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Clinical issues in the use of carbamazepine in psychiatry: a review

Published online by Cambridge University Press:  09 July 2009

Martin Elphick
Martin Elphick*
Affiliation:
Department of Clinical Psychopharmacology, Radcliffe Infirmary, Oxford
*
1Address for correspondence: Dr Martin Elphick, Radcliffe Infirmary, Woodstock Road, Oxford OX2 6HE.
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Synopsis

Evidence is presented here in support of the efficacy of carbamazepine (CBZ) in a variety of different psychiatric conditions. While there is now considerable evidence to support the use of CBZ in the acute treatment of mania and in the prophylaxis of bipolar affective disorder, particularly as a second-line drug, its usefulness in other conditions is less well documented. Overactivity, aggression and poor impulse control appear to improve in a variety of different diagnostic categories, and it may possibly be more appropriately prescribed to control or prevent these symptoms than as a treatment for a particular disease entity. The use of CBZ as an antidepressant is not well proven. Most of the adverse effects reported are due to rapid initial escalation of dosage, which can be avoided, or are reversible such as drug rashes. Severe adverse effects have been reported but are rare. Frequent monitoring of drug plasma concentration is not required. Some reports of synergism with lithium have appeared and combination therapy may be a useful strategy. Drug interactions, the need for clinical monitoring, and the possible pharmacological mode of action of CBZ are also discussed.

Type
Original Articles
Information
Psychological Medicine , Volume 19 , Issue 3 , August 1989 , pp. 591 - 604
Copyright
Copyright © Cambridge University Press 1989

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References

Andrus, P. F. (1984). Lithium and carbamazepine (letter). Journal of Clinical Psychiatry 45, 525.Google Scholar
Anton, R. F., Waid, L. R., Fossey, M. & Aubuchon, P. (1986). Case report of carbamazepine treatment of organic brain syndrome with psychotic features. Journal of Clinical Pharmacology 6, 232–234.Google ScholarPubMed
Arana, G. W., Goff, D. C., Friedman, H., Ornsteen, M. & Shader, R. I. (1986). Does carbamazepine-induced reduction of haloperidol levels worsen psychotic symptoms? American Journal of Psychiatry 143, 650–651.Google ScholarPubMed
Ballenger, J. C. & Post, R. M. (1978). Therapeutic effects of carbamazepine in affective illness: a preliminary report. Communications in Psychopharmacology 2, 159–175.Google ScholarPubMed
Ballenger, J. C. & Post, R. M. (1980). Carbamazepine (Tegretol) in manic-depressive illness: a new treatment. American Journal of Psychiatry 137, 782–790.Google ScholarPubMed
Ballenger, J. C. & Post, R. M. (1984). Carbamazepine in alcohol withdrawal syndromes and schizophrenic psychoses. Psychopharmacology Bulletin 20, 572–584.Google ScholarPubMed
Barker, W. A. & Eccleston, D. (1984). The treatment of chronic depression: an illustrative case. British Journal of Psychiatry 144, 317–319.CrossRefGoogle ScholarPubMed
Bjorkquist, S. E., Isohanni, M., Mäkalä, R. & Malinen, L (1976). Ambulant treatment of alcohol withdrawal symptoms with carbamazepine: a formal multicentre double-blind comparison with placebo. Acta Psychiatrica Scandinavica 53, 333–342.CrossRefGoogle Scholar
Brodie, M. J. (1987). Carbamazepine: pharmacokinetics and interactions. International Clinical Psychopharmacology 2 (supplement), 73–81.Google Scholar
