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The use of chicoric acid from Echinacea purpurea as a feed additive in poultry nutrition

Published online by Cambridge University Press:  08 December 2017

M. SAEED ,
D. BABAZADEH ,
M.A. ARAIN Open the ORCID record for M.A. ARAIN [Opens in a new window] ,
M. NAVEED ,
Q.A. SHAH ,
A.A. KAMBOH ,
A. MOSHAVERI ,
F. MODARRESI-GHAZANI ,
V. HEJAZI  and
S. CHAO
M. SAEED
Affiliation:
Department of Animal Nutrition, College of Animal Sciences and Technology, Northwest A&F University, Yangling, China, 712100
D. BABAZADEH
Affiliation:
Young Researchers and Elite Club, Tabriz Branch, Islamic Azad University, Tabriz, Iran
M.A. ARAIN
Affiliation:
Department of Animal Nutrition, College of Animal Sciences and Technology, Northwest A&F University, Yangling, China, 712100 Faculty of Veterinary and Animal Sciences, Lasbela University of Agriculture, Water and Marine Sciences, 3800, Uthal, Balochistan, Pakistan
M. NAVEED
Affiliation:
Department of Clinical Pharmacy, School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing, Jiangsu Province, 211198, China
Q.A. SHAH
Affiliation:
Faculty of Veterinary and Animal Sciences, Lasbela University of Agriculture, Water and Marine Sciences, 3800, Uthal, Balochistan, Pakistan
A.A. KAMBOH
Affiliation:
Department of Clinical Pharmacy, School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing, Jiangsu Province, 211198, China
A. MOSHAVERI
Affiliation:
Department of Veterinary Microbiology, Faculty of Animal Husbandry and Veterinary Sciences, Sindh Agriculture University Tandojam 70060, Pakistan
F. MODARRESI-GHAZANI
Affiliation:
Faculty of Veterinary Medicine, Karaj Branch, Islamic Azad University, Karaj, Iran
V. HEJAZI
Affiliation:
Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
S. CHAO*
Affiliation:
Department of Animal Nutrition, College of Animal Sciences and Technology, Northwest A&F University, Yangling, China, 712100
*
Corresponding author: sunchao2775@163.com
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Abstract

Echinacea purpurea is one of the most widely used medicinal herbs that is of interest to animal scientists due to its valuable immuno-stimulatory and anti-inflammatory properties. It is thought that it activates the immune system through stimulating T-cell production, lymphocytic activity, phagocytosis, cellular respiration and inhibiting the secretion of the hyaluronidase enzyme. Chicoric acid (CA) is a major active constituent of Echinacea purpurea. The CA content in roots ranges between 16.80-24.30 mg/g which has gained a lot of renown due to its promising bio-activities. CA has shown to simulate growth promoters and have antioxidant, anti-diabetic, anti-inflammatory, anti-HIV, anti-bacterial, hypoglycaemic and hepatocyte protective properties. There have been very few studies relevant to CA and its use in poultry diets. Previously published studies have included pharmacological and nutritional investigations in the poultry industry. CA could be used as an alternative to antibiotics, and may improve meat quality and health status in broiler chickens.

Keywords

Chicoric acidEchinacea plantfeed additiveimmuno stimulantpoultry

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Type
Reviews
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World's Poultry Science Journal , Volume 74 , Issue 1 , March 2018 , pp. 69 - 78
Copyright
Copyright © World's Poultry Science Association 2018 

