Hostname: page-component-cb9f654ff-5jtmz Total loading time: 0 Render date: 2025-09-08T23:22:36.085Z Has data issue: false hasContentIssue false
  • English
  • Français

GABAA receptors in neurons of the nerve fiber layer in rabbit retina

Published online by Cambridge University Press:  02 June 2009

B. Ehinger  and
C. L. Zucker
B. Ehinger
Affiliation:
Department of Ophthalmology, Lund University Hospital, Lund, Sweden and Schepens Eye Research Institute, and Harvard Medical School, Boston
C. L. Zucker
Affiliation:
Department of Ophthalmology, Lund University Hospital, Lund, Sweden and Schepens Eye Research Institute, and Harvard Medical School, Boston
Get access Rights & Permissions [Opens in a new window]

Abstract

Two synapse-rich layers are well recognized in the mammalian retina, the inner and outer plexiform layers. However, synapses occur also in other layers, particularly in the innermost nerve fiber layer. These synapses form a tenuous layer at times referred to as the superficial plexiform layer. We have found that staining for GABAA receptors in whole-mounted rabbit retina demonstrates this layer. It is most well developed in the region of the visual streak 2–4 mm below the center of the myelinated streak and is very sparse in other parts. Most or all of the processes in the plexus originate from cells in the ganglion cell layer.

Keywords

RetinaGABAA receptorsRabbitSuperficial plexiform layerRetinal ganglion cells

Information

Type
Short Communication
Information
Visual Neuroscience , Volume 13 , Issue 5 , September 1996 , pp. 991 - 994
Copyright
Copyright © Cambridge University Press 1996