Brooks, S. C. & Lessin, B. E. (1983). Treatment of resistant lithium-induced nephrogenic diabetes insipidus and schizo-affective psychosis with carbamazepine. American Journal of Psychiatry 140, 1077–1078.Google ScholarPubMed
Buck, O. D. & Havey, P. (1986). Combined carbamazepine and lithium therapy for violent behaviour. (Letter.) American Journal of Psychiatry 143, 1487.Google Scholar
Byrne, E., Wong, C. H., Chambers, D. G. & Rice, J. P. (1979). Carbamazepine therapy complicated by nodal bradycardia and water intoxication. Australian and New Zealand Journal of Medicine 9, 295–296.CrossRefGoogle ScholarPubMed
Cantor, C. (1986). Carbamazepine and ECT: a paradoxical combination. (Letter.) Journal of Clincial Psychology 47, 276–277.Google Scholar
Chaudhry, R. P. & Waters, B. G. (1983). Lithium and carbamazepine interaction: possible neurotoxicity. Journal of Clinical Psychiatry 44, 30–31.Google ScholarPubMed
Cookson, J. C. (1987). Carbamazepine in acute mania. International Clinical Psychopharmacology 2, (suppl. 1), 11–22.Google Scholar
Dalby, M A. (1971). Anti-epileptic and psychotropic effect of carbamazepine (Tegretol) in the treatment of psychomotor epilepsy. Epilepsia 12, 325–334.CrossRefGoogle ScholarPubMed
De Vogelaer, J (1981). Carbamazepine in the treatment of psychiatric and behavioural disorders. A pilot study. Acta Psychiatrica Belgica 81, 532–541.Google Scholar
Elphick, M. (1985). An open clinical trial of carbamazepine in treatment-resistant bipolar and schizo-affective psychotics. British Journal of Psychiatry 147, 198–200.CrossRefGoogle ScholarPubMed
Elphick, M. (1988 a). The clinical uses and pharmacology of carbamazepine in psychiatry. International Clinical Psychopharmacology (in the press).CrossRefGoogle Scholar
Elphick, M. (1988 b). The effects of carbamazepine on dopamine function in rodents. Psychopharmacology (in the press).CrossRefGoogle Scholar
Elphick, M., Lyons, F. & Cowen, P. J. (1988). Low tolerability of carbamazepine in psychiatric patients may restrict its clinical usefulness. Journal of Psychopharmacology 2, 1–4.CrossRefGoogle ScholarPubMed
Elphick, M., Anderson, S., Hallis, K. & Grahame-Smith, D. G. (1989). The effects of carbamazepine on 5 hydroxytryptamine function in rodents. Psychopharmacology (in the press).CrossRefGoogle Scholar
Emrich, H. M., Dose, M. & Von Zerssen, D. (1985). The use of sodium valproate, carbamazepine and oxcarbazepine in patients with affective disorders. Journal of Affective Disorders 8, 243–250.CrossRefGoogle ScholarPubMed
Essa, M. (1986). Carbamazepine in dementia. Journal of Clinical Psychopharmacology 6, 234–236.Google Scholar
Fast, D. K., Jones, B. D., Kusalic, M. & Erickson, M. (1986). Effect of carbamazepine on neuroleptic levels and efficacy (letter). American Journal of Psychiatry 143, 117–118.CrossRefGoogle Scholar
Fawcett, J. & Kravitz, H. M. (1985). The long-term management of bipolar disorders with lithium, carbamazepine, and anti-depressants. Journal of Clinical Psychopharmacology 46, 58–60.Google Scholar
Fawcett, R. G. (1987). Erythema multiforme major in a patient treated with carbamazepine. Journal of Clinical Psychiatry 48, 416–417.Google Scholar
Folks, D. G., King, L. D., Dowdy, S. B., Petrie, W. M., Jack, R. A., Koomen, J. C., Swenson, B. R. & Edwards, P. (1982). Carbamazepine treatment of selected affectively disordered inpatients American Journal of Psychiatry 139, 115–117.Google ScholarPubMed
Fredholm, B. B. & Dunwiddie, T. V. (1988). How does adenosine inhibit transmitter release? Trends in Pharmacological Sciences 9, 130–134.Google Scholar
Frigerio, A. & Morselli, P. L. (1975). Carbamazepine: Biotrans-formation: In Complex Partial Seizures and Their Treatment, (ed. Penry, J. and Daly, D. D.), pp. 295–308. Advances in Neurology vol. 11. Raven Press: New York.Google Scholar
