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A tiny RNA that catalyzes both aminoacyl-RNA and peptidyl-RNA synthesis

Published online by Cambridge University Press:  01 November 1999

MALI ILLANGASEKARE  and
MICHAEL YARUS
MALI ILLANGASEKARE
Affiliation:
Department of Molecular, Cellular, and Developmental Biology, University of Colorado, Boulder, Colorado 80309-0347, USA
MICHAEL YARUS
Affiliation:
Department of Molecular, Cellular, and Developmental Biology, University of Colorado, Boulder, Colorado 80309-0347, USA
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Abstract

A 29-nt RNA catalyst successively forms the aminoacyl ester phe-RNA, and then peptidyl-RNA (phe-phe-RNA), given phenylalanine adenylate (phe-AMP) as substrate. Catalysis of two related reactions at similar rates supports the argument that RNA catalysts would evolve as groups with similar mechanisms. In particular, successive aminoacyl- and peptidyl-RNA synthesis by one RNA suggests that uncoded but RNA-catalyzed peptide synthesis would evolve before the synthesis of coded peptides.

Keywords

acylationevolutionribozymeRNA worldtranslation
Type
REPORTS
Information
RNA , Volume 5 , Issue 11 , November 1999 , pp. 1482 - 1489
Copyright
1999 RNA Society

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