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Abnormal resting-state effective connectivity in large-scale networks among obsessive-compulsive disorder

Published online by Cambridge University Press:  13 June 2023

Yinhuan Xu ,
Shaoqiang Han ,
Yarui Wei ,
Ruiping Zheng ,
Jingliang Cheng  and
Yan Zhang
Yinhuan Xu
Affiliation:
Department of Magnetic Resonance Imaging, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, China; Key Laboratory for Functional Magnetic Resonance Imaging of Henan Province, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, China; Engineering Research Center of Medical Imaging Intelligent Diagnosis and Treatment of Henan Province, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, China; Key Laboratory of Brain Function and Cognitive Magnetic Resonance Imaging of Zhengzhou, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, China; Key Laboratory of Magnetic Resonance and Brain Function of Henan Province, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, China; Key Laboratory of Imaging Intelligence Research Medicine of Henan Province, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, China and Engineering Technology Research Center for Detection and Application of Brain Function of Henan Province, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, China
Shaoqiang Han
Affiliation:
Department of Magnetic Resonance Imaging, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, China; Key Laboratory for Functional Magnetic Resonance Imaging of Henan Province, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, China; Engineering Research Center of Medical Imaging Intelligent Diagnosis and Treatment of Henan Province, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, China; Key Laboratory of Brain Function and Cognitive Magnetic Resonance Imaging of Zhengzhou, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, China; Key Laboratory of Magnetic Resonance and Brain Function of Henan Province, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, China; Key Laboratory of Imaging Intelligence Research Medicine of Henan Province, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, China and Engineering Technology Research Center for Detection and Application of Brain Function of Henan Province, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, China
Yarui Wei
Affiliation:
Department of Magnetic Resonance Imaging, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, China; Key Laboratory for Functional Magnetic Resonance Imaging of Henan Province, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, China; Engineering Research Center of Medical Imaging Intelligent Diagnosis and Treatment of Henan Province, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, China; Key Laboratory of Brain Function and Cognitive Magnetic Resonance Imaging of Zhengzhou, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, China; Key Laboratory of Magnetic Resonance and Brain Function of Henan Province, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, China; Key Laboratory of Imaging Intelligence Research Medicine of Henan Province, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, China and Engineering Technology Research Center for Detection and Application of Brain Function of Henan Province, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, China
Ruiping Zheng
Affiliation:
Department of Magnetic Resonance Imaging, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, China; Key Laboratory for Functional Magnetic Resonance Imaging of Henan Province, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, China; Engineering Research Center of Medical Imaging Intelligent Diagnosis and Treatment of Henan Province, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, China; Key Laboratory of Brain Function and Cognitive Magnetic Resonance Imaging of Zhengzhou, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, China; Key Laboratory of Magnetic Resonance and Brain Function of Henan Province, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, China; Key Laboratory of Imaging Intelligence Research Medicine of Henan Province, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, China and Engineering Technology Research Center for Detection and Application of Brain Function of Henan Province, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, China
Jingliang Cheng
Affiliation:
Department of Magnetic Resonance Imaging, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, China; Key Laboratory for Functional Magnetic Resonance Imaging of Henan Province, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, China; Engineering Research Center of Medical Imaging Intelligent Diagnosis and Treatment of Henan Province, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, China; Key Laboratory of Brain Function and Cognitive Magnetic Resonance Imaging of Zhengzhou, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, China; Key Laboratory of Magnetic Resonance and Brain Function of Henan Province, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, China; Key Laboratory of Imaging Intelligence Research Medicine of Henan Province, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, China and Engineering Technology Research Center for Detection and Application of Brain Function of Henan Province, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, China
Yan Zhang*
Affiliation:
Department of Magnetic Resonance Imaging, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, China; Key Laboratory for Functional Magnetic Resonance Imaging of Henan Province, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, China; Engineering Research Center of Medical Imaging Intelligent Diagnosis and Treatment of Henan Province, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, China; Key Laboratory of Brain Function and Cognitive Magnetic Resonance Imaging of Zhengzhou, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, China; Key Laboratory of Magnetic Resonance and Brain Function of Henan Province, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, China; Key Laboratory of Imaging Intelligence Research Medicine of Henan Province, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, China and Engineering Technology Research Center for Detection and Application of Brain Function of Henan Province, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, China
*
Corresponding author: Yan Zhang; Email: fcczhangy61@zzu.edu.cn
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Abstract

Background

Obsessive-compulsive disorder (OCD) is a chronic mental illness characterized by abnormal functional connectivity among distributed brain regions. Previous studies have primarily focused on undirected functional connectivity and rarely reported from network perspective.

Methods

To better understand between or within-network connectivities of OCD, effective connectivity (EC) of a large-scale network is assessed by spectral dynamic causal modeling with eight key regions of interests from default mode (DMN), salience (SN), frontoparietal (FPN) and cerebellum networks, based on large sample size including 100 OCD patients and 120 healthy controls (HCs). Parametric empirical Bayes (PEB) framework was used to identify the difference between the two groups. We further analyzed the relationship between connections and Yale-Brown Obsessive Compulsive Scale (Y-BOCS).

Results

OCD and HCs shared some similarities of inter- and intra-network patterns in the resting state. Relative to HCs, patients showed increased ECs from left anterior insula (LAI) to medial prefrontal cortex, right anterior insula (RAI) to left dorsolateral prefrontal cortex (L-DLPFC), right dorsolateral prefrontal cortex (R-DLPFC) to cerebellum anterior lobe (CA), CA to posterior cingulate cortex (PCC) and to anterior cingulate cortex (ACC). Moreover, weaker from LAI to L-DLPFC, RAI to ACC, and the self-connection of R-DLPFC. Connections from ACC to CA and from L-DLPFC to PCC were positively correlated with compulsion and obsession scores (r = 0.209, p = 0.037; r = 0.199, p = 0.047, uncorrected).

Conclusions

Our study revealed dysregulation among DMN, SN, FPN, and cerebellum in OCD, emphasizing the role of these four networks in achieving top-down control for goal-directed behavior. There existed a top-down disruption among these networks, constituting the pathophysiological and clinical basis.

Keywords

obsessive compulsive disordereffective connectivitydynamic causal modelling (DCM)parametric empirical Bayes (PEB)

Information

Type
Original Article
Information
Psychological Medicine , Volume 54 , Issue 2 , January 2024 , pp. 350 - 358
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Copyright
Copyright © The Author(s), 2023. Published by Cambridge University Press

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Footnotes

†

All authors shared the institutions.

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