Gardner, D. L. & Cowdry, R. W. (1986 a). Positive effects of carbamazepine on behavioural dyscontrol in borderline personality disorder. American Journal of Psychiatry 143, 519–522.Google ScholarPubMed
Gardner, D. L. & Cowdry, R. W. (1986 b). Development of melancholia during carbamazepine treatment in borderline personality disorder. Journal of Clinical Pharmacology 6, 236–239.Google ScholarPubMed
Gerson, W. T., Fine, D. G., Speilberg, S. P. & Sensenbrenner, L. L. (1983). Anti-convulsant-induced aplastic anaemia: increased susceptibility to toxic drug metabolites in vitro. Blood 61, 889–1893CrossRefGoogle ScholarPubMed
Ghose, K. (1980). Interaction between lithium and carbamazepine (letter). British Medical Journal 280, 1122.CrossRefGoogle Scholar
Greenberg, W. M. (1986). Sedative or anti-manic effects of carbamazepine and treatment of behavioural dyscontrol (letter). American Journal of Psychiatry 143, 1486–1487.Google ScholarPubMed
Grossi, E., Sacchetti, E., Vita, A., Conte, G., Favavelli, C., Hautman, G., Zerbi, D., Mesina, A. M., Drago, F. & Motta, A. (1984). Carbamazepine vs chloropromazine in mania: a double-blind trial. In Anticonvulsants in Affective Disorders (ed. Emrich, H. M.Okuma, T. and Muller, A. A.), pp. 177–187. Excerpta Medica: Amsterdam.Google Scholar
Gupta, B. K., Fish, D. N. & Yerevanian, B. I. (1987). Carbamazepine for intermittent explosive disorder in a Prader-Willi syndrome patient (letter). Journal of Clinical Psychiatry 48, 423.Google Scholar
Hakola, H. P. A. & Laulumaa, , (1982). Carbamazepine in the treatment of violent schizophrenics. Lancet i, 1358.CrossRefGoogle Scholar
Hart, R. G. & Easton, R. (1982). Carbamazepine and haematological monitoring. Annals of Neurology 11, 309–312.CrossRefGoogle Scholar
Hellekson, L., Buckland, R. & Price, T. (1979). Organic personality disturbance: a case of apparently atypical cyclic affective disorder. American Journal of Psychiatry 136, 833–835.Google Scholar
Inoue, K., Arima, S., Tanaka, K., Fukui, Y. & Kato, N. (1981). A lithium and carbamazepine combination in the treatment of bipolar disorder – a preliminary report. Folia Psychiatrica et Neurologica Japonica 35, 465–475.Google ScholarPubMed
Jann, M. W., Ereshefsky, L., Saklad, S. R., Seidel, D. R., David, C. M., Burch, N. R. & Bowden, C. L. (1985). Effect of carbamazepine on plasma haloperidol levels. Journal of Clinical Psychopharmacology 5, 106–109.CrossRefGoogle ScholarPubMed
Jenike, M A. & Brotman, A. W. (1984). The EEG in obsessive-compulsive disorder. Journal of Clinical Psychiatry 45, 122–124.Google ScholarPubMed
Joffe, R. T. & Swinson, R. P. (1987). Carbamazepine in obsessive-compulsive disorders. Biological Psychiatry 22, 1169–1171.CrossRefGoogle Scholar
Joffe, R. T., Post, R. M. & Uhde, T. W. (1985 a) Lack of pharmacokinetic interaction of carbamazepine with tranylcypromine (letter). Archives of General Psychiatry 42, 738CrossRefGoogle Scholar
Joffe, R. T., Post, R. M., Roy-Byrne, P. P. & Uhde, T. W. (1985 b). Haematological effects of carbamazepine in illness. American Journal of Psychiatry 142, 1196–1199.Google ScholarPubMed
Joffe, R. T., Post, R. M. & Uhde, T. W. (1986 a). Effects of carbamazepine on serum electrolytes in affectively ill patients. Psychological Medicine 16, 331–335.CrossRefGoogle ScholarPubMed
Joffe, R. T., Post, R. M. & Uhde, T. W. (1986 b). Effect of carbamazepine on body weight in affectively ill patients. Journal of Clinical Psychiatry 47, 313–314.Google Scholar
Joyce, P. (1987). In discussion at a meeting entitled ‘Carbamazepine in Affective Disorders’. International Clinical Psychopharmacology 2, supplement 1, 87.Google Scholar
