Hostname: page-component-745bb68f8f-g4j75 Total loading time: 0 Render date: 2025-01-11T12:57:20.635Z Has data issue: false hasContentIssue false
  • English
  • Français

Retinal neuromodulation: The role of dopamine

Published online by Cambridge University Press:  02 June 2009

John E. Dowling
John E. Dowling
Affiliation:
Department of Cellular and Developmental Biology, Harvard University, Cambridge
Get access Rights & Permissions [Opens in a new window]

Abstract

Dopamine exerts multiple effects on retinal horizontal cells. Dopamine, via cyclic AMP and protein kinase A, reduces the light responsiveness of horizontal cells and the electrical coupling between the cells. The gating kinetics of both gap-junctional and glutamate channels are altered as a result of phosphorylation by protein kinase A. Dopamine also causes a reversible retraction of neurites of horizontal cells maintained in culture. Diacylglycerol analogues as well as phorbol esters mimic this effect of dopamine, but not cyclic AMP analogues or Forskolin. The results suggest that dopamine causes neurite retraction by the activation of protein kinase C via diacylglycerol.

Keywords

Horizontal cellsCyclic AMPProtein kinase ADiacylglycerolProtein kinase C
Type
Research Articles
Information
Visual Neuroscience , Volume 7 , Issue 1-2 , August 1991 , pp. 87 - 97
Copyright
Copyright © Cambridge University Press 1991

