Hostname: page-component-65f69f4695-q7d28 Total loading time: 0 Render date: 2025-06-28T21:56:48.293Z Has data issue: false hasContentIssue false
  • English
  • Français

Schizophrenic syndromes, cognitive performance and neurological dysfunction

Published online by Cambridge University Press:  09 July 2009

Peter F. Liddle
Peter F. Liddle*
Affiliation:
Department of Psychiatry, University of Oxford
*
1Address for correspondence: Dr P. F. Liddle, Charing Cross and Westminster Medical School, Academic Unit, Horton Hospital, Long Grove Road, Epsom, Surrey KT9 8PZ.
Get access Rights & Permissions [Opens in a new window]

Synopsis

In a sample of chronic schizophrenic patients, a group of symptoms which included poverty of speech and lack of spontaneous movement was found to be associated with poor performance in tests of conceptual thinking, object naming and long-term memory, and also with cortical neurological signs. A second group of symptoms which included formal thought disorder and inappropriate affect was associated with poor performance in tests of concentration, immediate recall and word learning, and with cortical neurological signs. The findings suggest that these two syndromes are associated with dysfunction at two different sites within the frontal lobes. A third group of symptoms, comprising various delusions and hallucinations, was associated with poor figure-ground perception, and might reflect temporal lobe dysfunction.

Information

Type
Research Article
Information
Psychological Medicine , Volume 17 , Issue 1 , February 1987 , pp. 49 - 57
Copyright
Copyright © Cambridge University Press 1987