Joyce, R. P. & Gunderson, C. H. (1980). A carbamazepine-induced orofacial dyskinesia. Neurology 30, 1333–1334.CrossRefGoogle ScholarPubMed
Juergens, S. M., Milliner, D. S. & Lee, M. E. (1986). Carbamazepine and hyponatraemia (letter). American Journal of Psychiatry 143, 1328–1329.Google Scholar
Kanter, G. L., Yerevanian, B. I. & Ciccone, J. R. (1984). Case report of a possible interaction between neuroleptics and carbamazepine. American Journal of Psychiatry 141, 1101–1102.Google ScholarPubMed
Kaplan, A. S., Garfinkel, P. E., Darby, P. L. & Gardner, D. M. (1983). Carbamazepine in the treatment of bulimia. American Journal of Psychiatry 140, 1225–1226.Google ScholarPubMed
Kidron, R., Averbuch, I., Klein, E. & Belmaker, R. H. (1986). Carbamazepine-induced reduction of blood levels of haloperidol in chronic schizophrenia. Biological Psychiatry 20, 219–222.CrossRefGoogle Scholar
Kishimoto, A. (1984). A follow-up prophylactic study of carbamazepine in affective disorders. In Anticonvulsants in Affective Disorders (ed. Emrich, H. M.Okuma, T., and Muller, A. A.), pp. 88–92. Excerpta Medica: Amsterdam.Google Scholar
Klein, E., Bental, E., Lerer, B. & Belmaker, R. H. (1984). Carbamazepine and haloperidol v. placebo and haloperidol in excited psychoses. Archives of General Psychiatry 41, 165–170.CrossRefGoogle ScholarPubMed
Klein, E., Uhde, T. W. & Post, R. M. (1986). Preliminary evidence for the utility of carbamazepine in alprazolam withdrawal. American Journal of Psychiatry 143, 235–236.Google ScholarPubMed
Laker, M. B. (1985). Hyponatraemia during carbamazepine therapy. Clinical Pharmacology and Therapeutics 37, 693–696.Google Scholar
Lawlor, B. A. (1987). Carbamazepine, alprazolam withdrawal, and panic disorder (letter). American Journal of Psychiatry 144, 265–266.CrossRefGoogle Scholar
Lerer, B. (1985). Alternative therapies for bipolar disorder. Journal of Clinical Psychiatry 46, 309–316.Google ScholarPubMed
Lerer, B., Moore, N., Meyendorff, E., Cho, S. R. & Gershon, S. (1987). Carbamazepine versus lithium in mania: a double-blind study. Journal of Clinical Psychiatry 48, 89–93.Google Scholar
Lipinski, J. F. & Pope, H. G. (1982). Possible synergistic action between carbamazepine and lithium carbonate in the treatment of three acutely manic patients. American Journal of Psychiatry 139, 948–949.Google Scholar
Lipper, S., Davidson, J. R., Grady, T. A., Edinger, J. D., Hammett, E. B., Mahorney, S. L. & Cavenor, J. O. (1986). Preliminary study of carbamazepine in post-traumatic stress disorders. Psychosomatics 27, 849–854.CrossRefGoogle Scholar
Luchins, D. J. (1984). Carbamazepine in violent non-epileptic schizophrenics. Psychopharmacology Bulletin 20, 569–571.Google ScholarPubMed
Lusznat, R. M., Murphy, D. P. & Nunn, C. M. H. (1987). Carbamazepine in the prophylaxis of bipolar affective disorders. International Clinical Psychopharmacology 2, (supplement 1), 37–42.Google Scholar
McAllister, T. W. (1985). Carbamazepine in mixed frontal lobe and psychiatric disorders. Journal of Clinical Psychiatry 46, 393–394.Google Scholar
Marangos, P. J., Post, R. H., Patel, J., Zander, K., Parma, A. & Weiss, S. (1983). Specific and potent interactions of carbamazepine with brain adenosine receptors. European Journal of Pharmacology 93, 175–182.Google Scholar
Marangos, P. J., Patel, J., Smith, K. D. & Post, R. M. (1987). Adenosine antagonist properties of carbamazepine. Epilepsia 28, 387–394.CrossRefGoogle ScholarPubMed
