsworth attachment theory. Behavioral and Brain Sciences 2(4), 637638.Google Scholar
Carpenter, M (2015) Caffeinated: How our Daily Habit Helps, Hurts, and Hooks Us. New York, NY: Penguin.Google Scholar
Catalano, RF, Fagan, AA, Gavin, LE, Greenberg, MT, Irwin, CE, Ross, DA and Shek, DT (2012) Worldwide application of prevention science in adolescent health. The Lancet 379(9826), 16531664.Google Scholar
Cohen, N and Arieli, T (2011) Field research in conflict environments: Methodological challenges and snowball sampling. Journal of Peace Research 48(4), 423435.Google Scholar
Dawn News (2015) Around 7 million drug addicts in Pakistan, Senate told -Pakistan Dawn News. Available at https://www.dawn.com/news/1192715.Google Scholar
Dusek, G, Yurova, Y and Ruppel, CP (2015) Using social media and targeted snowball sampling to survey a hard-to-reach population: A case study. International Journal of Doctoral Studies 10, 279.Google Scholar
Evans, JS and Stanovich, KE (2013) Dual-process theories of higher cognition: Advancing the debate. Perspectives on Psychological Science 8(3), 223241.Google Scholar
Farooq, SA, Rasooly, MH, Abidi, SH, Modjarrad, K and Ali, S (2017) Opium trade and the spread of HIV in the Golden crescent. Harm Reduction Journal 14(1), 47.Google Scholar
Farrell, AD and White, KS (1998) Peer influences and drug use among urban adolescents: Family structure and parent–adolescent relationship as protective factors. Journal of Consulting and Clinical Psychology 66(2), 248.Google Scholar
Farrington, CA, Roderick, M, Allensworth, E, Nagaoka, J, Keyes, TS, Johnson, DW and Beechum, NO (2012) Teaching Adolescents to Become Learners: The Role of Noncognitive Factors in Shaping School Performance–A Critical Literature Review. Chicago, IL: Consortium on Chicago School Research.Google Scholar
Frasquilho, D, Matos, MG, Salonna, F, Guerreiro, D, Storti, CC, Gaspar, T and Caldas-de-Almeida, JM (2015) Mental health outcomes in times of economic recession: a systematic literature review. BMC Public Health 16(1), 115.Google Scholar
Ghate, D and Hazel, N (2002) Parenting in Poor Environments: Stress, Support and Coping. London: Jessica Kingsley Publishers.Google Scholar
Giedd, JN (2015) The amazing teen brain. Scientific American 312(6), 3237.Google Scholar
Goldberg, R (2012) Addictive Behaviour in Children and Young Adults: The Struggle for Freedom. Edinburgh: Floris Books.Google Scholar
Hawkins, JD, Catalano, RF and Miller, JY (1992) Risk and protective factors for alcohol and other drug problems in adolescence and early adulthood: Implications for substance abuse prevention. Psychological Bulletin 112(1), 64.Google Scholar
Henkel, D (2011) Unemployment and substance use: A review of the literature (1990–2010). Current Drug Abuse Reviews 4(1), 427.Google Scholar
Henneberger, AK, Mushonga, DR and Preston, AM (2021) Peer influence and adolescent substance use: A systematic review of dynamic social network research. Adolescent Research Review 6(1), 5773.Google Scholar
Hogg, MA (2016) Social identity theory. In Understanding Peace and Conflict through Social Identity Theory: Contemporary Global Perspectives. Cham: Springer International Publishing, pp. 317.Google Scholar
Kaminer, Y, Bukstein, OG and Bukstein, OG (eds.) (2011) Adolescent Substance Abuse: Psychiatric Comorbidity and High Risk Behaviors. New York, NY: Routledge.Google Scholar
