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Unsaturated fatty acids

Published online by Cambridge University Press:  28 February 2007

Helen M. Roche
Helen M. Roche*
Affiliation:
Unit of Nutrition and Dietetics, Trinity Centre for Health Sciences, St James's Hospital, James's Street, Dublin 8, Republic of Ireland
*
Corresponding author: Dr Helen Roche, fax +353 1 4542043, email hmroche@tcd.ie
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Abstract

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There is good scientific evidence that dietary fatty acid composition is involved in the aetiology of many diseases. Increasing the supply of n−3 polyunsaturated fatty acids (PUFA) may reduce the risk of CHD. Several scientific organizations (for example, see Department of Health, 1991, 1994; British Nutrition Foundation, 1992; Scientific Committee for Food, 1993; Food and Agriculture Organization/World Health Organization, 1998) have made recommendations for n−3 PUFA; however, there is a high degree of variation both in terms of the type and amount of n−3 PUFA (up to 7-fold). This variation reflects the different scientific axioms which underlie the different recommendations. Optimal nutrition may be defined in terms of the level of a nutrient required to avoid deficiency, or the amount required to have an effect on biomarkers and functional indicators of nutrient intake, or the level of a nutrient which prevents disease. Functional biomarkers of n−3 PUFA include plasma, platelet and erythrocyte phospholipid-n−3 PUFA levels. Plasma triacylglycerol concentrations represent a functional indicator of n−3 PUFA because n−3 PUFA exert a consistent hypotriacylglycerolaemic effect which is dose-dependent and persistent. In terms of disease status, epidemiological studies have demonstrated that the incidence of CHD is inversely associated with consumption of n−3 PUFA. Despite the health benefits of n−3 PUFA, the mean daily intake falls far short of most of the recommendations. Increasing fish intake is the most obvious way to increase n−3 PUFA intake. However, a large percentage (up to 65) of the population do not eat fish. Thus, there is a need for alternative sources of n−3 PUFA, such as functional foods, whose unique fatty acid composition could fortify staple foods thereby promoting optimal levels of n−3 PUFA intake.

Keywords

Dietary fatn−3 PUFATriacylglycerolCoronary heart disease
Type
‘Optimal nutrition’
Information
Proceedings of the Nutrition Society , Volume 58 , Issue 2 , May 1999 , pp. 397 - 401
Copyright
Copyright © The Nutrition Society 1999