Nakane, Y., Okuma, T., Takahashi, R., Sato, Y., Wada, T., Sato, T., Fukushima, Y., Kumashiro, H., Ono, T., Takahashi, T., Aoki, Y., Kazamatsuri, H., Inami, M., Komai, S., Seino, M., Miyakoshi, M., Tanimara, T., Hazama, H., Kawahara, R., Otsuki, S., Hosokawa, K., Inanaga, K., Nakazawa, T. & Yamamoto, K. (1980). Multi-institutional study on the teratogenicity and fetal toxicity of anti-epileptic drugs: report of a collaborative study group in Japan. Epilepsia 21, 663–680.CrossRefGoogle Scholar
Naylor, G. J. (1985). Reversal of vanadate-induced inhibition of Na-K-ATPase. A possible explanation of the therapeutic effect of carbamazepine in affective illness. Journal of Affective Disorders 8, 91–93.CrossRefGoogle ScholarPubMed
Neppe, V. M. (1982). Carbamazepine in the psychiatric patient. Lancet ii, 334.Google Scholar
Neumann, J., Seidel, K. & Wunderlich, H. P. (1984). Comparative studies in the effect of carbamazepine and trimipramine in depression. In Anti-convulsants in Affective Disorders (ed. Emrich, H. M.Okuma, T. and Muller, A. A.), pp. 160–166. Excerpta Medica, International Congress Series, No. 626. Elsevier: Amsterdam.Google Scholar
Nidely, J. R., Blake, D. A., Freeman, J. M. & Luff, R. D. (1979). Carbamazepine levels in pregnancy and lactation. Obstetrics and Gynaecology 53, 139–140.Google Scholar
Nolen, W. A. (1983). Carbamazepine, a possible adjunct or alternative to lithium in bipolar disorder. Acta Psychiatrica Scandinavica, 67, 218–225.CrossRefGoogle ScholarPubMed
Okuma, T. (1987). Acute and prophylactic properties of carbamazepine in bipolar affective disorders. Presented at a meeting on ‘New Directions in Affective Disorders’, Jerusalem, Abstract No. S1.Google Scholar
Okuma, T., Kishimoto, A. & Inoue, K. (1973). Anti-manic and prophylactic effects of carbamazepine (Tegretol) on manic depressive psychosis. A preliminary report. Folia Psychiatrica et Neurologica Japonica 27, 283–297.Google ScholarPubMed
Okuma, T., Kishimoto, A. & Inoue, K. (1975). Anti-manic and prophylactic effects of carbamazepine (Tegretol) on manic depressive psychosis. Seishin-igaku 17, 617–630.Google Scholar
Okuma, T., Inanaga, K., Otsuki, S., Sarai, K., Takahashi, R., Hazama, H., Mori, A. & Watanabe, M. (1979). Comparison of the anti-manic efficacy of carbamazepine and chlorpromazine: a double-blind controlled study. Psychopharmacology 66, 211–217.CrossRefGoogle Scholar
Okuma, T., Inanaga, K., Otsuki, S., Sarai, K., Takahashi, R., Hazama, H., Mori, A. & Watanabe, M. (1981). A preliminary double-blind study of the efficacy of carbamazepine in prophylaxis of manic-depressive illness. Psychopharmacology 73, 95–96.CrossRefGoogle ScholarPubMed
Perényi, A. & Sztaniszlav, D. (1985). Carbamazepine in tardive dyskinesia. Psychopharmacology Bulletin 21, 345–346.Google Scholar
Perucca, E., Garratt, A., Hebdige, S. & Richens, A. (1978). Water intoxication in epileptic patients receiving carbamazepine. Journal of Neurology, Neurosurgery and Psychiatry 41, 713–718.CrossRefGoogle ScholarPubMed
Placidi, G. F., Lenzi, A., Lazzerini, F., Cassano, G. B. & Akiskal, H. S. (1986). The comparative efficacy and safety of carbamazepine versus lithium: a randomised, double-blind three-year trial in 83 patients. Journal of Clinical Psychiatry 47, 490–494.Google Scholar
Post, R. M. (1986). In reply to a letter by Madakasira, S. Carbamazepine for treatment resistant depressions? American Journal of Psychiatry 143, 131–1311.Google Scholar
Post, R. M. & Uhde, T. W. (1986). Anti-convulsants in non-epileptic psychosis. In Aspects of Epilepsy and Psychiatry (ed. Trimble, M. R. and Bolwig, T. G.), pp. 177–212. J. Wiley & Sons: Chichester.Google Scholar
Post, R. M. & Weiss, S. R. B. (1987). Behavioural pharmacology of carbamazepine: differential effects on kindling. International Clinical Pharmacology 2, 51–72.Google Scholar