Kandel, DB, Kessler, RC and Margulies, RZ (1978) Antecedents of adolescent initiation into stages of drug use: A developmental analysis. Journal of Youth and Adolescence 7(1), 1340.Google Scholar
Khan, A, Ding, BR, Khan, MS and Épiphanie, EN (2025) Exploring the intersection of tradition and modernity: Parents’ perspectives on co-education in Khyber Pakhtunkhwa, Pakistan. African Journal of Reproductive Health 29(7), 94106.Google Scholar
Khan, MS (2011) Poverty of Opportunity for Women Selling Sex in Lahore, Pakistan: Knowledge, Experiences and Magnitude of HIV and STIs. Sweden: Karolinska Institutet.Google Scholar
Khan, MS, Zongyou, W, Dewei, Y, Khan, A and Pavlova, A (2024) Gender, culture, and migration: A qualitative study of the socioeconomic challenges facing afghan women refugees in Khyber Pakhtunkhwa, Pakistan. African Journal of Reproductive Health 28(5), 90102.Google Scholar
Khan, NA, Naz, AR, Hu, R and Hussain, ZA (2017) Benzodiazepine abuse: A survey study of the causes and consequences of benzodiazepine abuse among young people in DIR LOWER, KPK, Pakistan. Journal of Disease and Global Health 10, 7481.Google Scholar
Khantzian, EJ (1987) The self-medication hypothesis of addictive disorders: Focus on heroin and cocaine dependence. Cocaine Crisis, 6574. https://doi.org/10.1007/978-1-4613-1837-8_7Google Scholar
Khantzian, EJ and Albanese, MJ (2008) Understanding Addiction as Self Medication: Finding Hope behind the Pain. Lanham, MD: Rowman & Littlefield Publishers.Google Scholar
Kilpatrick, DG, Acierno, R, Saunders, B, Resnick, HS, Best, CL and Schnurr, PP (2000) Risk factors for adolescent substance abuse and dependence: data from a national sample. Journal of Consulting and Clinical Psychology 68(1), 19.Google Scholar
Lanini, S, Easterbrook, PJ, Zumla, A and Ippolito, G (2016) Hepatitis C: global epidemiology and strategies for control. Clinical Microbiology and Infection 22(10), 833838.Google Scholar
Lazarus, RS and Folkman, S (1986) Cognitive theories of stress and the issue of circularity. In Dynamics of Stress: Physiological, Psychological and Social Perspectives. Boston, MA: Springer US, pp. 6380.Google Scholar
Lemahieu, JL and Me, A (2014) World Drug Report. Vienna: UNODC.Google Scholar
Malik, A and Sarfaraz, SF (2011) Origin and development of drug addiction in South Asia with special reference to Pakistan. Pakistan Journal of Commerce and Social Sciences (PJCSS) 5(1), 155165.Google Scholar
Marshall, BD and Werb, D (2010) Health outcomes associated with methamphetamine use among young people: A systematic review. Addiction 105(6), 9911002.Google Scholar
Masood, S and Us Sahar, N (2014) An exploratory research on the role of family in youth’s drug addiction. Health Psychology and Behavioral Medicine: An Open Access Journal 2(1), 820832.Google Scholar
Merton, RK (1968) Social Theory and Social Structure. New York, NY: Simon and Schuster.Google Scholar
Morvan, C and O’Connor, A (2017) An Analysis of Leon Festinger’s a Theory of Cognitive Dissonance. London: Macat Library.Google Scholar
Perry, JL and Carroll, ME (2008) The role of impulsive behavior in drug abuse. Psychopharmacology 200(1), 126.Google Scholar
