Hostname: page-component-857557d7f7-c8jtx Total loading time: 0 Render date: 2025-11-23T16:58:36.575Z Has data issue: false hasContentIssue false
  • English
  • Français

Intermittent Medication, Coping and Psychotherapy Interactions in Relapse Prevention and Course Modification

Published online by Cambridge University Press:  06 August 2018

Peter Müller ,
Borwin Bandelow ,
Wolfgang Gaebel ,
Wolfgang Köpcke ,
Michael Linden ,
Franz Müller-Spahn ,
Adolf Pietzcker ,
Elke Schaefer  and
Joachim Tegeler
Peter Müller*
Affiliation:
Pychiatrische Universitätsklinik, Von-Siebold-Str. 5, D-3400 Göttingen
Borwin Bandelow
Affiliation:
Pychiatrische Universitätsklinik, Von-Siebold-Str. 5, D-3400 Göttingen
Wolfgang Gaebel
Affiliation:
Psychiatrische Universitätsklinik FU, Berlin
Wolfgang Köpcke
Affiliation:
Psychiatrische Universitätsklinik FU, Berlin
Michael Linden
Affiliation:
Psychiatrische Universitätsklinik FU, Berlin
Franz Müller-Spahn
Affiliation:
Pychiatrische Universitätsklinik, Von-Siebold-Str. 5, D-3400 Göttingen
Adolf Pietzcker
Affiliation:
Psychiatrische Universitätsklinik FU, Berlin
Elke Schaefer
Affiliation:
Pychiatrische Universitätsklinik, Von-Siebold-Str. 5, D-3400 Göttingen
Joachim Tegeler
Affiliation:
Psychiatrische Universitätsklinik, Düsseldorf, Germany
*
Correspondence
Get access Rights & Permissions [Opens in a new window]

Extract

There has been increasing interest in intermittent medication as a viable alternative to continuous neuroleptic treatment for chronic schizophrenic patients. Considerations supporting the plausibility of a targeted-medication approach include the fact that long-term medication involves certain risks, and that neither favourable outcome in the long-term nor risk of relapse are necessarily dependent on the continuous administration of neuroleptic drugs. An intermittent-targeted administration strategy was developed by Herz et al (1989) in an attempt to abort relapses at an early stage and to stabilise or to improve the course taken by illness.