Post, R. M., Uhde, T. W., Ballenger, J. C., Chatterji, D. C., Greene, R. F. & Bunney, W. E. (1983). Carbamazepine and its 10, 11-epoxide metabolite in plasma and CSF. Archives of General Psychiatry 40, 673–676.CrossRefGoogle ScholarPubMed
Post, R. M., Uhde, T. W., Roy-Byrne, P. P. & Joffe, R. T. (1986). Anti-depressant effects of carbamazepine. American Journal of Psychiatry 143, 29–34.Google Scholar
Post, R. M., Uhde, T. W., Rubinow, D. R. & Huggins, T. (1987 a). Differential time course of anti-depressant effects after sleep deprivation, EEG, and carbamazepine: clinical and theoretical implications. Psychiatric Research 22, 11–19.CrossRefGoogle Scholar
Post, R. M., Uhde, T. W., Roy-Byrne, P. P. & Joffe, R. T. (1987 b). Correlates of anti-manic response to carbamazepine. Psychiatry Research 21, 71–83.CrossRefGoogle Scholar
Pynnönen, S. (1979). Pharmacokinetics of carbamazepine in man: a review. Therapeutic Drug Monitoring 1, 409–431.Google Scholar
Rankel, H. W. & Rankel, L. E. (1988). Carbamazepine in the treatment of catatonia. American Journal of Psychiatry 145, 361–362.Google ScholarPubMed
Regan, W. M. (1987). Successful treatment course with carbamazepine despite initial significant leukopoenia: case report. Journal of Clinical Psychiatry 48, 338–339.Google Scholar
Reid, A. H., Naylor, C. J. & Kay, D. S. (1981). A double-blind, placebo-controlled crossover trial of carbamazepine in overactive, severely mentally handicapped patients. Psychological Medicine 11, 109–113.CrossRefGoogle ScholarPubMed
Reynolds, J. E. F. (1982). (ed.). Martindale: The Extra Pharmacopoeia. The Pharmaceutical Press: London.Google Scholar
Robertson, M. M. (1987). Carbamazepine and depression. International Clinical Psychopharmacology 2, (supplement 1), 23–35.Google Scholar
Roy-Byrne, P., Uhde, T. W., Post, R. M. & Joffe, R. T. (1984). Relationship of response to sleep deprivation and carbamazepine in depressed patients. Acta Psychiatrica Scandinavica 69, 379–382.CrossRefGoogle ScholarPubMed
Schaffer, C. B., Mungas, D. & Rockwell, E. (1985). Successful treatment of psychotic depression with carbamazepine. Journal of Clinical Psychopharmacology 5, 233–235.CrossRefGoogle ScholarPubMed
Schneider, H. (1975). Carbamazepine: the influence of other antiepileptic drugs on its serum level. In Clinical Pharmacology of Antiepileptic Drugs, (ed. Schneider, H.Janz, D.Gardner-Thorpe, C.Meinardi, H. and Sherwin, A. L.), pp. 189–196. Springer-Verlag: BerlinCrossRefGoogle Scholar
Schou, M., Goldfield, M. D., Weinstein, M. R. & Willeneuve, A. (1973). Lithium and pregnancy. I. Report from the register of lithium babies. British Medical Journal ii, 135–136.Google Scholar
Sillanpaa, M. (1981). Carbamazepine. Pharmacology and clinical uses. Acta Neurologica Scandinavica. Suppl. 88.Google Scholar
Shukla, S., Godwin, C. D., Long, L. E. & Miller, M. C. (1984). Lithium-carbamazepine neurotoxicity and risk factors. American Journal of Psychiatry 141, 1604–1606.Google ScholarPubMed
Shukla, S., Cook, B. L. & Miller, M. G. (1985). Lithium-carbamazepine versus lithium-neuroleptic prophylaxis in bipolar illness. Journal of Affective Disorders 9, 219–222.CrossRefGoogle ScholarPubMed
Sorensen, P. S. & Hammer, M. (1984). Effects of long-term carbamazepine treatment on water metabolism and plasma vasopressin concentration. European Journal of Clinical Pharmacology 26, 719–722.CrossRefGoogle Scholar
Stewart, J. T. (1985). Carbamazepine treatment of a patient with Kluver-Bucy syndrome. Journal of Clinical Psychiatry 46, 496–497.Google Scholar