Piña, JA, Namba, MD, Leyrer-Jackson, JM, Cabrera-Brown, G and Gipson, CD (2018) Social influences on nicotine-related behaviors. International Review of Neurobiology 140, 132.Google Scholar
Preston, JD, O’Neal, JH, Talaga, MC and Moore, BA (2021) Child and Adolescent Clinical Psychopharmacology Made Simple. Oakland, CA: New Harbinger Publications.Google Scholar
Prinstein, MJ, Boergers, J and Spirito, A (2001) Adolescents’ and their friends’ health-risk behavior: Factors that alter or add to peer influence. Journal of Pediatric Psychology 26(5), 287298.Google Scholar
Rose, ME and Cherpitel, CJ (2011) Alcohol: Its History, Pharmacology, and Treatment. Center City, MN: Hazelden Publishing.Google Scholar
Scheibe, A, Young, K, Versfeld, A, Spearman, CW, Sonderup, MW, Prabdial-Sing, N, Puren, A and Hausler, H (2020) Hepatitis B, hepatitis C and HIV prevalence and related sexual and substance use risk practices among key populations who access HIV prevention, treatment and related services in South Africa: Findings from a seven-city cross-sectional survey (2017). BMC Infectious Diseases 20(1), 655.Google Scholar
Seaward, BL (2017) Managing Stress. Burlington, MA: Jones & Bartlett Learning.Google Scholar
Sinha, R (2001) How does stress increase risk of drug abuse and relapse? Psychopharmacology 158(4), 343359.Google Scholar
Smith, GT and Cyders, MA (2016) Integrating affect and impulsivity: The role of positive and negative urgency in substance use risk. Drug and Alcohol Dependence 163, S3S12.Google Scholar
Steinberg, L, Fletcher, A and Darling, N (1994) Parental monitoring and peer influences on adolescent substance use. Pediatrics 93(6), 10601064.Google Scholar
Sun, AP (2007) Relapse among substance-abusing women: Components and processes. Substance Use & Misuse 42(1), 121.Google Scholar
van Solinge, TB (2007) Drugs and money: Managing the drug trade and crime-money in Europe. Oxford University Press.Google Scholar
Verma, AS, Kumar, V, Saha, MK, Dutta, S and Singh, A (2020) HIV: Biology to treatment. In NanoBioMedicine. Singapore: Springer Singapore, pp. 167197.Google Scholar
Ward, C and Byrd, WA (2004) Afghanistan’s Opium Drug Economy. Washington, DC: World Bank.Google Scholar
Wills, TA (1990) Stress and coping factors in the epidemiology of substance use. In Research Advances in Alcohol and Drug Problems: Volume 10. Boston, MA: Springer US, pp. 215250.Google Scholar
Wills, TA (2013) Stress and coping in early adolescence: Relationships to substance use in urban school samples. In Child Health Psychology. New York, NY: Psychology Press, pp. 95121.Google Scholar
Wolfe, DA, Jaffe, PG and Crooks, CV (2008) Adolescent Risk Behaviors: Why Teens Experiment and Strategies to Keep them Safe. New Haven, CT: Yale University Press.Google Scholar
World Health Organization (2004) Neuroscience of Psychoactive Substance Use and Dependence. World Health Organization.Google Scholar
World Health Organization (2018) Global Status Report on Alcohol and Health 2018. World Health Organization.Google Scholar
Zada, B, Shah, M, Saleem, A, Ashraf, R, Hameed, A and Yousaf, A (2022) Quality of life among substance use disorder patients in Khyber Pakhtunkhwa, Pakistan. Pakistan Journal of Medical & Health Sciences 16(03), 843843.Google Scholar
Zubair, Z (2015) Measuring the socio-economic costs of drug addiction in rehabilitation centers of Lahore. Doctoral dissertation.Google Scholar
Figure 0