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References

AHMED, H.S., KAMEL, K., EL-SABEIY, M. and ZEITOUNY, M. (2008) Effect of echinacea extract supplementation on growth performance and hemo-biochemical traits of growing rabbits. Egypt Poultry Science 28: 1165-1180.Google Scholar
AITUAN, M.A., SHI, W., NIU, X., WANG, M. and ZHONG, X. (2009) Effects of echinacea purpurea extract on the immunological response to infectious bursal disease vaccine in broilers. Frontiers of Agriculture in China 3: 452-456.Google Scholar
BARNES, J., ANDERSON, L.A., GIBBONS, S. and PHILLIPSON, J.D. (2005) Echinacea species (echinacea angustifolia (dc.) hell., echinacea pallida (nutt.) nutt., echinacea purpurea (l.) moench): A review of their chemistry, pharmacology and clinical properties. Journal of Pharmacy and Pharmacology 57: 929-954.Google Scholar
BARNES, P.M., POWELL-GRINER, E., MCFANN, K. and NAHIN, R.L. (2004) Complementary and alternative medicine use among adults: United states, 2002. Proceedings of the Seminars in Integrative Medicine 2 (2): 54-71.CrossRefGoogle Scholar
BAUER, R. (1996) Echinacea-drogen: Wirkungen und wirksubstanzen. Zeitschrift Für Ärztliche Fortbildung 90: 111-115.Google Scholar
BAUER, R. and WAGNER, H. (1991) Echinacea species as potential immunostimulatory drugs, in: Economic and Medicinal Plant Research, pp. 253-321 (Academic Press 5, New York).Google Scholar
BINNS, S.E., HUDSON, J., MERALI, S. and ARNASON, J.T. (2002) Antiviral activity of characterized extracts from echinacea spp. (heliantheae: Asteraceae) against herpes simplex virus (hsv-i). Planta Medica 68: 780-783.Google Scholar
BODINET, C. and FREUDENSTEIN, J. (1999) Effects of an orally applied aqueous-ethanolic extract of a mixture of thujae occidentalis herba, baptisiae tinctoriae radix, echinaceae purpureae radix and echinaceae pallidae radix on antibody response against sheep red blood cells in mice. Planta Medica 65: 695-699.Google Scholar
CLIFFORD, L.J., NAIR, M.G., RANA, J. and DEWITT, D.L. (2002) Bioactivity of alkamides isolated from echinacea purpurea (l.) moench. Phytomedicine 9: 249-253.Google Scholar
DUSSAULT, I. and MILLER, S.C. (1993) Stimulation of natural killer cell numbers but not function in leukemic infant mice: A system primed in infancy allows survival in adulthood. Natural Immunity 12: 66.Google Scholar
FARD, M.H.B., FEIZI, A. and BIJANZAD, P. (2010) Effect of echinacea purpurea dried extract effect on producing antibody from newcastle disease vaccine in broilers by hi test. Journal of Veterinary Research 65: 119-168.Google Scholar
GURBUZ, E., BALEVI, T., KURTOGLU, V., COSKUN, B., OZNURLU, Y., KAN, Y. and KARTAL, M. (2010) Effects of echinacea extract on the performance, antibody titres, and intestinal histology of layer chicks. British Poultry Science 51: 805-810.CrossRefGoogle ScholarPubMed
HARTWICH, M. (2010) The importance of immunological studies on rhodiola rosea in the new effective and safe herbal drug discovery. Central European Journal of Immunology 35: 263-266.Google Scholar
HU, C. and KITTS, D.D. (2000) Studies on the antioxidant activity of echinacea root extract. Journal of Agricultural and Food Chemistry 48: 1466-1472.Google Scholar
IJI, P.A., SAKI, A. and TIVEY, D.R. (2001) Body and intestinal growth of broiler chicks on a commercial starter diet. 1. Intestinal weight and mucosal development. British Poultry Science 42: 505-513.Google Scholar
KOUR, K. and BANI, S. (2011) Augmentation of immune response by chicoric acid through the modulation of cd28/ctla-4 and th1 pathway in chronically stressed mice. Neuropharmacology 60: 852-860.Google Scholar
LAASONEN, M., WENNBERG, T., HARMIA-PULKKINEN, T. and VUORELA, H. (2002) Simultaneous analysis of alkamides and caffeic acid derivatives for the identification of echinacea purpurea, echinacea angustifolia, echinacea pallida and parthenium integrifolium roots. Planta Medica 68: 572-574.Google Scholar
