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Clinical Trial of a Test Stick to Control Patient Compliance under Nomifensine Treatment

Published online by Cambridge University Press:  29 January 2018

M. Linden ,
G. Schüssler  and
B. Müller-Oerlinghausen
M. Linden
Affiliation:
Department of Psychiatry
G. Schüssler
Affiliation:
Department of Psychiatry
B. Müller-Oerlinghausen
Affiliation:
Laboratory of Clinical Psychopharmacology, Department of Psychiatry Freie Universität Berlin, Eschenallee 3, D–1000 Berlin 19
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Summary

A reliable and rapid way of assessing patient compliance is the use of a semi-quantitative drug determination in the urine. Almost all urines were positive to a microchromatographic test stick 2–6 hours after 25 or 100 mg nomifensine was taken orally by healthy normal volunteers. The test reliability between different observers varied between 76 and 100 per cent. False positive results were regularly observed with carbamazepine and triamterene, and false negatives or weakened reactions with lithium.

The test is reliable and highly ‘time-specific‘. Its applicability is, therefore, restricted to very specific questions.

Type
Research Article
Information
The British Journal of Psychiatry , Volume 140 , Issue 1 , January 1982 , pp. 50 - 54
Copyright
Copyright © The Royal College of Psychiatrists 

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References

Cameron, R. (1978) The clinical implementation of behavior change techniques. A cognitively oriented conceptualization of therapeutic “compliance” and “resistance”. In Cognitive Behavior Therapy (eds. Foreyt, J. P. and Rathjen, D. P.). New York: Plenum.Google Scholar
Caron, H. S. & Roth, H. P. (1968) Patient cooperation with a medical regimen. Difficulties in identifying the non-cooperator. Journal of the American Medical Association, 203, 120–4.Google Scholar
Clarke, E. G. C. (ed.) (1971) Isolation and Identification of Drugs. London: The Pharmaceutical Press.Google Scholar
Gordis, L., Markowitz, M. & Lilienfeld, A. M. (1969) The inaccuracy in using interviews to estimate patient reliability in taking medications at home. Medical Care, 7, 49—54.Google Scholar
Gundert—Remy, U. (1980) Compliance. Arzneimittel-Forschung (Drug Research), 30, 1174–5.Google Scholar
Hermann, U. (1979) Medizin-soziologische Analyse der Einflussfaktoren auf “Compliance”. Nervenarzt, 50, 102–8.Google ScholarPubMed
Hornke, I., Cavagna, F.O.C. et al (1977) Pharmakokinetik und Metabolismus von Nomifensin. In Alivaly (Nomifensin) (ed. Hoechst, A.G., Abteilung, Medizinische). Pp 99–104. Stuttgart and New York: F. K. Schattauer.Google Scholar
Johnson, D. A. W. & Freeman, H. (1973) Drug defaulting by patients on long-acting phenothiazines. Psychological Medicine, 4, 1—7.Google Scholar
Linden, M. (1979) Therapeutische Ansätze zur Verbesserung von “Compliance”. Nervenarzt, 50, 109–14.Google ScholarPubMed
Linden, M. (1980) Compliance und Compliance-Modifikation. In Entwicklung der Verhaltenstherapie in der Praxis (ed. Brengelmann, J. C.). Munich: Röttger.Google Scholar
Linden, M. (1981) Definition of compliance. International Journal of Clinical Pharmacology and Toxicology, 19, 86—90.Google Scholar
Müller-Oerlinghausen, B. (1978) Bedeutung der Pharmakokinetik für die Therapie mit Antidepressiva. Pharmacopsychiatria, 11, 55—62.Google Scholar
Rickels, K. & Downing, R. (1966) Compliance and improvement in drug-treated and placebo-treated neurotic outpatients. Archives of General Psychiatry, 14, 631–3.CrossRefGoogle ScholarPubMed
Rickels, K. & Briscol, E. (1970) Assessment of dosage deviation in outpatient drug research. Journal of Clinical Pharmacology, 10, 153–60.Google ScholarPubMed
Scoutter, B. R. & Kennedy, M. C. (1974) Patient compliance assessment in drug trials: usage and methods. Australian and New Zealand Journal of Medicine, 4, 360–4.Google Scholar
Uhlenhuth, E. H., Park, L. C., Lipman, R. S., Rickels, K., Fisher, S. & Mock, J. (1965) Dosage deviation and drug effects in drug trials. Journal of Nervous and Mental Disease, 141, 95–9.Google Scholar
Uihlein, M. (1979) Vorrichtung zur mikrochromatographischen Kontrolle der Arzneimitteleinnahme. Deutsches Gebrauchsmuster G 79046483.Google Scholar
Uihlein, M. & Fleckenstein, G. (1981) Chromatographic test-kit for the control of drug compliance. Paper presented at the XI International Congress of Clinical Chemistry, IV European Congress of Clinical Chemistry, Vienna, August 30—September 5, 1981.Google Scholar
Vereczkey, L., Bianchetti, S., Garattini, S. & Morselli, P. L. (1975) Pharmacokinetics of nomifensine in man. Psychopharmacology, 45, 225.Google Scholar
Weber, E. (1980) Patienten-Compliance. Arzt und Patient, 1, 4—9.Google Scholar
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