Table 1. Demographic and drug use status of participants

Figure 1

Table 2. Types of substances used by participants (N = 12)

Author comment: Drug use among young women in Pakistan: A qualitative study of socioeconomic and psychological perspectives — R0/PR1

Comments

Muhammad Suhail Khan

Anhui University

No: 111 Jiulong Road, Jingkai District, Hefei city, Anhui Province: 230601, P.R. China

Email: sohail.khattak1@yahoo.com or mskhansocio@stu.ahu.edu.cn

17/09/2024

Editor-in-Chief

CAMBRIDGE PRISMS-GLOBAL MENTAL HEALTH

Dear Editor,

I am pleased to submit my manuscript titled, “Drug Abuse Among Adolescent Girls: A Qualitative Study of Socio-Economic and Psychological Perspectives,” for consideration in CAMBRIDGE PRISMS-GLOBAL MENTAL HEALTH. I believe this manuscript aligns well with the scope of CAMBRIDGE PRISMS-GLOBAL MENTAL HEALTH, given its focus on psychological, behavioral, and social determinants of health. I hope that this contribution will offer valuable insights to researchers and practitioners concerned with adolescent mental health and social issues.

Thank you for considering my submission. I look forward to your feedback.

Sincerely,

Muhammad Suhail Khan

Ph.D. scholar

Department of Sociology,

School of Sociology and Political Science,

Anhui University

Review: Drug use among young women in Pakistan: A qualitative study of socioeconomic and psychological perspectives — R0/PR2

Conflict of interest statement

‘None’

Comments

The study titled “Drug abuse among adolescent girls: a qualitative study of socio-economic and psychological perspectives” provides important insights into the issue of drug addiction among young girls in Khyber Pakhtunkhwa, Pakistan. The research employs comprehensive interviews and theoretical frameworks such as social identity theory and the self-medication hypothesis to provide context for the findings.

Nevertheless, the sample size of 12 participants may allow for more applicability of the findings. The paper would be enhanced by incorporating more recent studies on adolescent drug use, especially those that concentrate on the South Asian region or provide comparative analyses with other developing countries. An in-depth exploration of societal norms and gender dynamics in the area may yield valuable insights. The paper may also propose more comprehensive, evidence-driven intervention strategies, including mental health services, peer support, and economic empowerment programs.

Review: Drug use among young women in Pakistan: A qualitative study of socioeconomic and psychological perspectives — R0/PR3

Conflict of interest statement

Reviewer declares none.

Comments

Dear Author,

Drug abuse in Pakistan is a very serious issue. Educated and even the educated youth are trapped in this menace. I have thoroughly checked your article. I have found some mistakes which if incorporated will shine your research work. Following are a few suggestions;

Revisit your reference, Journal name and issue numbers are missing.

Your methodology is not clear please elaborate on it further

Replace the word “data was‘ with ’data were”

Thanks

Review: Drug use among young women in Pakistan: A qualitative study of socioeconomic and psychological perspectives — R0/PR4

Conflict of interest statement

Reviewer declares none.

Comments

This paper presents qualitative findings from in-depth interviews with adolescent girls (i.e., women aged 18 to 21) in Khyber Pakhtunkhwa, Pakistan, focused on investigating socioeconomic and psychological factors that influence drug use. It is clear that the authors thoroughly researched theories surrounding substance use in young adults, and that much thought went into the design and execution of this study. While the themes identified in the interviews themselves are not unique (i.e., using substances to fit in with peers, substance use as a coping mechanism), this study is among the first to assess reasons for substance use among young women in Pakistan. Given the high burden of substance use in Pakistan, and the lack of research on substance use among women in this country, findings from the present study do start to fill a gap in the literature.

<p>Despite this, I have some major concerns with how the manuscript is written, and how the study was conducted, which I have outlined below. I strongly recommend that the authors address the following comments before the manuscript is reconsidered for publication.

<p>

<p><b>Major Comments:</b>

<p>1. This journal requires that research involving human participants be approved by appropriate institutional ethics committee(s) and conform to relevant international ethical and legal standards for research. While the authors state that “informed consent was obtained” and “confidentiality was strictly maintained,” they do not mention obtaining approval from an ethics board. I strongly suggest that the authors include the name of ethics board(s) and protocol number(s) in the Ethics Statement. I also recommend that the authors add a statement about receiving ethics approval in the main body of the text. If this research was not approved by an ethics board, this should also be clearly stated, along with justification for why an ethics board was not used.