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

Article purchase

Temporarily unavailable

References

American Psychiatric Association (1980). Diagnostic and Statistical Manual for Psychiatric Disorders (third edn). APA: Washington D.C.Google Scholar
Andreasen, N. C. (1983). Comprehensive Assessment of Symptoms and History. University of Iowa College of Medicine: Iowa.Google Scholar
Andreasen, N. C. & Olsen, S. (1982). Negative v. positive schizophrenia. Archives of General Psychiatry 39, 789–794.CrossRefGoogle ScholarPubMed
Ayers, A. J. (1966). Southern California Figure-Ground Visual Perception Test. Western Psychological Services: Los Angeles.Google Scholar
Bannon, M. J. & Roth, R. H. (1983). Pharmacology of mesocortical dopamine neurons. Pharmacological Reviews 35, 53–68.Google ScholarPubMed
Blumer, D. & Benson, D. F. (1975). Personality changes with frontal lobe lesions. In Psychiatric Aspects of Neurological Disease (ed. Blumer, D and Benson, D F), pp. 151–170. Grune & Stratton: New York.Google Scholar
Clark, C. M., Kessler, R., Buchsbaum, M. S., Margolin, R. A. & Holcomb, H. H. (1984). Correlational methods for determining regional coupling of cerebral glucose metabolism: a pilot study. Biological Psychiatry 19, 663–678.Google ScholarPubMed
Crow, T. J.. (1980). Molecular pathology of schizophrenia: more than one disease process? British Medical Journal 280, 66–68.CrossRefGoogle ScholarPubMed
Crow, T. J., Johnstone, E. C. & Owen, F. (1979). Research on schizophrenia. In Recent Advances in Clinical Psychiatry Number 3 (ed. Granville-Grossman, K.), pp. 1–36Churchill Livingstone: Edinburgh.Google Scholar
Davis, J. M. (1976). Comparative doses and costs of antipsychotic medication. Archives of General Psychiatry 33, 858–861.CrossRefGoogle ScholarPubMed
Davison, K. & Bagley, C. R. (1969). Schizophrenia-like psychoses associated with organic disorders of the central nervous system: a review of the literature. In Current Problems in Neuropsychiatry: Schizophrenia, Epilepsy and the Temporal Lobe (ed. Herrington, R. N.), pp. 113–189. Headley: Ashford, Kent.Google Scholar
Dunn, L. M. (1959). Peabody Picture Vocabulary Test. American Guidance Service Inc.: Minneapolis.Google Scholar
Goldstein, G. (1978), Cognitive and perceptual differences between schizophrenics and organics. Schizophrenia Bulletin 4, 160–185.CrossRefGoogle ScholarPubMed
Goldstein, G. & Halperin, K. M. (1977). Neuropsychological differences among sub-types of schizophrenia. Journal of Abnormal Psychology 86, 34–40.CrossRefGoogle Scholar
Hamlin, R. M. (1970). Intellectual function 14 years after frontal lobe surgery. Cortex 6, 299–307.CrossRefGoogle ScholarPubMed
Kolb, B. & Wishaw, I. Q. (1980). Fundamentals of Human Neuropsychology. Freeman: San Francisco.Google Scholar
Lezak, M. D. (1976). Neuropsychological Assessment. Oxford University Press: New York.Google Scholar
Liddle, P. F. (1986). The symptoms of chronic schizophrenia: a re-examination of the positive–negative dichotomy. British Journal of Psychiatry (in the press).Google Scholar
Luria, A. R. (1980). Higher Cortical Functions in Man. Basic Books: New York.CrossRefGoogle Scholar
Magaro, P. A. (1981). The paranoid and the schizophrenic: the case for a distinct cognitive style. Schizophrenia Bulletin 7, 632–661.CrossRefGoogle ScholarPubMed
Newcombe, F. & Marshall, J. (1967). Immediate recall of sentences. Neuropsychologia 5, 329–334.CrossRefGoogle Scholar
Newcombe, F., Oldfield, R. L., Ratcliff, G. G. & Wingfield, A. (1971). Recognition and naming of object-drawings by men with focal brain wounds. Journal of Neurology, Neurosurgery and Psychiatry 34, 329–340.CrossRefGoogle ScholarPubMed
Payne, R. W. & Hewlett, J. G. H. (1960). Thought disorder in psychotic patients. In Experiments in Personality Vol. 2 (ed. Eysenck, H. J.), pp. 3–104. Routledge and Kegan Paul: London.Google Scholar
Pycock, C. J., Kerwin, R. W. & Carter, C. J. (1980). Effects of lesion of cortical dopamine terminals on sub-cortical dopamine receptors in rats. Nature (London) 286, 74–77.CrossRefGoogle Scholar
Quitkin, F., Rifkin, A. & Klein, D. F. (1976). Neurologic soft signs in schizophrenia and character disorders. Archives of General Psychiatry 33, 845–853.CrossRefGoogle ScholarPubMed
Robertson, G. & Taylor, P. J. (1985). Some cognitive correlates of schizophrenic illnesses. Psychological Medicine 15, 81–98.CrossRefGoogle ScholarPubMed
Rochford, J. M., Detre, T., Tucker, G. J. & Harrow, M. (1970). Neuropsychological impairments in functional psychiatric diseases. Archives of General Psychiatry 22, 114–119.CrossRefGoogle ScholarPubMed
Simpson, G. M. & Angus, J. W. S. (1970). A rating scale for extra-pyramidal side effects. Acta Psychiatrica Scandinavica 212, 44–51.CrossRefGoogle Scholar
Slater, E., Beard, A. W. & Glitherow, E. (1963). The schizophrenia-like psychoses of epilepsy. British Journal of Psychiatry 109, 95–105.CrossRefGoogle Scholar
Spellacy, F. T. & Spreen, O. (1969). A short form of the token test. Cortex 5, 390–397.CrossRefGoogle Scholar
Stack, J. T. & Phillips, A. G. (1970). Performance of medical, brain damaged and schizophrenic patients on the Halstead-Reitan neuropsychology battery. Newsletter for Research in Psychology 12, 16–18.Google Scholar
Stevens, M. (1979). Famous personality test: a test for remote memory. Bulletin of the British Psychological Society 32, 211–214.Google Scholar
Walsh, K. W. (1977). Neuropsychiatry: a Clinical Approach. Churchill Livingstone: Edinburgh.Google Scholar
Warrington, E. K. (1974). Deficient recognition memory in organic amnesia. Cortex 10, 289–291.CrossRefGoogle ScholarPubMed
Wechsler, D. (1958). The Measurement and Appraisal of Adult Intelligence (fourth edn). Williams and Wilkins: Baltimore.Google Scholar