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

Article purchase

Temporarily unavailable

References

Aitken, R. C. B. (1969) Measurement of feeling using visual analogue scales. Proceedings of the Royal Society of Medicine, 62, 989–993.Google Scholar
Böker, W., Brenner, H. D. & Alberti, L. (1982) Über eine Untersuchung subjektiver Neuroleptikawirkung bei Schizophrenen. In Psychopharmakotherapie (ed. Haase, H. J.), pp. 87–108. Erlangen: Perimed.Google Scholar
Böker, W., Brenner, H. D. & Alberti, L. (1983) Selbstheilungsversuche Schizophrener. Nervenarzt, 54, 578–589.Google Scholar
Böker, W., Brenner, H. D. & Würgler, S. (1989) Vulnerabilitätsverbundene Defizienzen, Psychopathologie und Bewältigungsverhalten bei Schizophrenen und deren Angehörigen. In Schizophrenie als Systemische Störung (eds W. Böker & H. D. Brenner), pp. 283–299. Bern: Huber.Google Scholar
Brenner, H. D. (1989) Die Therapie basaler psychischer Dysfunktionen aus systemischer Sicht. In Schizophrenie als Systemische Störung (eds W. Böker & H. D. Brenner), pp. 170–188. Bern: Huber.Google Scholar
Brenner, H. D., Böker, W. & Rui, C. (1986) Subjektive Neuroleptikawirkung bei Schizophrenen und ihre Bedeutung für die Therapie. In Seiteneffekte und Störwirkungen der Psychopharmaka (eds H. Hinterhuber, H. Schubert & F. Kulhanek), pp. 97–107. Stuttgart: Schattauer.Google Scholar
Brenner, H. D., Böker, W., Müller, J., et al (1987) On autoprotective efforts of schizophrenics, neurotics and controls. Acta Psychiatrica Scandinavica, 75, 405–414.CrossRefGoogle ScholarPubMed
Carpenter, W. T., Heinrichs, D. W. & Hanlon, T. E. (1987) A comparative trial of pharmacologic strategies in schizophrenia. American Journal of Psychiatry, 144, 1466–1470.Google Scholar
Carpenter, W. T., Heinrichs, D. W. & Hanlon, T. E., et al (1990) Continuous v. targeted medication in schizophrenic outpatients: outcome results. American Journal of Psychiatry, 147, 1138–1142.Google Scholar
Heinrich, K. & Tegeler, J. (1983) Dyskognitive, apathische und extrapyramidale Syndrome bei Langzeit-Neurolepsie. In Therapie mit Neuroleptika (eds H. Hippius & H. E. Klein), pp. 194–202. Erlangen: Perimed.Google Scholar
Herz, M. I., Glazer, W., Mirza, M., et al (1989) Die Behandlung prodromaler Episoden zur Prävention von Rückfällen in der Schizophrenic In Schizophrenie als Systemische Stöning (eds W. Böker & H. D. Brenner), pp. 270–282. Bern: Huber.Google Scholar
Herz, M. I., Glazer, W., Mostert, M. A., et al (1991) Intermittent vs maintenance medication in schizophrenia. Archives of General Psychiatry, 48, 333–339.Google Scholar
Jerusalem, M. (1990) Persönliche Ressourcen, Vulnerability und Stresserleben. Göttigen: Psychologic Google Scholar
Jolley, A. G., Hirsch, S. R., McRink, A., et al (1989) Trial of brief intermittent neuroleptic prophylaxis for selected schizophrenic outpatients: clinical outcome at one year. British Medical Journal, 298, 985–990.Google Scholar
Jolley, A. G., Hirsch, S. R., Morrison, E., et al (1990) Trial of brief intermittent neuroleptic prophylaxis for selected schizophrenic outpatients: clinical and social outcome at two years. British Medical Journal, 301, 837–842.CrossRefGoogle ScholarPubMed
Linden, M., Nather, J. & Wilms, H. U. (1988) Zur Definition, Bedeutung und Messung der Krankheitskonzepte von Patienten. Die Krankheitskonzeptskala (KK-Skala) für schizophrene Patienten. Fortschritte der Neurologie und Psychiatrie, 56, 35–43.Google Scholar
Müller, P. (1983) Was sollen wir Schizophrenen raten: Medikamentöse Langzeitprophylaxe oder Intervallbehandlung? Nervenarzt, 54, 477–485.Google Scholar
Müller, P. (1990) Neuroleptikainduzierte Depressionen – Tatsache oder Fiktion? In Leitlinien neuroleptischer Therapie (ed. Heinrich, K.), pp. 239–248. Berlin: Springer.Google Scholar
Müller, P. (1991) Psychotherapie bei schizophrenen Psychosen – historische Entwicklung, Effizienz und gegenwärtig Anerkanntes. Fortschritte in Neurologie und Psychiatrie, 59, 277–285.CrossRefGoogle Scholar
Pietzcker, A., Gaebel, W., Köpcke, W., et al (1986) A German multicenter study on the neuroleptic long-term therapy of schizophrenic patients. Preliminary report. Pharmacopsychiatry, 19, 161–166.CrossRefGoogle Scholar
Pietzcker, A., Gaebel, W., Köpcke, W., et al (1992) Intermittent vs maintenance neuroleptic long-term treatment in schizophrenia – two year results of a German multicenter study (unpublished).Google Scholar
Post, R. M., Ruvinow, D. R. & Ballenger, J. C. (1986) Conditioning and sensitisation in the longitudinal course of affective illness. British Journal of Psychiatry, 149, 191–201.Google Scholar
Süllwold, L. (1982) Zum Einfluss von Sekundärreaktionen auf die Langzeitentwicklung schizophrener Psychosen. In Biologische Psychiatrie (Ed. H. Beckmann). Stuttgart: Thieme.Google Scholar
Von Zerssen, D. & V. Koeller, D. M. (1976) Paranoid-Depressivitats-Skala. Weinheim: Beltz.Google Scholar
Submit a response

eLetters

No eLetters have been published for this article.