<p>

<p>2. The authors spend over thirteen pages (more than half of the manuscript) providing the reader with background information on substance use in Pakistan, substance use among adolescents, and negative effects of substance use. While this information is interesting, I do not believe this level of detail is needed to understand the study. In fact, I personally found that this level of detail distracted from the actual study. In contrast, I think the manuscript would be strengthened if more detail were added to the Methods section (detailed below). Further, more information should be added to the Discussion section, which is currently a single paragraph. Finally, given that the manuscript is over 3000 words over the research article word limit of 5000 words, I recommend that the authors make the following changes to text’s structure:

<p>a. The Introduction should be significantly shortened, focusing on just the background details most pertinent to the current study. To ensure they are getting their main points across, I also recommend that the researchers summarize existing research, rather than detailing it. Likewise, I recommend removing the two maps included in the Introduction (while interesting, they are both over a decade old, and do not directly relate to the present study). Finally, the authors may choose to move some of the information on theories of adolescent drug use to the Discussion section, where they can more clearly integrate their findings into the existing literature.

<p>b. I recommend that the authors add the following information to the Methods section:

<br>i. Eligibility criteria for participants

<br>ii. How/why a sample size of 12 participants was chosen

<br>iii. How initial participants were identified. While the authors say they were “identified with the help of healthcare providers and social workers,” it is unclear to me how the researchers contacted these healthcare providers/social workers. Did the researchers already have relationships with certain healthcare facilities? If so, which types of facilities? How were these facilities chosen?

<br>iv. Information on the “female colleagues” who conducted the interviews – were these research assistants, professors, etc.? Were they bilingual, or did they only speak Pashto? Did they have previous experience conducting similar interviews?

<br>v. Processes for developing interview guides

<br>vi. Whether patients were compensated for interviews (and if so, how much)

<br>vii. Substances used by participants

<br>viii. How long the two participants had stopped using substances, and which types of substances

<br>ix. Further define the “recovery treatment program” that four participants were attending

<br>x. How many participants were interviewed in Mardan vs. Peshawar

<br>xi. How the participant sample compares to the overall population – for instance, is the level of education typical for women in Pakistan or atypical? In general, were participants of high, middle, or low socioeconomic status?

<br>xii. How were interviews transcribed / who transcribed them?

<br>xiii. What steps were taken to ensure confidentiality – for instance, were transcripts deidentified with study IDs? Where was data stored?

<br>xiv. Who was involved in the coding process? How many coders coded each transcript? How were discrepancies between coders resolved?

<p>c. The authors should expand on the Discussion section to better contextualize their findings within the existing literature and discuss strengths and limitations of the study. The authors may also want to comment on the rationale for separating the themes of “mental health issues,” and “financial difficulties or unemployment,” as both themes seem to point to using substances to cope with difficulties.

<p>

<p>3. The objectives of this study were to explore factors influencing drug use among adolescent girls in Pakistan. Yet, the study only enrolled young adults aged 18 or older. The World Health Organization currently defines adolescence as 10 to 19 years of age. Given the discrepancy between this definition and the age of participants, I suggest that the authors either (a) consider describing their population as “young women” instead of adolescent girls or (b) provide rationale as to why women aged 18 – 21 are considered adolescents in Pakistan.

<p>

<p>4. The authors use language like “drug abuse” and “drug users” throughout the manuscript. Recently, many researchers and institutions in the US and other countries have started moving away from this language due to its potentially stigmatizing nature. I recommend substituting “drug abuse” with “drug use,” and using person-first language when referring to people who use drugs. When considering language, the authors may find the following resources helpful:

<br>https://nida.nih.gov/nidamed-medical-health-professionals/health-professions-education/words-matter-terms-to-use-avoid-when-talking-about-addiction

<br>https://www.canada.ca/en/health-canada/services/publications/healthy-living/stigma-why-words-matter-fact-sheet.html

<br>https://www.recoveryanswers.org/addiction-ary/

<p>

<p>

<b>Minor Comments:</b>

<p>5. I recommend that the authors double check the formatting of this manuscript against this journal’s guidelines. I believe this manuscript is currently over the world limit and may not be using the recommended citation style. Additionally, the authors should include the Impact Statement above the Introduction, rather than within the Introduction, as this was initially unclear.

<p>6. The authors state that details of the research funding are currently restricted by supervisors. I recommend the authors double check with the editor to ensure that the journal allows this restriction of information.