LANDMANN, M., KANURI, G., SPRUSS, A., STAHL, C. and BERGHEIM, I. (2014) Oral intake of chicoric acid reduces acute alcohol-induced hepatic steatosis in mice. Nutrition 30: 882-889.Google Scholar
LEE, T.T., CHEN, C.L., WANG, C.C. and YU, B. (2012) Growth performance and antioxidant capacity of broilers supplemented with echinacea purpurea l. In the diet. Journal of Applied Poultry Research 21: 484-491.Google Scholar
LIU, Q., CHEN, Y., SHEN, C., XIAO, Y., WANG, Y., LIU, Z. and LIU, X. (2017) Chicoric acid supplementation prevents systemic inflammation-induced memory impairment and amyloidogenesis via inhibition of nf-κb. Faseb Journal Official Publication of the Federation of American Societies for Experimental Biology 31: 1494.CrossRefGoogle ScholarPubMed
MA, A., NIU, X. and ZHONG, X. (2013) Effects of echinacea purpurea extracts and astragalus extracts on immunological response to infectious bursal disease vaccination in broilers. American Journal of Traditional Chinese Veterinary Medicine 8: 39-48.Google Scholar
MANAYI, A., MIRNEZAMI, T., SAEIDNIA, S. and AJANI, Y. (2012) Pharmacognostical evaluation, phytochemical analysis and antioxidant activity of the roots of achillea tenuifolia lam. Pharmacognosy Journal 4: 14-19.Google Scholar
MANAYI, A., VAZIRIAN, M. and SAEIDNIA, S. (2015) Echinacea purpurea: Pharmacology, phytochemistry and analysis methods. Pharmacognosy Reviews 9: 63-72.Google Scholar
MATTHIAS, A., BANBURY, L., BONE, K.M., LEACH, D.N. and LEHMANN, R.P. (2008) Echinacea alkylamides modulate induced immune responses in t-cells. Fitoterapia 79: 53-58.Google Scholar
MULLER-JAKIC, B., BREU, W., PROBSTLE, A., REDL, K., GREGER, H. and BAUER, R. (1994) In vitro inhibition of cyclooxygenase and 5-lipoxygenase by alkamides from echinacea and achillea species. Planta Medica 60: 37-40.CrossRefGoogle ScholarPubMed
MØLGAARD, P., JOHNSEN, S., CHRISTENSEN, P. and CORNETT, C. (2003) HPLC method validated for the simultaneous analysis of cichoric acid and alkamides in echinacea purpurea plants and products. Journal of Agricultural & Food Chemistry 51: 6922-6933.CrossRefGoogle ScholarPubMed
NASIR, Z. and GRASHORN, M.A. (2010) Effects of intermittent application of different echinacea purpurea juices on broiler performance and some blood parameters. Archiv für Geflügelkunde 74: 36-42.Google Scholar
NILANTHI, D., CHEN, X.L., ZHAO, F.C., YANG, Y.S. and WU, H. (2009) Induction of tetraploids from petiole explants through colchicine treatments in echinacea purpurea l. Journal of Biomedicine and Biotechnology: Article ID 343485.Google Scholar
NUISSIER, G., REZZONICO, B. and GRIGNON-DUBOIS, M. (2010) Chicoric acid from syringodium filiforme. Food Chemistry 120: 783-788.Google Scholar
ORHAN, I., SENOL, F.S., GULPINAR, A.R., KARTAL, M., SEKEROGLU, N., DEVECI, M., KAN, Y. and SENER, B. (2009) Acetylcholinesterase inhibitory and antioxidant properties of cyclotrichium niveum, thymus praecox subsp. Caucasicus var. Caucasicus, echinacea purpurea and e. Pallida. Food Chemistry and Toxicology 47: 1304-1310.Google Scholar
OU, Z.Q., SCHMIERER, D.M., RADES, T., LARSEN, L. and MCDOWELL, A. (2013) Application of an online post-column derivatisation hplc-dpph assay to detect compounds responsible for antioxidant activity in sonchus oleraceus l. Leaf extracts. Journal of Pharmacy and Pharmacology 65: 271-279.CrossRefGoogle Scholar
PERCIVAL, S.S. (2000) Use of echinacea in medicine. Biochemical Pharmacology 60: 155-158.Google Scholar
PLESCHKA, S., STEIN, M., SCHOOP, R. and HUDSON, J.B. (2009) Anti-viral properties and mode of action of standardized echinacea purpurea extract against highly pathogenic avian influenza virus (h5n1, h7n7) and swine-origin h1n1 (s-oiv). Virology Journal 90: 1-9.Google Scholar
QU, L., CHEN, Y., WANG, X., SCALZO, R. and DAVIS, J.M. (2005) Patterns of variation in alkamides and cichoric acid in roots and aboveground parts of echinacea purpurea (l.) moench. Horticulture Science 40: 1239-1242.Google ScholarPubMed