References

Ågren, JJ, Hanninen, O, Hanninen, A & Seppanen, K (1990) Dose responses in platelet fatty acid composition, aggregation and prostanoid metabolism during moderate freshwater fish diet. Thrombosis Research 57, 565–575.CrossRefGoogle ScholarPubMed
Anderson, LF, Solvoll, K & Drevon, CA (1996) Very-long-chain n−3 fatty acids as biomarkers for intake of fish and n−3 fatty acid concentrates. American Journal of Clinical Nutrition 64, 305–311.CrossRefGoogle Scholar
Bang, HO & Dyerberg, J (1972) Plasma lipids and lipoproteins in Greenlandic West-coast Eskimos. Acta Medica Scandinavica 192, 85–94.Google Scholar
Blonk, MC, Bilo, HJG, Nauta, JJP, Popp-Snijders, C, Mulder, C & Donker, AJM (1990) Dose-response effects of fish-oil supplementation in healthy volunteers. American Journal of Clinical Nutrition 52, 120–127.CrossRefGoogle ScholarPubMed
British Nutrition Foundation (1992) Recommendations for intakes of unsaturated fatty acids. Unsaturated Fatty Acids: Nutritional and Physiological Significance. The Report of the British Nutrition Foundation's Task Force, pp. 152–163. London: Chapman & Hall.CrossRefGoogle Scholar
Burr, ML, Fehily, AM, Gilbert, JF, Rogers, S, Holliday, RM, Sweetnam, PM, Elwood, PC & Deadman, NM (1989) Effects of changes in fat, fish, and fibre intakes on death and myocardial reinfarction: diet and reinfarction trial (DART). Lancet ii, 757–761.CrossRefGoogle Scholar
de Lorgeril, M, Renaud, S, Mamelle, N, Salen, P, Martin, J-L, Monjaud, I, Guidollet, J, Touboul, P & Delaye, J (1994) Mediterranean alpha-linolenic acid rich diet in secondary prevention of coronary heart disease. Lancet 343, 1454–1459.CrossRefGoogle ScholarPubMed
Department of Health (1991) Dietary Reference Values for Food Energy and Nutrients for the United Kingdom. Report on Health and Social Subjects no. 41. London: H.M. Stationery Office.Google Scholar
Department of Health (1994) Diet and risk. Nutritional Aspects of Cardiovascular Disease. Report on Health and Social Subjects no. 46, pp. 123–144. London: H.M. Stationery Office.Google Scholar
Endres, S, Ghorbani, R, Kelley, VE, Georgilis, K, Lonnemann, G, van der Meer, JWM, Cannon, JG, Rogers, TS, Klempner, MS, Weber, PC, Schaefer, EJ, Wolff, SM & Dinarello, CA (1989) The effect of dietary supplementation with n−3 polyunsaturated fatty acids on the synthesis of interleukin-1 and tumor necrosis factor by mononuclear cells. New England Journal of Medicine 320, 265–271.Google Scholar
Food and Agriculture Organization/World Health Organization (1998) General conclusions and recommendations of the consultation. Expert Consultation on Fats and Oils in Human Nutrition, pp. 3–9. Rome: FAO.Google Scholar
Freese, R & Mutanen, M (1997) α-Linolenic acid and marine long-chain n−3 fatty acids differ only slightly in their effects on hemostatic factors in healthy subjects. American Journal of Clinical Nutrition 66, 591–598.Google Scholar
Gregory, J, Foster, K, Tyler, H & Wiseman, M (1990) The Dietary and Nutritional Survey of British Adults. London: H.M. Stationery Office.Google Scholar
Harris, WS (1996) n−3 Fatty acids and lipoproteins: Comparison of results from human and animal studies. Lipids 31, 243–252.Google Scholar
Hirai, A, Hamazaki, T, Terano, T, Nishikawa, T, Tamura, Y & Kumagai, A (1980) Eicosapentaenoic acid and platelet function in Japanese. Lancet i, 1132–1133.CrossRefGoogle Scholar
Katan, MB, van Birgelen, A, Deslypere, JP, Penders, M & van Staveren, WA (1991) Biological markers of dietary intake, with emphasis on fatty acids. Annals of Nutrition and Metabolism 35, 249–252.Google Scholar
Kim, DN, Eastman, A, Baker, JE, Mastrangelo, A, Sethi, S, Ross, JS, Schmee, J & Thomas, WA (1995) Fish oil, atherogenesis and thrombogenesis. Annals of the New York Academy of Sciences 748, 474–481.Google Scholar
Kromhout, D, Bosschieter, EB & de Lezenne Coulander, C (1985) The inverse relation between fish consumption and 20-year mortality from coronary heart disease. New England Journal of Medicine 312, 1205–1209.Google Scholar
Leaf, A & Weber, PC (1988) Cardiovascular effects of n−3 fatty acids. New England Journal of Medicine 318, 549–557.CrossRefGoogle Scholar
Li, X & Steiner, M (1991) Dose response of dietary fish oil supplementations on platelet adhesion. Arteriosclerosis and Thrombosis 11, 39–46.CrossRefGoogle ScholarPubMed
Mantzioris, E, James, MJ, Gibson, RA & Cleland, LG (1995) Differences exist in the relationships between dietary linoleic and α-linolenic acids and their respective long-chain metabolites. American Journal of Clinical Nutrition 61, 320–324.CrossRefGoogle ScholarPubMed
Roche, H & Gibney, MJ (1994) The effect of consumption of fish oil-enriched spreadable fats on platelet phospholipid fatty acid composition in human volunteers. International Journal of Vitamin and Nutrition Research 64, 237–242.Google Scholar
Roche, HM & Gibney, MJ (1996) Postprandial triacylglycerolaemia: the effect of low-fat dietary treatment with and without fish oil supplementation. European Journal of Clinical Nutrition 50, 617–624.Google ScholarPubMed
Sanders, TAB, Hinds, A & Pereira, C (1989) Influence of n−3 fatty acids on blood lipids in normal subjects. Journal of Internal Medicine 225, 99–104.CrossRefGoogle Scholar
Sanders, TAB, Vickers, M & Haines, AP (1981) Effect on blood lipids and haemostasis of a supplement of cod-liver oil, rich in eicosapentaenoic and docosahexaenoic acids, in healthy young men. Clinical Science 61, 317–324.Google Scholar
Sanders, TAB & Younger, KM (1981) The effect of dietary supplements of ω3 polyunsaturated fatty acids on the fatty acid composition of platelets and plasma choline phosphoglycerides. British Journal of Nutrition 45, 613–616.CrossRefGoogle Scholar
Schmidt, EB, Varming, K, Ernst, E, Madsen, P & Dyerberg, J (1990) Dose-response studies on the effect of n−3 polyunsaturated fatty acids on lipids and haemostasis. Thrombosis Haemostasis 63, 1–5.Google ScholarPubMed
Scientific Committee for Food (1993) Essential fatty acids. Reports of the Scientific Committee for Food. Series no. 31, Nutrient and Energy Intakes for the European Community, pp. 52–59. Luxembourg: Commission of the European Communities.Google Scholar
Singh, B, Niaz, MA, Sharma, JP, Dumar, R, Rastogi, V & Moshiri, M (1997) Randomized, double-blind, placebo controlled trial of fish oil and mustard oil in patients with suspected acute myocardial infarction: The Indian experiment of infarct survival – 4. Cardiovascular Drugs and Therapy 11, 485–491.CrossRefGoogle ScholarPubMed
Siscovick, DS, Raghunathan, TE, King, I, Weinamn, S, Wicklund, KG, Albright, J, Bovbjerg, V, Arbogast, P, Smith, H, Kushi, LH, Cobb, LA, Copass, MK, Psaty, BM, Lemaitre, R, Retzlaff, B, Childs, M & Knopp, RH (1995) Dietary intake and cell membrane levels of long-chain n−3 polyunsaturated fatty acids and the risk of primary cardiac arrest. Journal of the American Medical Association 274, 1363–1367.CrossRefGoogle ScholarPubMed
Wallace, JM, Turley, E, Gilmore, WS & Strain, JJ (1995) Dietary fish oil supplementation alters leukocyte function and cytokine production in healthy women. Arteriosclerosis, Thrombosis and Vascular Biology 15, 185–189.Google Scholar