<p>7. The authors state that “cultural norms and traditions, along with the segregated nature of the study region, have rendered the data supporting the study’s findings unavailable.” Based on this statement alone, it is unclear to me how norms/traditions/ the segregated nature of the study region precludes de-identified transcripts or a codebook from being made available upon request. The authors may want to elaborate upon this in the Methods section.

Recommendation: Drug use among young women in Pakistan: A qualitative study of socioeconomic and psychological perspectives — R0/PR5

Comments

Thank you for submitting your manuscript to our journal. We feel your manuscript provides an important addition to the literature, but some major revisions are required as indicated by the third reviewer. Please also consider adding reference to Pakistan in your title as this study was specific to this population. We look forward to receiving a revised manuscript.

Decision: Drug use among young women in Pakistan: A qualitative study of socioeconomic and psychological perspectives — R0/PR6

Comments

No accompanying comment.

Author comment: Drug use among young women in Pakistan: A qualitative study of socioeconomic and psychological perspectives — R1/PR7

Comments

No accompanying comment.

Review: Drug use among young women in Pakistan: A qualitative study of socioeconomic and psychological perspectives — R1/PR8

Conflict of interest statement

Reviewer declares none.

Comments

This paper presents qualitative findings from in-depth interviews with adolescent girls (i.e., women aged 18 to 21) in Khyber Pakhtunkhwa, Pakistan, focused on investigating socioeconomic and psychological factors that influence drug use. The authors were responsive to most of the feedback in the first round of reviews, resulting in a much stronger manuscript. While the majority of comments were addressed, not all comments were addressed, and I still have some lingering questions/suggestions for the authors. I suggest that these comments are addressed before the manuscript is accepted for publication.

1. Eligibility Criteria: The authors added much more information to the eligibility criteria, thus strengthening the methods section. However, I still have some clarifying questions:

1a. Eligibility criteria included that participants “demonstrate a readiness to share their experiences.” How was this measured? Were specific questions asked during a screening process, or was interest in the study considered to demonstrate readiness?

1b. Eligibility criteria included that participants “maintain mental and physical stability to ensure they can engage in an interview without experiencing immediate distress.” How was this measured? Or, were there specific criteria around when and how participants were to be excluded (for instance, if they displayed certain symptoms during the interviews)?

1c. The sentence “individuals residing in Khyber Pakhtunkhwa, particularly in Mardan and Peshawar, must give informed consent” makes it sound like only participants in these two locations had to give informed consent. I think this sentence would be clearer if you rephrased it to say something like “participants had to reside in Mardan or Peshawar, and all participants had to give informed consent prior to beginning the study.”

2. Sample Size: The authors state that “based on data saturation, we decided on a sample size of 12 people…”. Does this mean that themes were assessed on an ongoing basis and recruitment stopped once saturation was reached? Or that 12 was the anticipated number of participants needed to reach theoretical saturation (if so, please cite previous research suggesting 12 participants may be sufficient)? Or were only 12 people available because this is a hard-to-reach population? The authors should clarify (1) whether recruiting 12 people was the initial plan or not; (2) whether theoretical saturation was assessed on an ongoing basis or not; and (3) if assessed on an ongoing basis, if this included just primary pre-determined themes, or secondary themes as well.

3. In my previous review, I wrote “The authors may also want to comment on the rationale for separating the themes of “mental health issues” and “financial difficulties or unemployment,” as both themes seem to point to using substances to cope with difficulties.” While the authors now do talk about mental health and financial difficulties as two separate factors contributing to drug use in the discussion section, they do not directly discuss why they chose to consider these two different themes. Please clarify why you chose to separate these two themes, although they are both themes about coping. The discussion section would be an appropriate place to comment upon this.

4. (Not addressed from previous review): In my previous review, I wrote:

“The objectives of this study were to explore factors influencing drug use among adolescent girls in Pakistan. Yet, the study only enrolled young adults aged 18 or older. The World Health Organization currently defines adolescence as 10 to 19 years of age. Given the discrepancy between this definition and the age of participants, I suggest that the authors either (a) consider describing their population as “young women” instead of adolescent girls or (b) provide rationale as to why women aged 18 – 21 are considered adolescents in Pakistan.”

