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Effect of antioxidants on preimplantation embryo development in vitro: a review

Published online by Cambridge University Press:  14 January 2021

Sam Zarbakhsh Open the ORCID record for Sam Zarbakhsh [Opens in a new window]
Sam Zarbakhsh*
Affiliation:
1Nervous System Stem Cells Research Center, Semnan University of Medical Sciences, Semnan, Iran 2Department of Anatomy, Faculty of Medicine, Semnan University of Medical Sciences, Semnan, Iran
*
Author for correspondence: Sam Zarbakhsh. Nervous System Stem Cells Research Center, Semnan University of Medical Sciences, Semnan, Iran. E-mail: smzarbakhsh@gmail.com
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Summary

In vitro culture of the embryo is a useful method to treat infertility that shows embryo potential for selecting the best one to transfer and successfully implantation. However, embryo development in vitro is affected by oxidative stresses such as reactive oxygen species that may damage embryo development. Antioxidants are molecules found in fruits, vegetables, and fish that play an important role in reducing oxidative processes. In the natural environment, there is a physiological antioxidant system that protects embryos against oxidative damage. This antioxidant system does not exist in vitro. Antioxidants act as free radical scavengers and protect cells or repair damage done by free radicals. Various studies have shown that adding antioxidants into embryo culture medium improves embryo development in vitro. This review article emphasizes different aspects of various antioxidants, including types, functions and mechanisms, on the growth improvement of different species of embryos in vitro.

Keywords

AntioxidantsEmbryo developmentIn vitroOxidative stress
Type
Review Article
Information
Zygote , Volume 29 , Issue 3 , June 2021 , pp. 179 - 193
Copyright
© The Author(s), 2021. Published by Cambridge University Press

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