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Accepted manuscript

The application of machine perfusion for the testing of peripheral nerve and muscle interfacing for bionic prostheses: A systematic review

Published online by Cambridge University Press:  09 January 2025

Kavit R Amin Open the ORCID record for Kavit R Amin [Opens in a new window] ,
Erin R. Armstrong ,
Alexander J. Casson  and
James E. Fildes
Kavit R Amin*
Affiliation:
Department of Plastic Surgery, Manchester University NHS Foundation Trust, Manchester UK. Division of Cell Matrix, Biology and Regenerative Medicine, University of Manchester, Manchester, UK. The Pebble Institute, Manchester, UK.
Erin R. Armstrong
Affiliation:
The Pebble Institute, Manchester, UK.
Alexander J. Casson
Affiliation:
The University of Manchester, Department of Electrical and Electronic Engineering, Oxford Road, Manchester M13 9PL, UK
James E. Fildes
Affiliation:
The Pebble Institute, Manchester, UK. Healthcare Technologies Institute, University of Birmingham, Birmingham, UK.
*
Correspondence to: Dr Kavit Amin, The Pebble Institute, Manchester, UK. Email: kav.amin@pebble.bio
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Abstract

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This systematic review evaluates the use of Normothermic Machine Perfusion (NMP) as a testbed for developing peripheral nerve and muscle interfaces for bionic prostheses. Our findings suggest that NMP offers a viable alternative to traditional models, with significant implications for future research and clinical applications. A literature search was performed using Ovid MEDLINE [1946 to October 2023], revealing 559 abstracts.

No studies using nerve and/or muscle electrodes for the testing or development of bionic interface technologies were identified, except for one conference abstract. NMP could serve as a test bed for future development of interface biocompatibility, selectivity, stability, and data transfer, whilst complying with ethical practices and potentially offering greater relevance for human translation.

Type
Impact Paper
Information
Research Directions: Biotechnology Design , Accepted manuscript , pp. 1 - 19
Creative Commons
Creative Common License - CCCreative Common License - BYCreative Common License - NCCreative Common License - ND
This is an Open Access article, distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives licence (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is unaltered and is properly cited. The written permission of Cambridge University Press must be obtained for commercial re-use or in order to create a derivative work.
Copyright
© The Author(s), 2025. Published by Cambridge University Press