This comment was not addressed in the previous response to reviewers. Kindly address this comment.

5. Regarding potentially stigmatizing language, the authors were responsive and changed the term “drug abuse” to “drug use” throughout the manuscript. However, while the authors state in their response that they changed “drug users” to “people who use drugs,” I could not find any evidence of this in the manuscript. I recommend that the authors change “drug users” to person-first language throughout the manuscript.

6. The authors were very responsive to cutting text. However, I believe the manuscript is still ~500 words over the journal’s word limit. While I do not personally have a problem with the longer manuscript (and default to the editor’s opinion on this manner), I think there are many places in the introduction where the authors could significantly shorten their text. Specifically, I recommend that the authors:

6a. Summarize versus list data: For instance, in the first paragraph, the authors may consider removing specific statistics on who uses drugs worldwide and drug types, and instead say something like “drug use increases the risk of HIV, hepatitis C, and other health complications, thus increasing its public health significance.” Likewise, in paragraph 2, the authors could just say “commonly used substances in Pakistan include…” rather than using specific statistics. Changes like this can be made throughout the introduction.

6b. Turn the section titled “Factors contributing to adolescent substance use” into just one or two paragraphs: There is a lot of information on various factors that may contribute to adolescent substance use. While this is interesting, I do not think this level of information is needed. I think it is sufficient to say something like “In other populations, factors like socioeconomic status, family dynamics, peer influence, mental health, and cognitive development have been shown to contribute to adolescent substance use. For instance…”. The authors can also move some of this detail to their discussion (as the discussion of findings is still very brief).

Minor Comments:

7. The authors did a good job providing more information on the people who conducted the interviews. I recommend clarifying that they were research assistants, rather than just calling them “skilled assistants.”

8. The authors did a good job providing information on the types of substances that were used by participants. I recommend adding this information to the table (e.g., Opioids = N, Methamphetamine = N, Cannabis = M, etc.)

Recommendation: Drug use among young women in Pakistan: A qualitative study of socioeconomic and psychological perspectives — R1/PR9

Comments

Thank you for the revisions to your manuscript which, as stated by the reviewer, have greatly strengthened your manuscript. Please note, however, that some additional minor revisions are required before the manuscript can be published. We appreciate your continued efforts and look forward to receiving your revised draft.

Decision: Drug use among young women in Pakistan: A qualitative study of socioeconomic and psychological perspectives — R1/PR10

Comments

No accompanying comment.

Author comment: Drug use among young women in Pakistan: A qualitative study of socioeconomic and psychological perspectives — R2/PR11

Comments

No accompanying comment.

Review: Drug use among young women in Pakistan: A qualitative study of socioeconomic and psychological perspectives — R2/PR12

Conflict of interest statement

Reviewer declares none.

Comments

This paper presents qualitative findings from in-depth interviews with women aged 18 to 21 in Khyber Pakhtunkhwa, Pakistan, focused on investigating socioeconomic and psychological factors that influence drug use. This is my third time reviewing this manuscript. The authors were very responsive to feedback and adequately addressed all previously stated concerns.

While I do not have concerns with the science, and believe this manuscript is relevant for this journal, I still have some concerns with the clarity of the writing and organization of the paper (detailed below). It is possible that these concerns are based on my own stylistic preferences/ that the journal does not share these views. Therefore, I defer to the editor on whether these concerns should be addressed before publication, or whether the manuscript is suitable for publication as it is currently written.

While I am formally recommending a minor revision to convey my concerns with the clarity of the writing, based on the science alone, I do recommend this manuscript for publication.