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Boycott, B.B., Dowling, J.E., Fisher, S.K., Kolb, H. & Laties, A.M. (1975). Interplexiform cells of the mammalian retina and their comparison with catecholamine-containing retinal cells. Proceedings of the Royal Society (London) 191, 353–368.Google Scholar
Dejuan, J., Iniquez, C. & Dowling, J.E. (1990). Influence of dopamine on spinules, synaptic ribbons, and nematosomes in white perch retina. Investigative Ophthalmology and Visual Science (Suppl.) 31, 333.Google Scholar
Dowling, J.E. & Ehinger, B. (1975). Synaptic organization of the amine-containing interplexiform cells of the goldfish and Cebus monkey retina. Science 188, 270–273.Google Scholar
Dowling, J.E. & Ehinger, B. (1978). The interplexiform cell system. I. Synapses of the dopaminergic neurons of the goldfish retina. Proceedings of the Royal Society (London) 201, 7–26.Google Scholar
Dowling, J.E. & Watling, K.J. (1981). Dopaminergic mechanisms in the teleost retina, I: Dopamine-sensitive adenylate cylcase in the homogenates of carp retina: effects of agonists, antagonists, and ergot. Journal of Neurochemistry 36, 569–579.CrossRefGoogle Scholar
Dowling, J.E., Pak, M.W. & Lasater, E.M. (1985). White perch horizontal cells in culture: methods, morphology, and process growth. Brain Research 360, 331–338.Google Scholar
Ehinger, B. & Dowling, J.E. (1987). Retinal neurocircuitry and transmission. In Handbook of Chemical Neuroanatomy, Vol. 5, ed. Bjorklund, A., Hokfelt, T. & Swanson, L.W., pp. 389–446. Amsterdam: Elsevier.Google Scholar
Ehinger, B., Falck, B. & Laties, A.M. (1969). Adrenergic neurons in teleoest retina. Zeitschrift für Zellforschung 97, 285–297.CrossRefGoogle ScholarPubMed
Gallego, A. (1971). Horizontal and amacrine cells in the mammal's retina. Vision Research 3, 33–50.Google Scholar
Greengard, P. (1978). Cyclic Nucleotides, Phosphorylated Proteins, and Neuronal Function. New York: Raven Press.Google Scholar
Hedden, W.L. & Dowling, J.E. (1978). The interplexiform cell system, II: Effects of dopamine on goldfish retinal neurons. Proceedings of the Royal Society B 201, 27–55.Google Scholar
Iversen, L. (1987). Neurotransmitters. In Encyclopedia of Neuroscience, pp. 856–858. Boston: Birkhauser.Google Scholar
Knapp, A.G. & Dowling, J.E. (1987). Dopamine enhances excitatory amino acid-gated conductances in retinal horizontal cells. Nature 325, 437–439.CrossRefGoogle ScholarPubMed
Knapp, A.G., Schmidt, K.F. & Dowling, J.E. (1990). Dopamine modulates the kinetics of ion channels gated by excitatory amino acids in retinal horizontal cells. Proceedings of the National Academy of Sciences of the U.S.A. 87, 767–771.Google Scholar
Kohler, K. & Weiler, R. (1990). Influence of cAMP and PKC on spinule formation in the fish retina. Investigative Ophthalmology and Visual Science (Suppl.) 31, 333.Google Scholar
Lasater, E.M. (1987). Retinal horizontal cell gap-junctional conductance is modulated by dopamine through a cyclic AMP-dependent protein kinase. Proceedings of the National Academy of Sciences of the U.S.A. 84, 7319–7323.CrossRefGoogle ScholarPubMed
Lasater, E.M. & Dowling, J.E. (1982). Carp horizontal cells in culture respond selectively to L-glutamate and its agonists. Proceedings of the National Academy of Sciences of the U.S.A. 79, 936–940.Google Scholar
Lasater, E.M. & Dowling, J.E. (1985). Dopamine decreases conductance of the electrical junctions between cultured retinal horizontal cells. Proceedings of the National Academy of Sciences of the U.S.A. 82, 3025–3029.Google Scholar
Liman, E.R., Knapp, A.G. & Dowling, J.E. (1989). Enhancement of kainate-gated currents in retinal horizontal cells by cyclic AMP-dependent protein kinase. Brain Research 481, 399–402.Google Scholar
Mangel, S.C. & Dowling, J.E. (1985). Responsiveness and receptive-field size of carp horizontal cells are reduced by prolonged darkness and dopamine. Science 229, 1107–1109.CrossRefGoogle ScholarPubMed
Mangel, S.C. & Dowling, J.E. (1987). The interplexiform horizontal cell system of the fish retina: effects of dopamine, light stimulus, and time in the dark. Proceedings of the Royal Society B (London) 23, 91–121.Google Scholar
Mcmahon, D.G., Knapp, A.G. & Dowling, J.E. (1989). Horizontal cell gap-junction channels: single-channel conductance and modulation by dopamine. Proceedings of the National Academy of Sciences of the U.S.A. 86, 7630–7643.Google Scholar
Negishi, K. & Drujan, M. (1979). Reciprocal changes in center and surrounding S-potentials of fish retina in response to dopamine. Neurochemistry Research 4, 313–318.Google Scholar
Nawy, S. & Jahr, C.E. (1990). Suppression by glutamate of cGMP-activated conductance in retinal bipolar cells. Nature 346, 269–271.Google Scholar
Piccolino, M., Neyton, J. & Gerschenfeld, H.M. (1984). Decrease of gap-junction permeability induced by dopamine and cyclic adenosine 3′,5′ -monophosphate in horizontal cells of turtle retina. Journal of Neuroscience 4, 2477–2488.CrossRefGoogle ScholarPubMed
Piccolino, M., Witkovsky, P. & Trimarchi, C. (1987). Dopaminergic mechanisms underlying the reduction of electrical coupling between horizontal cells of the turtle retina induced by d-amphetamine, bicuculline, and veratridine. Journal of Neuroscience 7, 2273–2284.Google ScholarPubMed
Raynau, J.-P. & Laviolette, J.R. (1979). Goldfish retina: a correlate between cone activity and morphology of the horizontal cells in cone pedicles. Science 204, 1436–1438.CrossRefGoogle Scholar
Rodrigues, P. & Dowling, J.E. (1990). Dopamine induces neurite retraction in horizontal cells via diacylglycerol and protein kinase C. Proceedings of the National Academy of Sciences of the U.S.A. 87, 9693–9697.CrossRefGoogle ScholarPubMed
Teranishi, T., Negishi, K. & Kato, S. (1983). Dopamine modulates S-potential amplitude and dye coupling between external horizontal cells in carp retina. Nature 301, 243–246.Google Scholar
Teranishi, T., Negishi, K. & Kato, S. (1984). Regulatory effect of dopamine on spatial properties of horizontal cells in carp retina. Journal of Neuroscience 4, 1271–1280.Google Scholar
Umino, O., Lee, Y. & Dowling, J.E. (1991). Effects of light stimuli on the release of dopamine from interplexiform cells in the white perch retina. Visual Neuroscience (submitted for publication).CrossRefGoogle Scholar
Van, Buskirk R. & Dowling, J.E. (1981). Isolated horizontal cells from carp retina demonstrate dopamine-dependent accumulation of cyclic AMP. Proceedings of the National Academy of Sciences of the U.S.A. 78, 7825–7829.Google Scholar
Weiler, R. & Wagner, H.-J. (1984). Light-dependent changes of cone-horizontal cell interactions in carp retina. Brain Research 298, 1–9.Google Scholar
Yazulla, S. & Kleinschmidt, J. (1982). Dopamine blocks carrier-mediated release of GABA from retinal horizontal cells. Brain Research 233, 211–215.CrossRefGoogle ScholarPubMed
Zucker, C.L. & Dowling, J.E. (1987). Centrifugal fibers synapse on interplexiform cells in the teleost retina. Nature 330, 166–168.CrossRefGoogle ScholarPubMed