Stoll, K. D., Bisson, H. E. & Fischer, E. (1985). Carbamazepine versus haloperidol in manic syndrome – first report of a multicentric study in Germany. In Biological Psychiatry (ed. Shagass, C.), pp. 127–134. Elsevier: New York.Google Scholar
Stone, J. L., McDaniel, K. D., Hughes, J. R. & Hermann, B. P. (1986). Episodic dyscontrol disorders and paroxysmal EEG abnormalities: successful treatment with carbamazepine. Biological Psychiatry 21, 208–212.CrossRefGoogle ScholarPubMed
Takezaki, H. & Hanaoka, M. (1971). The use of carbamazepine in the control of manic-depressive psychosis and other states. Clinical Psychiatry 13, 173–183.Google Scholar
Tomson, T., & Bertilsson, L. (1984). Potential therapeutic effect of carbamazepine 10, 11-epoxide in trigeminal neuralgia. Archives of Neurology 41, 598–604.Google Scholar
Trimble, M. R. (1987 a). Antiepileptic and psychotropic properties of carbamazepine. International Clinical Psychopharmacology 2, suppl. 1, 1–9.Google Scholar
Trimble, M. R. (1987 b). Discussion at a meeting on carbamazepine in affective disorders. International Clinical Psychopharmacology 2, suppl. 1, 43–49.Google Scholar
Tunks, E. R & Dermer, S. W. (1977). Carbamazepine in the dyscontrol syndrome associated with limbic system dysfunctions. Journal of Nervous and Mental Diseases 164, 56–63.CrossRefGoogle Scholar
Uhde, T. W. & Post, R. M. (1983). Effect of carbamazepine on serum electrolytes: clinical and theoretical implications. Journal of Clinical Psychopharmacology and Therapy 3, 103–106.Google Scholar
Vieweg, V., Glick, J. L., Herring, S., Kerler, R., Godleski, L. S., Barber, J., Yank, G. & Spradlin, W. (1987). Absence of carbamazepine-induced hyponatraemia among patients also given lithium. American Journal of Psychiatry 144, 943–947.Google ScholarPubMed
Watkins, S. E., Callender, K., Thomas, D. R., Tidmarsh, S. F. & Shaw, D. M. (1987). The effect of carbamazepine and lithium on remission from affective illness. British Journal of Psychiatry 150, 180–182.Google Scholar
Wetterling, T. (1987). Open clinical trial of carbamazepine in chronic schizophrenic inpatients. Pharmacopsychiatry 20, 127–130.CrossRefGoogle ScholarPubMed
Wickham, E. A. & Reed, J. V. (1987). Lithium for the control of aggressive and self-mutilating behaviour. International Clinical Psychopharmacology 2, 181–190.Google Scholar
Willow, M. & Catterall, W. A. (1982). Inhibition of binding of [3H]batrachotoxin A 20-α-benzoate to sodium channels by the anti-convulsant drugs diphenylhydantoin and carbamazepine. Molecular Pharmacology 20, 627–637.Google Scholar
Wolf, M. E., Alavi, A. & Mosnaim, A. D. (1988). Post-traumatic stress disorder in Vietnam veterans. Clinical and EEG findings; possible therapeutic effects of carbamazepine. Biological Psychiatry 23, 642–644.CrossRefGoogle ScholarPubMed
Wood, A. J., Elphick, M. & Grahame-Smith, D. G. (1987) Chronic lithium, carbamazepine and haloperidol, but not phenytoin stimulate 86Rb uptake by mouse brain P2 fractions. British Journal of Pharmacology 92, proc. suppl. 579.Google Scholar
Yassa, R., Iskander, H., Nastase, C. & Camille, Y. (1988). Carbamazepine and hyponatraemia in patients with affective disorders. American Journal of Psychiatry 145, 339–342.Google Scholar
Yerevanian, B. I. & Hodgman, C. H. (1985). A haloperidol-carbamazepine interaction in a patient with rapid-cycling bipolar disorder (letter). American Journal of Psychiatry 142, 785–786.Google Scholar
Zakrzewska, J. M. & Ivanyi, L. (1988). In vitro lymphocyte proliferation by carbamazepine, carbamazepine-10, 11-epoxide and oxcarbazepine in the diagnosis of drug-induced hypersensitivity. Journal of Allergy and Immunology 82, 110–115.CrossRefGoogle ScholarPubMed