Clarity of writing:

- I personally believe that the introduction would be strengthened if the authors shortened it and made it more focused. Some specific suggestions are:

o Combine paragraphs 1 & 2, or make paragraph 1 focused on substance use in general and paragraph 2 focused on substance use specifically in Pakistan. I found going back and forth between the world and Pakistan somewhat confusing.

o Consider removing mention of substances like caffeine, unless there is a reason the authors want to focus on caffeine (and if so, this should be clarified).

o Ensure each paragraph in the introduction has a distinct and meaningful message. Right now, the paragraphs somewhat read like a list of facts. I think it would be much more clear to the reader if you summarized the takeaways of most of these facts, rather than stating them.

- Throughout the manuscript, there were times I felt like sentences were written awkwardly and I had difficulty fully grasping what the authors were trying to convey. For example (please note this is not an exhaustive list):

o Introduction: “The majority use heroin, with 29.5% developing cannabis addiction (Ali, 1999) - To me, this reads as if the authors are suggesting that people develop a cannabis addiction because they use heroin. I recommend rephrasing this sentence or removing it all together (as I am not sure what it adds to the introduction, and it is likely outdated).

o Objective: “How does the social factor influence young women’s drug use?” - I recommend rephrasing this as “how do social factors influence…” because right now it sounds like there is only one social factor.

o Research Design: “We collected the data using snowball sampling from 12 in-depth qualitative interviews…” - This reads as the sampling came from 12 interviews, rather than recruiting the 12 people for interviews via snowball sampling. I recommend placing a period after “snowball sampling” and making this two separate sentences.

o Sampling: “The study’s eligibility criteria stipulated that participants, including young women aged 18 to 21, must meet specific conditions.” - This sounds like there were also participants who were not 18 to 21. I recommend rephrasing this to say something like “Eligibility criteria included: (1) identifying as a woman; (2) aged 18 – 21; (3) possess a background of drug use…, etc.”

o Strengths and limitations: “However, the limited sample size may not fully capture the experiences of marginalized or less visible users. The results provide significant results.” - I would elaborate on how the study provides significant results, as it is confusing to have this conclusion immediately following a limitation.

Manuscript Organization:

- I do not think you need to put “Source: Authors’ analysis” under your tables. As you are presenting data from the study described in this manuscript, it is assumed that it comes from your analysis of this data.

- The Findings section seems to be a combination of a traditional results and discussion section, as the authors discuss findings as they present them. Given that there is a separate discussion section, I found this a little confusing. However, I ultimately defer to the journal on if they are okay with this manuscript organization.

Recommendation: Drug use among young women in Pakistan: A qualitative study of socioeconomic and psychological perspectives — R2/PR13

Comments

This manuscript has been greatly improved upon during the revision process and we look forward to publishing it in our journal. At this stage, we feel that the manuscript requires some slight improvements in the clarity of the writing prior to publication. The reviewer has provided some very good examples of ways to improve the clarity. We recommend that the authors edit the manuscript accordingly and do a thorough read through and polish to make it ready for publication. We look forward to receiving your revised draft.

Decision: Drug use among young women in Pakistan: A qualitative study of socioeconomic and psychological perspectives — R2/PR14

Comments

No accompanying comment.

Author comment: Drug use among young women in Pakistan: A qualitative study of socioeconomic and psychological perspectives — R3/PR15

Comments

No accompanying comment.

Review: Drug use among young women in Pakistan: A qualitative study of socioeconomic and psychological perspectives — R3/PR16

Conflict of interest statement

Reviewer declares none.

Comments

The authors thoroughly addressed all previous concerns. Procedures and findings are presented clearly and well-integrated into the existing literature in the discussion. I recommend this manuscript for publication.

Recommendation: Drug use among young women in Pakistan: A qualitative study of socioeconomic and psychological perspectives — R3/PR17

Comments

We are grateful for your ongoing revisions and commitment to publishing in this journal. Your manuscript has been greatly improved upon and we feel it is ready for publication. One final note is that some of the sentences appear to be highlighted in turquoise, but this will hopefully be addressed in the publication process. Thank you again for your dedication and hard work.

Decision: Drug use among young women in Pakistan: A qualitative study of socioeconomic and psychological perspectives — R3/PR18

Comments

No accompanying comment.