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

Article purchase

Temporarily unavailable

References

Ariel, M., Robinson, F.R. & Knapp, A.G. (1988). Analysis of vertebrate eye movements following intravitreal drug injections. II. Spontaneous nystagmus induced by picrotoxin is mediated subcortically. Journal of Neurophysiology 60, 1022–1035.CrossRefGoogle ScholarPubMed
Ariel, M. & Rosenberg, A.F. (1991). Effects of synaptic drugs on turtle optokinetic nystagmus and the spike responses of the basal optic nucleus. Visual Neuroscience 7, 431–440.CrossRefGoogle ScholarPubMed
Ariel, M. & Tusa, R.J. (1992). Spontaneous nystagmus and gaze-holding ability in monkeys after intravitreal picrotoxin injections. Journal of Neurophysiology 67, 1124–1132.CrossRefGoogle ScholarPubMed
Bonaventure, N., Wioland, N. & Bigenwald, J. (1983). Involvement of GABAergic mechanisms in the optokinetic nystagmus of the frog. Experimental Brain Research 50, 433–441.Google ScholarPubMed
Bonaventure, N., Wioland, N. & Jardon, B. (1985). On GABAer-gic mechanisms in the optokinetic nystagmus of the frog: Effects of bicuculline, allylglycine and SR 95103, a new GABA antagonist. European Journal of Pharmacology 118, 61–68.CrossRefGoogle ScholarPubMed
Bonaventure, N., Kim, M.S., Jardon, B. & Yucel, H. (1992). Pharmacological study of the chicken's monocular optokinetic nystagmus: Involvement of the ON retinal channel evidenced by the glutamatergic separation of ON and OFF pathways. Vision Research 32, 601–609.CrossRefGoogle ScholarPubMed
Brecha, N. (1992). Expression of GABAA receptors in the vertebrate retina Progress in Brain Research 90, 3–28.CrossRefGoogle ScholarPubMed
Dawson, W.W. & Lieberman, H. (1979). Evidence of two retinal control loops. In Current Concepts in Ophthalmology, Vol. 6, ed. Kaufman, H.E. & Zimmerman, T., pp. 111–121. St. Louis, Missouri: C.V. Mosby.Google Scholar
Dowling, J.E. (1979). Information processing by local circuits: The vertebrate retina as a model system. In The Neurosciences. Fourth Study Program, ed. Schmitt, F.O. & Worden, F.G., pp. 163–181. Cambridge, Massachusetts: M.I.T. Press.Google Scholar
Dubois, M.F. & Collewijn, H. (1979). The optokinetic reactions of the rabbit: Relation to the visual streak. Vision Research 19, 9–17.CrossRefGoogle Scholar
Ehinger, B. & Zucker, C.L. (1996). Differential distribution of GABAA receptors in identified amacrine cell types in the rabbit retina, (in preparation).CrossRefGoogle Scholar
Ewert, M., De Blas, A.L., Mohler, H. & Seeburg, P.M. (1992). A prominent epitope on GABAA receptors is recognized by two different monoclonal antibodies. Brain Research 569, 57–62.CrossRefGoogle ScholarPubMed
Fritzsch, B. & Collin, S.P. (1990). Dendritic distribution of two populations of ganglion cells and the retinopetal fibers in the retina of the silver lamprey (Ichthyomyzon unicuspis). Visual Neuroscience 4, 533–545.CrossRefGoogle ScholarPubMed
Gallego, A. & Cruz, J. (1965). Mammalian retina: Associational nerve cells in the ganglion cell layer. Science 150, 151–157.CrossRefGoogle Scholar
Greferath, U., Grünert, U., Müller, F. & Wässle, H. (1994). Localization of GABAA receptors in the rabbit retina. Cell and Tissue Research 276, 295–307.Google ScholarPubMed
Holmberg, K. (1977). The cyclostome retina. In The Visual System in Vertebrates. Handbook of Sensory Physiology, Vol. VII/5, ed. Mackay, D.M. & Teuber, H.L., pp. 47–66. New York: Springer-Verlag.CrossRefGoogle Scholar
Koontz, M.A. (1993). GABA-immunoreactive profiles provide synaptic input to the soma, axon hillock, and axon initial segment of ganglion cells in primate retina. Vision Research 33, 2629–2636.CrossRefGoogle Scholar
Koontz, M.A. & Hendrickson, A.E. (1987). Stratified distribution of synapses in the inner plexiform layer of primate retina. Journal of Comparative Neurology 263, 581–592.CrossRefGoogle ScholarPubMed
Koontz, M.A., Hendrickson, A.E. & Ryan, M.K. (1989). GABA-immunoreactive synaptic plexus in the nerve fiber layer of primate retina. Visual Neuroscience 2, 19–25.CrossRefGoogle ScholarPubMed
Marenghi, G. (1900). Contribute alla fina organizzazione della retina. Anatomische Anzeiger 14, 12–16.Google Scholar
Peichl, L. (1989). Alpha and delta ganglion cells in the rat retina. Journal of Comparative Neurology 286, 120–139.CrossRefGoogle ScholarPubMed
Polyak, S.L. (1941). The Retina. The Anatomy and Histology of the Retina in Man, Ape and Monkey, Including the Consideration of Visual Functions, the History of Physiological Optics, and the Histological Laboratory Technique. Chicago, Illinois: University of Chicago Press.Google Scholar
Ramon, S. (1893). La rétine des vertébrés. La Cellule 9, 17–257.Google Scholar
Richards, J.G., Schoch, P., Häring, P., Takacs, B. & Mohler, H. (1987). Resolving GABAA/benzodiazepine receptors: Cellular and subcellular localization in the CNS with monoclonal antibodies. Journal of Neuroscience 7, 1866–1886.CrossRefGoogle ScholarPubMed
Schuerger, R.J., Rosenberg, A.F.. & Ariel, M. (1990). Retinal direction-sensitive input to the accessory optic system: An in vitro approach with behavioral relevance. Brain Research 522, 161–164.CrossRefGoogle Scholar
Somogyi, P., Takagi, H., Richards, J.G. & Mohler, H. (1989). Sub-cellular localization of benzodiazepine/GABAA receptors in the cerebellum of rat, cat, and monkey using monoclonal antibodies. Journal of Neuroscience 9, 2197–2209.CrossRefGoogle Scholar
Wieniawa-Narkiewicz, E. & Hughes, A. (1992). The superficial plexiform layer: A third retinal association area. Journal of Comparative Neurology 324, 463–484.CrossRefGoogle Scholar