ROBINSON, W.E. (Jr) (1998) L-chicoric acid, an inhibitor of human immunodeficiency virus type 1 (hiv-1) integrase, improves on the in vitro anti-hiv-1 effect of zidovudine plus a protease inhibitor (ag1350). Antiviral Research 39: 101-111.Google Scholar
SAEIDNIA, S., GOHARI, A., MOKHBER-DEZFULI, N. and KIUCHI, F. (2011) A review on phytochemistry and medicinal properties of the genus achillea. Daru-Journal of Pharmaceutical Sciences 19: 173-186.Google Scholar
SAHIN, T., KAYA, Ö. and SARı, M. (2012) Effects of ground echinacea (echinacea purpurea) supplementation quail diets on growth performance and carcass traits. Kafkas Üniversitesi Veteriner Fakültesi Dergisi 18: 15-19.Google Scholar
SKWAREK, T., TYNECKA, Z., GLOWNIAK, K. and LUTOSTANSKA, E. (1996) Echinacea l. - inducer of interferons. Herba Polonica 42: 110-117.Google Scholar
THOMPSON, K.D. (1998) Antiviral activity of viracea against acyclovir susceptible and acyclovir resistant strains of herpes simplex virus. Antiviral Research 39: 55-61.Google Scholar
THYGESEN, L., THULIN, J., MORTENSEN, A., SKIBSTED, L.H. and MOLGAARD, P. (2007) Antioxidant activity of cichoric acid and alkamides from echinacea purpurea, alone and in combination. Food Chemistry and Toxicology 101: 74-81.Google Scholar
TRAGNI, E., TUBARO, A., MELIS, S. and GALLI, C.L. (1985) Evidence from two classic irritation tests for an anti-inflammatory action of a natural extract, echinacina b. Food Chemistry and Toxicology 23: 317-319.CrossRefGoogle ScholarPubMed
TSAI, K.L., KAO, C.L., HUNG, C.H., CHENG, Y.H., LIN, H.C. and CHU, P.M. (2017) Chicoric acid is a potent anti-atherosclerotic ingredient by anti-oxidant action and anti-inflammation capacity. Oncotarget 8: 29600-29612.CrossRefGoogle ScholarPubMed
TSAI, Y.L., CHIOU, S.Y., CHAN, K.C., SUNG, J.M. and LIN, S.D. (2012) Caffeic acid derivatives, total phenols, antioxidant and antimutagenic activities of echinacea purpurea flower extracts. LWT-Food Science and Technology 46: 169-176.Google Scholar
VOITENKO, G., VARCHENKO, V., LIPKAN, G., OLINICHENKO, P., MYASOYEDOV, D., MHITARIAN, L., KUTNIAK, V., OBEDKOVA, N., KUKHAR, I. and YAKOVLEVA, N. (1996) Influence of preparations from the roots and flowers of echinacea purpurea on the course of the inflammatory reaction under experimental conditions. Farmatsevtychnyĭ zhurnal 2: 115-121.Google Scholar
WACKER, A. and HILBIG, W. (1978) [virus-inhibition by echinacea purpurea (author's transl)]. Planta Medica 33: 89-102.Google Scholar
WAGNER, H. (1986) Examination of the immune-stimulation effect of some plant homeopathic drugs. Biological Therapy 4: 21-27.Google Scholar
WAGNER, H. (1989) Search for new plant constituents with potential antiphlogistic and antiallergic activity. Planta Medica 55: 235-241.Google Scholar
WILLS, R.B.H. and STUART, D.L. (1999) Alkylamide and cichoric acid levels in echinacea purpurea grown in Australia. Food Chemistry 67: 385-388.Google Scholar
WOELKART, K., MARTH, E., SUTER, A., SCHOOP, R., RAGGAM, R.B., KOIDL, C., KLEINHAPPL, B. and BAUER, R. (2006) Bioavailability and pharmacokinetics of echinacea purpurea preparations and their interaction with the immune system. International Journal of Clinical Pharmacology and Therapeutics 44: 401-408.CrossRefGoogle ScholarPubMed
YAODI, N.I., ZHONG, X., NIU, X., LI, X.U., WEI, S. and CHEN, M. (2008) Effect of echinacea purpurea extracts and astragalus extractions on immune regulation to infectious bursal disease vaccine and production performance in chicken. China Poultry 16: 004.Google Scholar
ZADEH, Z.T., RAHIMI, S., TORSHIZI, M.A.K. and OMIDBAIGI, R. (2009) The effects of thymus vulgaris l., echinacea purpurea (l.) moench., allium sativum l. Extracts and virginiamycin antibiotic on intestinal microflora population and immune system in broilers. Iranian Journal of Medicinal & Aromatic Plants 2: 39-48.Google Scholar
ZHU, D., WANG, Y., DU, Q., LIU, Z. and LIU, X. (2015) Cichoric acid reverses insulin resistance and suppresses inflammatory responses in the glucosamine-induced hepg2 cells. Journal of Agriculture Food Chemistry 63: 10903-10913.Google Scholar