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Tiapride in the Long-term Management of Alcoholics of Anxious or Depressive Temperament

Published online by Cambridge University Press:  02 January 2018

G. K. Shaw ,
S. K. Majumdar ,
S. Waller ,
J. MacGarvie  and
G. Dunn
G. K. Shaw*
Affiliation:
Bexley Hospital
S. K. Majumdar
Affiliation:
Bexley Hospital
S. Waller
Affiliation:
Bexley Hospital
J. MacGarvie
Affiliation:
Biometrics Unit, Institute of Psychiatry, London
G. Dunn
Affiliation:
Biometrics Unit, Institute of Psychiatry, London
*
∗Bexley Hospital, Old Bexley Lane, Bexley, Kent DAS 2BW
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Abstract

Thirty-two chemically dependent alcoholics with significant levels of anxiety or depression were admitted to a double-blind randomised study in which the effect of the substituted benzamide tiapride was compared with that of placebo over a 6-month period. Twenty patients completed the study. Assessments included relevant biochemical and haematological tests, drinking levels and associated behaviour, expressed satisfaction with various areas of life, the Crown-Crisp Experiential Index of neurotic symptoms and questionnaires on self-esteem and alcohol dependence. The results indicated that in comparison with the placebo group, patients treated with tiapride drank less and had longer periods of abstinence. This was associated with improvements in laboratory tests, reduction in neurotic symptoms, gains in self-esteem and increased levels of expressed satisfaction with life situation. The drug was well tolerated and no deleterious effects were noted, suggesting its potential usefulness for this patient group.

Type
Research Article
Information
The British Journal of Psychiatry , Volume 150 , Issue 2 , February 1987 , pp. 164 - 168
Copyright
Copyright © 1987 The Royal College of Psychiatrists 

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