Hostname: page-component-857557d7f7-zntvd Total loading time: 0 Render date: 2025-11-27T21:38:54.212Z Has data issue: false hasContentIssue false
  • English
  • Français

Decarboxylation of Radioactive DOPA by Erythrocytes in Schizophrenia

Published online by Cambridge University Press:  29 January 2018

Ngo Tran ,
Marcel Laplante  and
Etienne Lebel
Ngo Tran
Affiliation:
Centre Hospitalier Universitaire, Sherbrooke, Quebec, Canada
Marcel Laplante
Affiliation:
Centre Hospitalier Universitairey Sherbrooke, Quebec, Canada
Etienne Lebel
Affiliation:
Centre Hospitalier Universitaire, Sherbrooke, Quebec, Canada
Get access Rights & Permissions [Opens in a new window]

Extract

The decarboxylation of 3, 4-dihydroxyphenyl-alanine (Dopa) to dopamine has been shown previously in animal and human tissues in both in vitro and in vivo studies (Sourkes, 1966; Vogel et al., 1970). However, very little information is available as to whether or not the decarboxylation of Dopa occurs in human red blood cells (RBC). In the present experiment we demonstrated this change in RBC from normals and from schizophrenics. An ionization chamber method was used for an instantaneous and continuous measurement of 14CO2 production from DL-dopa-carboxyl-14C by RBC in vitro.

Information

Type
Abstract
Information
The British Journal of Psychiatry , Volume 118 , Issue 545 , April 1971 , pp. 465 - 466
Copyright
Copyright © Royal College of Psychiatrists, 1971 

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

Article purchase

Temporarily unavailable

References

Frohman, G. E., Warner, K. A., Yoon, H. S., Arthur, R. E., and Gottlieb, J. S. (1969). Biological Psychiatry, 1, 377.Google Scholar
ISRAELSTAM, D. M., SARGENT, T., FlNLEY, N. N., Winchell, H. S., Fish, B. M., Motto, J., Pollycove, M., and Johnson, A. (1970). J. psychiat. Res., 7, 185.CrossRefGoogle Scholar
Sourkes, T. L. (1966). Pharmacological Reviews, 18, 53.Google Scholar
Tolbert, B. M., Kirk, M., and Baker, E. M. (1956). American Journal of Physiology, 185, 269.Google Scholar
Tolbert, B. M., Kirk, M., and Upham, F. (1959). Review of Scientific Instruments, 30, 116.Google Scholar
Tran, N. (1969). Ph.D. Thesis, Univ. of California, Berkeley.Google Scholar
Vogel, W. H., McFarland, H., and Prince, L. N. (1970). Biochemical Pharmacology, 19, 618.Google Scholar

This journal is not currently accepting new eletters.

eLetters

No eLetters have been published for this article.